Abstract: The present invention relates to certain intermediates useful in the preparation of certain benzoimidazol-2-yl pyrimidines and processes for preparing them.

Abstract: The present invention relates to certain intermediates useful in the preparation of certain benzoimidazol-2-yl pyrimidines and processes for preparing them.

Abstract: The invention relates to a device for producing a cold atmospheric pressure plasma for the treatment of human and/or animal surfaces, comprising a flexible, planar multilayer system with a side facing the surface to be treated and a side facing away from the surface to be treated, wherein the multilayer system comprises the following layers, namely a first electrode layer on the facing away side of the multilayer system, second electrode layer on the facing side of the multilayer system, wherein the electrode layer has a plurality of recesses or is formed in a grid-like or meander-shaped fashion, a dielectric layer arranged between the first electrode layer and the second electrode layer, and a spacer layer arranged adjacent the second electrode layer on the facing side of the multilayer system. In addition, the invention relates to a cable, a generator unit for providing a high voltage, and a system.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: A device for generating plasma (1) comprises a high voltage electrode (10) as well as at least one external electrode (11, 12), wherein the high voltage electrode (10) at least in one coordinate direction (34) is arranged between conductive material of at least one external electrode (11, 12). The high voltage electrode (10) is covered with a dielectric (21) at least one side facing an external electrode (11, 12). Between the respective external electrode (11, 12) and the high voltage electrode (10) over its longitudinal extension at least one spacer element (20) is present, which at least in the region of its arrangement electrically insulates the respective external electrode (11,12) from the high voltage electrode (10) and which positions the respective external electrode (11, 12) at a constant distance from the high voltage electrode (10), wherein the spacer element is a gas-permeable foil.

Abstract: The present invention relates to certain intermediates useful in the preparation of certain benzoimidazol-2-yl pyrimidines and processes for preparing them.

Abstract: Computer system configured to generate an engineering work-flow, said system comprising a first database which stores a library of engineering patterns and a second database which stores a library of engineering tool functions of an engineering tool, wherein a sequence of automatically concatenated workflow steps forming said engineering workflow is generated by mapping for each workflow step a selected engineering pattern to a selected tool function of said engineering tool.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: The invention relates to a device, preferably a collar, for treating areas of human or animal skin or mucous membrane with a cold atmospheric pressure plasma by creating a dielectrically hindered surface discharge, comprising at least one flexible insulating material (1), a flexible high-voltage electrode (2), a flexible dielectric (3), a flexible grounded electrode (4) and a gas supply (7), characterized in that the flexible high-voltage electrode (2) is embedded in the insulating elastomer (3), having the effect of a dielectric, and the grounded electrode (4) is applied to the elastomer surface facing the surface to be treated.

Abstract: A temperature-control station of a thermoforming assembly for hot forming and press hardening a metallic structure includes a heat source in the form of at least one flat inductor which is provided on a lower tool and/or upper tool. A temperature-control plate is placed upon the inductor for support of the structure. The temperature-control plate is configured to accommodate at least one cooling channel for passage of a gaseous coolant so that two zones of the structure are adjustable to temperatures that are different from one another.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: The present invention is directed to an improved process for the preparation of sulfamide derivatives.

Abstract: Computer system configured to generate an engineering workflow, said system comprising a first database which stores a library of engineering patterns and a second database which stores a library of engineering tool functions of an engineering tool, wherein a sequence of automatically concatenated workflow steps forming said engineering workflow is generated by mapping for each workflow step a selected engineering pattern to a selected tool function of said engineering tool.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

Abstract: Within methods and systems for computer-aided optimization of process models, defined specifications and associated release criteria (quality gates) are available for every work stage. The specifications include service documents, result features that are to be generated in a work stage, and budget details and the latest end time for a work stage. The release criteria (quality gates) can identify the results of a work stage as successful and can assess the fulfillment of a work stage. A reference for all work stages simulates the model based on a fictitious sample project, interference variables are introduced, the project implementation is simulated for each interference variable, respectively, the deviations from the reference run are automatically determined, respectively, for each interference variable, and an analysis of the influence of the release criteria (quality gates) regarding compliance with the budget and the schedule is performed based on the determined deviations from the reference run.

Abstract: The invention relates to a special plasma source designated as a plasma intractor (PI) for producing a cold, homogeneous plasma under atmospheric pressure conditions, which plasma source can be used advantageously to excite and control reactive processes in flowing media. The device according to the invention is characterized in that the device comprises at least 6 elongated electrodes (2) and a molded body (1) made of insulating material, the molded body (1) being provided with an elongated cylindrical cavity (7) and with additional holes, which are guided parallel to the cavity (7) and arranged symmetrical to the axis of the cavity and equidistant to one another, and the electrodes (2) are embedded in holes of the molded body (1) and are connected to an AC high-voltage supply in such a way that the polarities of respective adjacent electrodes are opposite in each phase of the voltage period.