Patents by Inventor Stefan Horvath

Stefan Horvath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200347461
    Abstract: Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that composite clinical measures of “phenotypic age”, may facilitate the development of a more powerful epigenetic biomarker of aging. Here we show that our newly developed epigenetic biomarker of aging “DNAm PhenoAge” strongly outperforms previous measure in regards to predictions for a variety of aging outcomes, including all-cause mortality, cancers, physical functioning, and, age-related dementia. It is also associated with Down syndrome, HIV infection, socioeconomic status, and various life style factors such as diet, exercise, and smoking. Overall, this single epigenetic biomarker of aging is able to capture risks for an array of diverse outcomes across multiple tissues and cells, and in moving forward, will facilitate the development of anti-aging interventions.
    Type: Application
    Filed: January 17, 2019
    Publication date: November 5, 2020
    Applicants: The Regents of the University of California, National Institutes of Health
    Inventors: Stefan Horvath, Morgan E. Levine, Luigi Ferrucci
  • Publication number: 20200031329
    Abstract: A method for operating a brake system of a vehicle in a maintenance mode and in a normal mode includes providing a brake pressure in the brake system in the normal mode using a brake pressure generator. The method further includes preventing a provision of a brake pressure by the brake pressure generator in the maintenance mode.
    Type: Application
    Filed: July 30, 2019
    Publication date: January 30, 2020
    Inventors: Christian Michael Praetorius, Verena Friedrich, Alexander Horvath, Markus Hoffmann, Markus Bartel, Nikolai Mueller, Stefan Bachmayer, Stefan Zahariev
  • Publication number: 20190185938
    Abstract: A method for determining the epigenetic age acceleration of an individual comprising measuring a methylation level of a set of methylation markers in genomic DNA of an individual. An epigenetic age of the individual is determined based on the measured methylation level. An epigenetic age of the individual is further determined based on a methylation derived weighted average cell count of naive cytotoxic T cells and exhausted cytotoxic T cells in the individual. The determined epigenetic age is then compared to a chronological age of the individual to determine an epigenetic age acceleration of the individual. Instances wherein the epigenetic age is greater than the chronological age of the individual is an indication of an increased risk of all-cause mortality.
    Type: Application
    Filed: August 7, 2017
    Publication date: June 20, 2019
    Inventor: Stefan Horvath
  • Publication number: 20170333450
    Abstract: The present invention provides methods comprising treating and/or preventing cognitive dysfunction in subjects infected with HIV by administering an antioxidant inflammation modulator (AIM). The present invention also provides for methods for treating and/or preventing an HIV-associated neurocognitive disorder by contacting peripheral blood monocytes of an HIV+subject with an AIM.
    Type: Application
    Filed: October 30, 2015
    Publication date: November 23, 2017
    Inventors: Andrew Levine, Dimitrios Vatakis, Stefan Horvath, Dennis L. Kolson
  • Publication number: 20160222448
    Abstract: A method for determining the age of a biological sample comprising measuring a methylation level of a set of methylation markers in genomic DNA of the biological sample. An age of the biological sample is determined with a statistical prediction algorithm, comprising (a) obtaining a linear combination of the methylation marker levels, and (b) applying a transformation to the linear combination to determine the age of the biological sample.
    Type: Application
    Filed: September 29, 2014
    Publication date: August 4, 2016
    Applicant: The Regents of the University of California
    Inventor: Stefan Horvath
  • Patent number: 5484265
    Abstract: An excess temperature and starting safety device for a magnetic centrifugal pump, having a rotor which delivers the medium and whose shaft terminates at a gap dish, where it bears permanent magnets driven by oppositely disposed permanent magnets which are connected to the shaft of the driving motor, while attached to the inner or outer surface of the gap dish is a conductor, more particularly a piece of wire of a thermocouple whose other conductor, closing the conductor circuit, is formed by the gap dish.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: January 16, 1996
    Assignee: Junkalor GmbH Dessau
    Inventors: Stefan Horvath, Karl Schmidt, Henry Schommer, Gerhard Fiedler