Abstract: An actuating mechanism for actuating a charging or fueling flap on a charging or fueling compartment received on or in a body component of a vehicle, wherein the charging or fueling flap is reversibly movable between a closed position and an open position, wherein a flap lock is provided for locking the charging or fueling flap in its closed position. The actuating mechanism includes a drive having a drive shaft, which is operatively connectable to the charging or fueling flap such that, upon rotation of the drive shaft, the charging or fueling flap is movable relative to the charging or fueling compartment. The actuating mechanism further includes a mechanical control or switching mechanism, which is configured such that, upon rotation of the drive shaft to manipulate the flap lock, a rotational movement of the drive shaft can be tapped with the aid of the mechanical control or switching mechanism.

Abstract: An electromechanical brake booster for a vehicle brake system is disclosed. The electromechanical brake booster has an actuating element which is couplable to an electric motor via a transmission, a housing in which the actuating element is displaceably received, and at least one sliding element which is arranged between the housing and the actuating element. A vehicle brake system, subassembly therefor and sliding element is also disclosed.

Abstract: An actuating mechanism for actuating a charging or fueling flap on a charging or fueling compartment received on or in a body component of a vehicle, wherein the charging or fueling flap is reversibly movable between a closed position and an open position, wherein a flap lock is provided for locking the charging or fueling flap in its closed position. The actuating mechanism includes a drive having a drive shaft, which is operatively connectable to the charging or fueling flap such that, upon rotation of the drive shaft, the charging or fueling flap is movable relative to the charging or fueling compartment. The actuating mechanism further includes a mechanical control or switching mechanism, which is configured such that, upon rotation of the drive shaft to manipulate the flap lock, a rotational movement of the drive shaft can be tapped with the aid of the mechanical control or switching mechanism.

Abstract: The present disclosure relates to a bearing arrangement for supporting a shaft, in particular a shaft of a gearing mechanism for an electromechanical brake booster, having: at least one bearing, a shaft, which is at least section-wise accommodated in the at least one bearing and has a protruding, rounded region on at least one of its axial end surfaces, at least one spring element, that engages the protruding, rounded region in order to prestress the shaft in the axial direction.

Abstract: The invention relates to an assembly for a vehicle brake system, which comprises at least one brake cylinder and an electromechanical brake booster, having a drive arrangement for driving at least one actuating device designed for actuating a brake cylinder, wherein the drive arrangement has at least one electric motor and a gear mechanism for coupling the electric motor to the at least one actuating device, wherein at least one fastening device is provided for fastening the assembly to a vehicle, said fastening device defining a fastening plane. According to the invention the rotary shaft of the electric motor is arranged perpendicular to the longitudinal axis of the actuating device and at an angle of between 60° and 120° to the fastening plane.

Abstract: The electromechanical brake force booster for a vehicle brake system comprises a drive arrangement for driving at least one actuating device which is designed for actuating a brake cylinder. The drive arrangement has at least one electric motor and a gearing for coupling the electric motor to the at least one actuating device. The gearing comprises at least one second spur gear and at least one first spur gear. Furthermore, the gearing has an intermediate gearing stage. The intermediate gearing stage couples the electric motor to the second spur gear and to the first spur gear in torque-transmitting fashion. The intermediate gearing stage drives the second spur gear directly and the first spur gear via at least one intermediate gear.

Abstract: The present disclosure relates to a bearing arrangement for supporting a shaft, in particular a shaft of a gearing mechanism for an electromechanical brake booster, having: at least one bearing, a shaft, which is at least section-wise accommodated in the at least one bearing and has a protruding, rounded region on at least one of its axial end surfaces, at least one spring element, that engages the protruding, rounded region in order to prestress the shaft in the axial direction.

Abstract: The invention relates to an assembly for a vehicle brake system, which comprises at least one brake cylinder and an electromechanical brake booster, having a drive arrangement for driving at least one actuating device designed for actuating a brake cylinder, wherein the drive arrangement has at least one electric motor and a gear mechanism for coupling the electric motor to the at least one actuating device, wherein at least one fastening device is provided for fastening the assembly to a vehicle, said fastening device defining a fastening plane. According to the invention the rotary shaft of the electric motor is arranged perpendicular to the longitudinal axis of the actuating device and at an angle of between 60° and 120° to the fastening plane.

Abstract: The electromechanical brake force booster for a vehicle brake system comprises a drive arrangement for driving at least one actuating device which is designed for actuating a brake cylinder. The drive arrangement has at least one electric motor and a gearing for coupling the electric motor to the at least one actuating device. The gearing comprises at least one second spur gear and at least one first spur gear. Furthermore, the gearing has an intermediate gearing stage. The intermediate gearing stage couples the electric motor to the second spur gear and to the first spur gear in torque-transmitting fashion. The intermediate gearing stage drives the second spur gear directly and the first spur gear via at least one intermediate gear.

Abstract: Provided herein are methods for identifying a risk of low BMD in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating low BMD-related disorders, such as osteoporosis, and therapeutic and preventative methods applicable to osteoporosis. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

Abstract: Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing diseases or disorders, such as those related to signal transduction and/or cardiovascular disease. Methods of determining susceptibility to morbidity and/or increased or early mortality are also provided.

Abstract: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

Abstract: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

Abstract: Provided herein are methods for identifying risk of melanoma in a subject and/or subjects at risk of melanoma, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, therapeutic methods for treating melanoma in a subject and compositions comprising one or more melanoma cells and one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed agents. These embodiments are based upon an analysis of polymorphic variations in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, exemplified by nucleotide sequences of SEQ ID NO: 1-17.

Abstract: Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.