Abstract: Shift drum (10; 10?) for a multi-step transmission of a motor vehicle, with at least one circumferential track (14, 16), in particular circumferential groove (14, 16), into which at least one axially displaceable track follower (S, T) can engage, the circumferential track (14, 16) having flanks (22, 24) along which the track follower (S, T) is guided, characterized in that one of the flanks (22) has a portion (26) which is mounted so as to be movable axially out of a normal position against a restoring force (FR).

Abstract: A step variable transmission for a motor vehicle has a plurality of forward gear stages and at least one reverse gear stage. The transmission comprising: a drive input shaft arrangement, a drive output shaft arrangement, and a plurality of wheel sets which have loose wheels and shift wheels, wherein the shift wheels are rotatably mounted on a shaft arrangement and can be rotationally fixedly connected to the associated shaft arrangement by means of respective shift clutches.

Abstract: Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.

Abstract: Shift drum (10; 10?) for a multi-step transmission of a motor vehicle, with at least one circumferential track (14, 16), in particular circumferential groove (14, 16), into which at least one axially displaceable track follower (S, T) can engage, the circumferential track (14, 16) having flanks (22, 24) along which the track follower (S, T) is guided, characterized in that one of the flanks (22) has a portion (26) which is mounted so as to be movable axially out of a normal position against a restoring force (FR).

Abstract: A groove follower (70; 90) for cooperating with a shift groove (48) of a shift drum (44) of a multi-step transmission for a motor vehicle, the groove follower (70; 90) having a vertical crowning and a longitudinal crowning, and the shift groove (48) defining an active diameter along which the groove follower (70; 90) is to be guided in a state in which the groove follower (70; 90) engages into the shift groove (48), and the entirety of all the vertices (SHB) of the vertical crowning forming a guide curve (L) along the circumference of the groove follower, characterized in that the position of the vertices of the vertical crowning is selected such that the guide curve (L) corresponds essentially to the active diameter of the shift drum (44).

Abstract: The invention provides methods for inducing an immune response in a vertebrate host against a protozoan parasite, comprising administering to the host a live protozoan parasite that is genetically engineered to disrupt a stage-specific gene function that is required by the protozoan parasite to establish a secondary infection in the vertebrate host. Representative protozoan parasites belong to the phyla Apicomplexa and Kinetoplastida. The vertebrate host may be a mammal or a bird.

Abstract: The present invention relates to the treatment and prevention of malaria infection. In particular, the present invention provides novel noninfectious, whole organism vaccines for malaria, which vaccines comprise a Plasmodium axenic liver stage. The invention also provides methods to treat and prevent malaria by administering such Plasmodium axenic liver stage vaccines, as well as methods to generate Plasmodium axenic liver stages.

Abstract: Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.

Abstract: The present invention relates to DNA segments encoding MAEBL, an erythrocyte binding protein of a Plasmodium parasite, to substantially pure MAEBL proteins and to recombinantly or synthetically produced MAEBL molecules. The MAEBL proteins can be utilized as a vaccine for humans against malaria.