Patents by Inventor Stefan Haefner

Stefan Haefner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090004705
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: February 13, 2008
    Publication date: January 1, 2009
    Applicant: BASF Aktiengesellschaft
    Inventors: Burkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwing Schroder, Stefan Haefner
  • Publication number: 20080286841
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: February 27, 2008
    Publication date: November 20, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Burkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner
  • Publication number: 20080274516
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: December 16, 2004
    Publication date: November 6, 2008
    Inventors: Burkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner
  • Publication number: 20080268502
    Abstract: The present invention relates to multiple promoters and to expression units comprising them; to the use thereof for regulating transcription and expression of genes; to expression cassettes which comprise multiple promoters or expression units of this kind; to vectors which comprise such expression cassettes; to genetically modified microorganisms which comprise vectors and/or expression units of this kind; and to processes for preparing biosynthetic products by culturing said genetically modified microorganisms.
    Type: Application
    Filed: March 14, 2008
    Publication date: October 30, 2008
    Inventors: Stefan Haefner, Hartwig Schroder, Oskar Zelder, Corinna Klopprogge, Andrea Herold
  • Publication number: 20080176295
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: March 17, 2008
    Publication date: July 24, 2008
    Inventors: Oskar Zelder, Corinna Klopprogge, Burkhard Kroger, Hartwig Schroder, Stefan Haefner
  • Publication number: 20080166775
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: February 27, 2008
    Publication date: July 10, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Burkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner
  • Patent number: 7381549
    Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: June 3, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Burkhard Kröger, Oskar Zelder, Corinna Klopprogge, Hartwig Schröder, Stefan Häfner
  • Publication number: 20080118948
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: December 15, 2004
    Publication date: May 22, 2008
    Applicant: BASF Aktiengesellschaft
    Inventors: Burkhard Kroger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroder, Stefan Haefner
  • Publication number: 20070269871
    Abstract: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.
    Type: Application
    Filed: July 16, 2005
    Publication date: November 22, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Oskar Zelder, Corinna Klopprogge, Burkhard Kroger, Hartwig Schroder, Stefan Haefner
  • Patent number: 7282357
    Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metF) gene.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: October 16, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Burkhard Kröger, Oskar Zelder, Corinna Kolpprogge, Hartwig Schröder, Stefan Häfner
  • Publication number: 20070218526
    Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (meta) gene.
    Type: Application
    Filed: May 8, 2007
    Publication date: September 20, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Burkhard Kroeger, Oskar Zelder, Corinna Klopprogge, Hartwig Schroeder, Stefan Haefner
  • Patent number: 7238502
    Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metA) gene.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: July 3, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Burkhard Kröger, Oskar Zelder, Corinna Kolpprogge, Hartwig Schröder, Stefan Häfner
  • Publication number: 20070122887
    Abstract: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 31, 2007
    Applicant: BASF Aktiengesellschaft
    Inventors: Corinna Klopprogge, Oskar Zelder, Burkhard Kroger, Hartwig Schroder, Stefan Haefner, Uwe Ruffer, Claudia Graef
  • Patent number: 7192749
    Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: March 20, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Corinna Klopprogge, Oskar Zelder, Burkhard Kröger, Hartwig Schröder, Stefan Häfner, Heung-Shick Lee
  • Publication number: 20060223149
    Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.
    Type: Application
    Filed: April 16, 2003
    Publication date: October 5, 2006
    Inventors: Burkhard Kröger, Oskar Zelder, Corinna Klopprogge, Hartwig Schröder, Stefan Häfner
  • Publication number: 20030162267
    Abstract: Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.
    Type: Application
    Filed: November 29, 2002
    Publication date: August 28, 2003
    Inventors: Markus Pompejus, Burkhard Kroger, Hartwig Schroder, Oskar Zelder, Gregor Haberhauer, Stefan Haefner, Corrinna Klopprogge