Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A simple, compact, and economical motor/pump unit for supplying vacuum to a pneumatic brake booster of a motor-vehicle brake system, wherein the motor/pump unit is designed as a diaphragm pump having a single elastomeric diaphragm, which is moved by an electrically operated motor unit by an eccentric drive, and has a pump housing and a working-space cover and the diaphragm is clamped between the pump housing and the working-space cover at the radial outer edge of the diaphragm in a sealing manner and the working-space cover is designed as a multi-part working-space cover having an upper cover, a lower cover, and an inlet valve and an outlet valve, which are arranged between the upper cover and the lower cover and control the air circulation through the working space.

Abstract: A simple, compact, and economical motor/pump unit for supplying vacuum to a pneumatic brake booster of a motor-vehicle brake system, wherein the motor/pump unit is designed as a diaphragm pump having a single elastomeric diaphragm, which is moved by an electrically operated motor unit by an eccentric drive, and has a pump housing and a working-space cover and the diaphragm is clamped between the pump housing and the working-space cover at the radial outer edge of the diaphragm in a sealing manner and the working-space cover is designed as a multi-part working-space cover having an upper cover, a lower cover, and an inlet valve and an outlet valve, which are arranged between the upper cover and the lower cover and control the air circulation through the working space.

Abstract: The invention relates to a pump unit that can be driven by an electric motor, in particular for providing vacuum for a pneumatic brake booster, including a pump housing that can be closed by a working-chamber cover and at least one elastic displacement element, wherein a working chamber is bounded between the displacement element and the working-chamber cover and wherein inlet valves and outlet valves and inlet channels and outlet channels associated with the valves are associated with the working chamber. According to the invention, in order to reduce noise emissions, devices for reducing a contact surface between the working-chamber cover and the pump housing are provided.

Abstract: A pump assembly for supplying negative pressure to a pneumatic brake booster, wherein the pump assembly has at least two elastic displacement elements which are moved by connecting rods, the connecting rods each being rotatably mounted on an eccentric element. The eccentric element has a bearing seat element and a force element. At least two eccentric elements are secured next to each other on a drive shaft that rotates about an axis of rotation and an interlocking anti-rotation device is provided that determines a defined angular position of the eccentric elements relative to each other about the axis of rotation. In order to improve the ease of assembly and simplify the manufacturability, the anti-rotation device is designed as shaped elements of the bearing seat element in such a way that they engage in each other in an interlocking manner when the eccentric elements are in a defined angular position relative to each other.

Abstract: A pump assembly for supplying negative pressure to a pneumatic brake booster, wherein the pump assembly has at least two elastic displacement elements which are moved by connecting rods, the connecting rods each being rotatably mounted on an eccentric element. The eccentric element has a bearing seat element and a force element. At least two eccentric elements are secured next to each other on a drive shaft that rotates about an axis of rotation and an interlocking anti-rotation device is provided that determines a defined angular position of the eccentric elements relative to each other about the axis of rotation. In order to improve the ease of assembly and simplify the manufacturability, the anti-rotation device is designed as shaped elements of the bearing seat element in such a way that they engage in each other in an interlocking manner when the eccentric elements are in a defined angular position relative to each other.

Abstract: The invention relates to a pump unit that can be driven by an electric motor, in particular for providing vacuum for a pneumatic brake booster, including a pump housing that can be closed by a working-chamber cover and at least one elastic displacement element, wherein a working chamber is bounded between the displacement element and the working-chamber cover and wherein inlet valves and outlet valves and inlet channels and outlet channels associated with the valves are associated with the working chamber. According to the invention, in order to reduce noise emissions, devices for reducing a contact surface between the working-chamber cover and the pump housing are provided.

Abstract: A valve for the control of a gas stream is provided with a valve housing enclosing a valve chamber. At least one pressure-sided inlet and at least one suction-sided outlet is provided with a valve opening between them to link them. An elastically movable control membrane is arranged at the valve housing which reduces or increases the flow cross section in the area of the at least one valve opening and/or opens or closes the at least one valve opening. A first device exerts a first further force on the control membrane in such a way that with an increasing pressure difference the further force exerted by the first device on the control membrane in opposite direction to the closure direction of the valve increases.

Abstract: A valve for the control of a gas stream is provided with a valve housing enclosing a valve chamber. At least one pressure-sided inlet and at least one suction-sided outlet is provided with a valve opening between them to link them. An elastically movable control membrane is arranged at the valve housing which reduces or increases the flow cross section in the area of the at least one valve opening and/or opens or closes the at least one valve opening. A first device exerts a first further force on the control membrane in such a way that with an increasing pressure difference the further force exerted by the first device on the control membrane in opposite direction to the closure direction of the valve increases.