Patents by Inventor Stefan Hildrand

Stefan Hildrand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030105335
    Abstract: The invention relates to &bgr;-alaninamides of general formula (I), wherein: R1 represents hydrogen or C1-C6 alkyl which is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, or by optionally substituted aryl or heteroaryl; R2 represents hydrogen or R1 and R2, together, form a group of formula —(CH2)n, wherein n represents 3 or 4, and; R3 represents hydrogen, a negative charge compensated for by an equivalent of an inorganic or organic cation or represents C1-C6 alkyl. The &bgr;-alaninamides are produced without using an amino protective group by reacting the corresponding &agr;-amino acid or the corresponding &agr;-amino acid ester with a cyanoacetic acid to form a cyanoacetic acid amide and by a subsequent catalytic hydrogenation. The method is particularly suited for producing carnosine (&bgr;alanyl-L-histidine, R1=imidazol-4-yl-methyl, R2═R3═H), a naturally occurring dipeptide, which is used as a food additive having an antioxidant effect.
    Type: Application
    Filed: November 21, 2002
    Publication date: June 5, 2003
    Inventors: Stefan Hildrand, Thomas Ruppen, Dario Veghini