Patents by Inventor Stefan Hecht
Stefan Hecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240010749Abstract: Antibodies which bind human CEACAM5 protein, as well as isolated nucleic acids and host cells containing a sequence encoding said antibodies are disclosed. Immunoconjugates containing said antibodies linked to a growth-inhibitory agent, and pharmaceutical compositions containing antibodies or said immunoconjugates are also disclosed. A use of the antibodies, immunoconjugates, and pharmaceutical compositions disclosed herein is provided for the treatment of cancer or for diagnostic purposes.Type: ApplicationFiled: August 13, 2021Publication date: January 11, 2024Applicant: Merck Patent GmbHInventors: Jan ANDERL, Sabine RAAB-WESTPHAL, Stefan HECHT, Carl DEUTSCH, Min SHAN, Doreen KÖNNING, Willem N. SLOOT, Felix HART, Christian SCHRÖTER, Lars TOLEIKIS, Nir BERGER
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Publication number: 20230406426Abstract: A track running gear for a track chassis of a civilian tracked vehicle, having a rubber continuous track guided circumferentially over an end drive wheel, an opposite tension wheel and over a plurality of running wheels. Each of the running wheels touches a lower strand of the rubber continuous track. At least two of the running wheels touch an upper strand, which upper strand is located opposite the lower strand, of the rubber continuous track.Type: ApplicationFiled: June 14, 2023Publication date: December 21, 2023Inventors: Alexander FINK, Stefan HECHT, Marius HOLDER
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Patent number: 10634484Abstract: There is provided a fast and a reliable way to inspect a condition of a chain by an arrangement comprising a camera and guide for positioning a chain in front of the camera such that holes of consecutive chain links are visible to the camera. In a method for inspecting a chain connected movable to a hoisting device, the chain is positioned in front of the camera by the guide and the chain is driven past the camera by the hoisting device.Type: GrantFiled: July 5, 2016Date of Patent: April 28, 2020Assignee: KONECRANES GLOBAL CORPORATIONInventors: Jack Hoover, Lasse Eriksson, Teemu Puustinen, Risto Vilppo, Kimmo Rantala, Juhani Kerovuori, Stefan Hecht
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Publication number: 20180195854Abstract: There is provided a fast and a reliable way to inspect a condition of a chain by an arrangement comprising a camera and guide for positioning a chain in front of the camera such that holes of consecutive chain links are visible to the camera. In a method for inspecting a chain connected movable to a hoisting device, the chain is positioned in front of the camera by the guide and the chain is driven past the camera by the hoisting device.Type: ApplicationFiled: July 5, 2016Publication date: July 12, 2018Applicant: KONECRANES GLOBAL CORPORATIONInventors: Jack HOOVER, Lasse ERIKSSON, Teemu PUUSTINEN, Risto VILPPO, Kimmo RANTALA, Juhani KEROVUORI, Stefan HECHT
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Publication number: 20090199313Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for conferring herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: ApplicationFiled: October 26, 2007Publication date: August 6, 2009Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeier, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul
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Patent number: 7534742Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: GrantFiled: September 25, 2006Date of Patent: May 19, 2009Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Lüttgen, Felix Rohdich, Silvia Sagner, Christoph A. Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart H. Zenk
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Publication number: 20080318227Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: ApplicationFiled: August 30, 2007Publication date: December 25, 2008Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Patent number: 7402408Abstract: Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl diphosphate by the following steps: (a) reacting an aqueous mixture containing 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate, a 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphnte reductase, and a reducing agent under predetermined reaction conditions for a predetermined period of time; (b) analyzing the reaction mixture obtained in step (a) for the consumed amount of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate and/or NAD(P)H and/or for the produced amount of isopentenyl diphosphate, and/or dimethylallyl diphosphate and/or NAD(P)+; (c) repeating step (a) in the presence of the sample to be tested; (d) repeating step (b) with the reaction mixture defined in step (c); (e) comparing the results of steps (b) and (d).Type: GrantFiled: January 15, 2004Date of Patent: July 22, 2008Assignee: Adelbert BacherInventors: Adelbert Bacher, Petra Adam, Wolfgang Eisenreich, Tobias Gräwert, Stefan Hecht, Felix Rohdich, Ferdinand Zepeck
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Patent number: 7297509Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: GrantFiled: April 10, 2002Date of Patent: November 20, 2007Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Patent number: 7288367Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: GrantFiled: June 1, 2001Date of Patent: October 30, 2007Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeier, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul
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Publication number: 20070015216Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: ApplicationFiled: September 25, 2006Publication date: January 18, 2007Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Luttgen, Felix Rohdich, Silvia Sagner-Grehn, Christoph Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart Zenk
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Patent number: 7122331Abstract: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibiors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.Type: GrantFiled: August 3, 2000Date of Patent: October 17, 2006Inventors: Wolfgang Eisenreich, Monika Fellermeier, Markus Fischer, Stefan Hecht, Stefan Herz, Klaus Kis, Holger Lüttgen, Felix Rohdich, Silvia Sagner-Grehn, Christoph A. Schuhr, Jurathip Wungsintaweekul, Adelbert Bacher, Meinhart H. Zenk
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Publication number: 20060099668Abstract: Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl diphosphate by the following steps: a) reacting an aqueous mixture containing 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate, a 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate reductase, and a reducing agent under predetermined reaction conditions for a predetermined period of time; b) analyzing the reaction mixture obtained in step (a) for the consumed amount of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate and/or NAD(P)H and/or for the produced amount of isopentenyl diphosphate, and/or dimethylallyl diphosphate and/or NAD(P)+; c) repeating step (a) in the presence of the sample to be tested; d) repeating step (b) with the reaction mixture defined in step (c); e) comparing the results of steps (b) and (d).Type: ApplicationFiled: January 15, 2004Publication date: May 11, 2006Applicant: Adelbert BacherInventors: Adelbert Bacher, Petra Adam, Wolfgang Eisenreich, Tobias Grawert, Stefan Hecht, Felix Rohdich, Ferdinand Zepeck
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Publication number: 20040226502Abstract: This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.Type: ApplicationFiled: June 14, 2004Publication date: November 18, 2004Inventors: Adelbert Bacher, Stefan Hecht, Robert Huber, Johannes Kaiser, Felix Rohdich, Stefan Steinbacher
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Publication number: 20040176570Abstract: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.Type: ApplicationFiled: April 7, 2004Publication date: September 9, 2004Inventors: Adelbert Bacher, Felix Rohdich, Petra Adam, Sabine Amslinger, Wolfgang Eisenreich, Stefan Hecht
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Publication number: 20040072142Abstract: The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.Type: ApplicationFiled: July 8, 2003Publication date: April 15, 2004Inventors: Adelbert Bacher, Meinhart H. Zenk, Petra Adam, Wolfgang Eisenreich, Monika Fellermeir, Stefan Hecht, Felix Rohdich, Christoph A. Schuhr, Juraithip Wungsintaweekul