Patents by Inventor Stefan Herlitze

Stefan Herlitze has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN ROD-CONE DYSTROPHY (RCD)
    Publication number: 20230338581
    Abstract: The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones for use in the treatment of patients with RCD.
    Type: Application
    Filed: October 11, 2022
    Publication date: October 26, 2023
    Inventors: Deniz DALKARA, Cardillia-Joe SIMON, Stefan HERLITZE, José-Alain SAHEL, Isabelle AUDO, Serge PICAUD, Stéphane Bertin
  • G-PROTEIN-GATED-K+ CHANNEL-MEDIATED ENHANCEMENTS IN LIGHT SENSITIVITY IN ROD-CONE DYSTROPHY (RCD)
    Publication number: 20230159609
    Abstract: The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones.
    Type: Application
    Filed: July 10, 2020
    Publication date: May 25, 2023
    Inventors: Deniz DALKARA, Cardillia-Joe SIMON, Stefan HERLITZE, José-Alain SAHEL, Isabelle AUDO, Serge PICAUD, Stéphane Bertin
  • System and method for controlling G-protein coupled receptor pathways
    Patent number: 10227391
    Abstract: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular cone opsin or melanopsin domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: March 12, 2019
    Assignee: Case Western Reserve University
    Inventors: Stefan Herlitze, Lynn Landmesser
  • SYSTEM AND METHOD FOR CONTROLLING G-PROTEIN COUPLED RECEPTOR PATHWAYS
    Publication number: 20160333069
    Abstract: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular cone opsin or melanopsin domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway.
    Type: Application
    Filed: March 14, 2016
    Publication date: November 17, 2016
    Inventors: Stefan Herlitze, Lynn Landmesser
  • System and method for controlling G-protein coupled receptor pathways
    Patent number: 9284363
    Abstract: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a heterologous intracellular domain capable of modulating an intracellular signaling pathway.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: March 15, 2016
    Assignee: Case Western Reserve University
    Inventors: Stefan Herlitze, Lynn Landmesser
  • COMPOSITIONS AND METHODS FOR TREATING A NEURONAL INJURY OR NEURONAL DISORDERS
    Publication number: 20110112463
    Abstract: A method of improving the efficacy of denervated, quiescent, or dormant motor neurons includes expressing light sensitive G protein coupled receptors in the motor neurons, the light sensitive G protein coupled receptors modulating cellular activity in the motor neurons upon exposure to a wavelength of light and exposing the motor neurons expressing the light sensitive G protein coupled receptors to the wavelength of light.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 12, 2011
    Inventors: JERRY SILVER, Stefan Herlitze, Warren Alilain
  • LIGHT-SENSITIVE CONSTRUCTS FOR INDUCING CELL DEATH AND CELL SIGNALING
    Publication number: 20100021982
    Abstract: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a hetorologous intracellular domain capable of modulating an intracellular signaling pathway.
    Type: Application
    Filed: December 6, 2007
    Publication date: January 28, 2010
    Inventor: Stefan Herlitze
  • SYSTEM AND METHOD FOR CONTROLLING G-PROTEIN COUPLED RECEPTOR PATHWAYS
    Publication number: 20100009444
    Abstract: A light-sensitive G-protein coupled receptor includes a light sensitive extracellular domain and a heterologous intracellular domain capable of modulating an intracellular signaling pathway.
    Type: Application
    Filed: July 26, 2007
    Publication date: January 14, 2010
    Inventors: Stefan Herlitze, Lynn Landmesser