Patents by Inventor Stefan JUST

Stefan JUST has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE-IMIDAZOPYRIDINE DERIVATIVES
    Publication number: 20260199325
    Abstract: The present invention relates to compounds of formula(I), a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, Xa, Xb, Xc, Xd, A, R1 and R6 have meanings given in the description.
    Type: Application
    Filed: December 8, 2023
    Publication date: July 16, 2026
    Inventors: Roland PFAU, Georg DAHMANN, Kai GERLACH, Riccardo GIOVANNINI, Johann Faustus DU HOFFMANN, Christoph HOHN, Stefan JUST, Heiko SOMMER, Christian SPECKER
  • Dioxane derivatives
    Patent number: 12655136
    Abstract: The present invention relates to substituted dioxane derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of neuronal and non-neuronal conditions having an association with mGluR4 function and/or in the treatment of obesity by means of mGluR4 modulation.
    Type: Grant
    Filed: October 27, 2023
    Date of Patent: June 16, 2026
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Georg Dahmann, Johann Faustus Du Hoffmann, Kai Gerlach, Riccardo Giovannini, Christoph Hohn, Stefan Just, Thorsten Lehmann, Anton Pekcec, Julia Schlichtiger, Heiko Sommer, Christian Specker
  • GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS FOR USE IN THE TREATMENT OF SUBSTANCE USE DISORDER IN PATIENTS WITH HIGH IMPULSIVITY
    Publication number: 20260083736
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and n are defined herein, which are ghrelin O-acyl transferase (GOAT) inhibitors. The invention also relates to the use of compounds of formula (I) for treatment of substance use disorder (SUD,) in particular for use in the treatment of opioid use disorder (OUD) or stimulant use disorder (StimUD), in patients with high impulsivity.
    Type: Application
    Filed: September 22, 2025
    Publication date: March 26, 2026
    Inventors: Stefan JUST, Hugo CRUCES SOLIS, Johann Faustus DU HOFFMANN, Jennifer Buenzle DWYER, Janet Rachel NICHOLSON, Katrin Hildegund PRELLER
  • Substituted pyrazine-carboxamide derivatives
    Patent number: 12421218
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Grant
    Filed: August 14, 2024
    Date of Patent: September 23, 2025
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Georg Dahmann, Johann Faustus Du Hoffmann, Kai Gerlach, Riccardo Giovaninni, Christoph Hohn, Stefan Just, Thorsten Lehmann, Anton Pekcec, Stefan Peters, Julia Schlichtiger, Heiko Sommer, Christian Specker, Dieter Wiedenmayer
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240417394
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: August 14, 2024
    Publication date: December 19, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240182453
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: October 27, 2023
    Publication date: June 6, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • NOVEL DIOXANE DERIVATIVES
    Publication number: 20240174652
    Abstract: The present invention relates to substituted dioxane derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of neuronal and non-neuronal conditions having an association with mGluR4 function and/or in the treatment of obesity by means of mGluR4 modulation.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 30, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANNINI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER
  • Somatostatin receptor subtype 4 (SSTR4) agonists
    Patent number: 10675268
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: June 9, 2020
    Assignee: Centrexion Therapeutics Corporation
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • NEW SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
    Publication number: 20190269650
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Application
    Filed: November 2, 2018
    Publication date: September 5, 2019
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • Substituted xanthine derivatives
    Patent number: 10329292
    Abstract: The present invention relates to substituted xanthine derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion channels.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: June 25, 2019
    Assignees: Boehringer Ingelheim International GmbH, Hydra Biosciences, Inc.
    Inventors: Kai Gerlach, Christian Eickmeier, Achim Sauer, Stefan Just, Bertrand L. Chenard
  • NOVEL SUBSTITUTED XANTHINE DERIVATIVES
    Publication number: 20190016722
    Abstract: The present invention relates to substituted xanthine derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion channels.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 17, 2019
    Inventors: Kai Gerlach, Christian Eickmeier, Achim Sauer, Stefan Just, Bertrand L. Chenard
  • Somatostatin receptor subtype 4 (SSTR4) agonists
    Patent number: 10166214
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: January 1, 2019
    Assignee: Centrexion Therapeutics Corporation
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
    Publication number: 20180092880
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Application
    Filed: August 24, 2017
    Publication date: April 5, 2018
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • Somatostatin receptor subtype 4 (SSTR4) agonists
    Patent number: 9789082
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: October 17, 2017
    Assignee: Centrexion Therapeutics Corporation
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • NEW SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
    Publication number: 20170014381
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Application
    Filed: May 18, 2016
    Publication date: January 19, 2017
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doobs, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • Somatostatin receptor subtype 4 (SSTR4) agonists
    Patent number: 9371282
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: June 21, 2016
    Assignee: Centrexion Therapeutics Corporation
    Inventors: Riccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
  • New Somatostatin receptor subtype 4 (SSTR4) agonists
    Publication number: 20140343065
    Abstract: 3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
    Type: Application
    Filed: May 12, 2014
    Publication date: November 20, 2014
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Riccardo GIOVANNINI, Yunhai CUI, Henri DOODS, Marco FERRARA, Stefan JUST, Raimund KUELZER, Iain LINGARD, Rocco MAZZAFERRO, Klaus RUDOLF