Abstract: The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.

Abstract: A method for modifying an existing single shaft combined cycle power plant having a steam turbine part and a gas turbine part which are connected to each other rigidly by an intermediate shaft. The gas turbine part is supported by two pin-ended supports allowing a certain axial displacement of the casing by rotating about corresponding axes. The old gas turbine part is replaced by a new gas turbine part having a different structure, namely a rigid support and a flexible support. Relative thermal expansion or displacement of the intermediate shaft is compensated by a hydraulic unit comprising a double-acting piston for displacing the gas turbine rotor with respect to the gas turbine stator. The hydraulic unit is controlled based on a displacement measurement in the steam turbine.

Abstract: The present invention relates to diagnosis and/or prognosis of cardiovascular disease and cardiovascular events. A prognostic risk score in relation to the cardiovascular events, more particular after intervention, can be determined by counting the number of deregulated genes (or derived proteins) in their isolated monocytes. Deregulation means low expression of COX1 and/or COX4I1, and/or TFAM, and/or RUNX2.

Abstract: A method for controlling an SCR system having two metering valves and a feed pump, wherein the two metering valves are operated in such a way that a reducing agent solution is metered in simultaneously via the two metering valves, at least over part of a metering time period (tDos).

Abstract: A method for controlling an SCR system having two metering valves and a feed pump, wherein the two metering valves are operated in such a way that a reducing agent solution is metered in simultaneously via the two metering valves, at least over part of a metering time period (tDos).

Abstract: The present invention relates to treating and/or preventing heart failure or one or more individual heart failure phenotypes in mammals using placental growth factor 2 (PlGF-2).

Abstract: The present invention relates to diagnosis and/or prognosis of cardiovascular disease and cardiovascular events. A prognostic risk score in relation to the cardiovascular events, more particular after intervention, can be determined by counting the number of deregulated genes (or derived proteins) in their isolated monocytes. Deregulation means low expression of COX1 and/or COX4I1, and/or TFAM, and/or RUNX2.

Abstract: A method for operating a rotary machine with a rotor that is mounted in a bearing is provided. The rotor is subjected to a thrust that acts substantially in only an axial direction during the operating time. The thrust is received and dissipated by a first thrust bearing of the bearing via sliding means, the bearing having a second thrust bearing. The axial vibrations of the rotor are damped or completely prevented by means of the second thrust bearing generating a force that acts on the first thrust bearing in the direction of the thrust at least temporarily at the same time as the thrust occurs.

Abstract: The present invention relates to treating and/or preventing heart failure or one or more individual heart failure phenotypes in mammals using placental growth factor 2 (PlGF-2).

Abstract: A method for operating a rotary machine with a rotor that is mounted in a bearing is provided. The rotor is subjected to a thrust that acts substantially in only an axial direction during the operating time. The thrust is received and dissipated by a first thrust bearing of the bearing via sliding means, the bearing having a second thrust bearing. The axial vibrations of the rotor are damped or completely prevented by means of the second thrust bearing generating a force that acts on the first thrust bearing in the direction of the thrust at least temporarily at the same time as the thrust occurs.

Abstract: An alloy is provided. The alloy comprises (in % by weight): silicon 2.0%-4.5%, in particular 2.3%-3.9%, carbon 2.9%-4.0%, in particular 3.2%-3.7%, niobium 0.05%-0.7%, in particular 0.05%-0.6%, molybdenum 0.3%-1.5%, in particular 0.4%-1.0%, and optionally cobalt 0.1%-2.0%, in particular 0.1%-1.0%, manganese ?0.3%, in particular 0.15-0.30%, nickel ?0.5%, in particular ?0.3%, magnesium ?0.07%, in particular at least 0.03%, phosphorus ?0.05%, in particular 0.02%-0.035%, sulfur ?0.012%, in particular ?0.005%, chromium ?0.1%, in particular ?0.05%, antimony ?0.004%, in particular ?0.003%, and iron.

