Abstract: Systems and methods are disclosed for managing task assignments for a fleet of haul trucks at a mine site. An assignment engine may: receive state data for a haul truck including haul weight data and second state data for the mine site that is indicative of a plurality of available tasks and associated task material weight data; assign a task to the haul truck by inputting the state data into a trained reinforcement-learning model, wherein: the model has been trained to learn an assignment policy that optimizes a reward function, such that the learned policy accounts for vehicle performance variance due to changing vehicle haul weight and/or road conditions; and cause the at least one haul truck to be operated according to the at least one task assignment.

Abstract: A mine site electrification planning apparatus includes a model component to simulate mine site operations under a mine site electrification plan. A simulation control component may provide configuration data to the model component that are descriptive of varying distributions of zero greenhouse gas emitting (ZGHG) mining assets for which the mine site electrification plan is simulated. An optimization control component may identify the configuration data associated with the simulated mine site electrification plan that meets an economic optimization criterion related to physically implementing the mine site electrification plan.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

Abstract: The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

Abstract: Systems and methods are disclosed for managing task assignments for a fleet of haul trucks at a mine site. An assignment engine may: receive state data for a haul truck including haul weight data and second state data for the mine site that is indicative of a plurality of available tasks and associated task material weight data; assign a task to the haul truck by inputting the state data into a trained reinforcement-learning model, wherein: the model has been trained to learn an assignment policy that optimizes a reward function, such that the learned policy accounts for vehicle performance variance due to changing vehicle haul weight and/or road conditions; and cause the at least one haul truck to be operated according to the at least one task assignment.

Abstract: The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.

Abstract: The present invention provides to a method for the introducing polynucleotide molecules into fungal spores comprising exposing a mixture of fungal spores and magnetic nanoparticles carrying the polynucleotide to a magnet and/or a magnetic field. The present invention also provides a method for transformation a fungus comprising the steps of the method steps disclosed herein and allowing the integration of said polynucleotide molecules into the genome of said spores, thereby transforming the spore. The present invention also provides a system for delivery of nucleic acids to fungal spores comprising magnetic nanoparticles loaded with nucleic acids, a kit for transformation of fungal spores with a polynucleotide comprising MNPs loaded with the polynucleotide and fungal spores as well as a composition comprising MNPs loaded with nucleic acid molecules and fungal spores.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

Abstract: A charging device for an internal combustion engine with rotor cooling has a shaft, a compressor wheel mounted on the shaft, a stator housing and a stator. The stator is arranged in the stator housing. The charging device additionally has a rotor arranged rotatably fixed on the shaft The rotor is surrounded by the stator. A first fan device is arranged for common rotation with the shaft in order to generate a circulating air flow in the stator housing for cooling the rotor.

Abstract: The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.

Abstract: An apparatus (mulcher) for keeping down groundcover between parallel rows of plants, especially rows of wine grape or fruit plants, with two chopping blade rotors rotating in one and the same plane, each around an axis perpendicular to the ground. The distance between the rotational axes is adjustable in a direction perpendicular to the plant rows even though the rotational areas of the chopping blade rotors may overlap. A separate electric motor is assigned to each of the chopping blade rotors, and devices are provided to control the electric motor so that that collisions between the chopping blade rotors are avoided.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: A method for detecting an unbalanced payload condition in a machine is disclosed. The method includes detecting, by a first sensor, a pressure exerted on each of one or more struts in the machine by a payload. The method further includes detecting, by a second sensor, one or more operational parameters associated with machine. Furthermore, method includes determining, by a controller, a center of gravity of the payload based on detected pressure, the one or more operational parameters, and one or more dimensions of the machine. Additionally, the method includes determining, by the controller, a force being exerted, by the payload, on each traction member of the machine based on the center of gravity of the payload. The method further includes detecting, by the controller, the unbalanced payload condition when the force, being exerted on at least one traction member of the plurality of traction members, exceeds a threshold value.

Abstract: The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.

Abstract: A charging device for an internal combustion engine with rotor cooling has a shaft, a compressor wheel mounted on the shaft, a stator housing and a stator. The stator is arranged in the stator housing. The charging device additionally has a rotor arranged rotatably fixed on the shaft The rotor is surrounded by the stator. A first fan device is arranged for common rotation with the shaft in order to generate a circulating air flow in the stator housing for cooling the rotor.