Abstract: An intra-ventricular pulsatile assist system is provided including an intra-ventricular blood pump including a chamber having a distal portion and a proximal portion opposite the distal portion, the proximal portion and the distal portion defining an axis extending therebetween and the distal portion defining an outlet; a valve at the distal portion of the chamber, the valve including a closed position in which the outlet is sealed and an open position in which the outlet is unsealed; and a control circuit including a processor in communication with the blood pump, the processor having processing circuitry configured to determine a pressure value in the chamber and transition the valve between the closed position and the open position when the pressure value in the chamber deviates from a predetermined threshold value.

Abstract: An intracardiac ventricular pacemaker is configured to detect an atrial mechanical event from a motion sensor signal received by an atrial event detector circuit of the pacemaker. The motion sensor signal is responsive the motion of blood flowing in the ventricle. A pacing pulse is scheduled at an expiration of a pacing interval set by a pace timing circuit in response to detecting the atrial mechanical event. An atrial-synchronized ventricular pacing pulse is delivered upon expiration of the pacing interval.

Abstract: An intracardiac ventricular pacemaker is configured to detect an atrial mechanical event from a motion sensor signal received by an atrial event detector circuit of the pacemaker. The motion sensor signal is responsive the motion of blood flowing in the ventricle. A pacing pulse is scheduled at an expiration of a pacing interval set by a pace timing circuit in response to detecting the atrial mechanical event. An atrial-synchronized ventricular pacing pulse is delivered upon expiration of the pacing interval.