Abstract: Known cast iron alloys have use limits in respect of the temperature. An alloy (in a weight percentage) including silicon 2.0%-4.5%, carbon 2.9%-4.0%, niobium 0.05%-0.7%, molybdenum 0.3%-1.5%, optionally cobalt 0.1%-2.0%, manganese?0.3%, nickel?0.5%, magnesium?0.07%, phosphorus?0.05%, sulphur?0.012%, chromium?0.1%, antimony?0.004%, and, iron, is provided.

Abstract: Known cast iron alloys have application limits with regard to temperature. A cast iron including cobalt is provided. Through the use of cobalt, an optimal ferritic microstructure is achieved such that with an alloy having silicon 2.0-4.5 wt %, cobalt 0.5-5 wt %, carbon 2.0-4 wt %, molybdenum 0.3-1.48 wt %, manganese ?0.5 wt %, nickel ?0.5 wt %, the remainder iron, wherein the proportion of silicon, cobalt, and molybdenum is preferably less than 7.5 wt %, the application limits are shifted to high temperatures.

Abstract: Cast iron alloys have application limits with regard to temperature. By means of the use of cobalt an optimal ferritic structure can be achieved such that with an alloy containing silicon 2.0-4.5 wt. %, cobalt 0.5-5 wt. %, carbon 2.5-4 wt. %, molybdenum?1 wt. %, manganese?0.25 wt. %, nickel?0.3 wt. %, the remainder iron where the proportion of silicon cobalt and molybdenum is less than 7.5 wt. % the application limits are shifted to higher temperatures.

Abstract: Thick-walled parts made via a casting method often exhibit, in those thick zones, the worst mechanical properties since the solidification speed in the zones is reduced relative to the thin-walled zone and frequently induces the worst mechanical properties. There is described a method incorporating solidification control elements in a melting charge, the elements increase locally the solidification speed of the melting charge.

Abstract: Thick-walled parts made by means of a casting method often exhibit, in those thick zones, the worst mechanical properties since the solidification speed in said zones is reduced relative to the thin-walled zone and frequently induces the worst mechanical properties. There is described a method incorporating control elements in a melting charge, said elements increase locally the solidification speed of the melting charge.

Abstract: This invention relates to a gene therapy method for inducing pulmonary vasodilation. More specifically, this invention involves introducing the nitric oxide synthase gene into lungs resulting in pulmonary vasodilation. This results in a hypotensive effect in the pulmonary circulation which does not significantly affect systemic blood pressure or cardiac index. This method is useful to treat primary pulmonary hypertension or pulmonary hypertension secondary to various disease states.

Abstract: This invention relates to a gene therapy method for inducing pulmonary vasodilation. More specifically, this invention involves introducing the nitric oxide synthase gene into lungs resulting in pulmonary vasodilation. This results in a hypotensive effect in the pulmonary circulation which does not significantly affect systemic blood pressure or cardiac index. This method is useful to treat primary pulmonary hypertension or pulmonary hypertension secondary to various disease states.

Abstract: A programmable processing engine and a method of operating the same is described, the processing engine including a customized processor, a flexible processor and a data store commonly sharable between the two processors. The customized processor normally executes a sequence of a plurality of pre-customized routines, usually for which it has been optimized. To provide some flexibility for design changes and optimizations, a controller for monitoring the customized processor during execution of routines is provided to select one of a set of pre-customized processing interruption points and for switching context from the customized processor to the flexible processor at the interruption point. The customized processor can then be switched off and the flexible processor carries out a modified routine. By using sharable a data store, the context switch can be chosen at a time when all relevant data is in the sharable data store. This means that the flexible processor can pick up the modified processing cleanly.

Abstract: A battery-powered computing system (20) including video decoding capability, particularly as pertinent to the H.263 standard, is disclosed. The system (20) includes a main integrated circuit (30) having an on-chip central processing unit (CPU) (32) and on-chip shared memory (33) for the temporary buffering of video image data that is retrieved and generated during the video decoding process. The CPU (32) is programmed to perform a combined P and B prediction process (46) upon a previously predicted P frame (P.sub.T-1), with accesses to internal buffers in shared memory (33) instead of to main memory (40). Preferably, inverse transform processes (48, 52) also access shared memory (33) rather than main memory (40). The combined P and B prediction process (46) preferably handles unrestricted motion vectors using edge pixels (P.sub.