Patents by Inventor Stefan Kreusch
Stefan Kreusch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11896975Abstract: The invention having functional vertical disposable reaction systems having a vertically mounted semipermeable membrane for sample preparation, chemical reactions, dialysis, enzymatic/microbiological fermentation, multistage processes, in vitro protein biosynthesis on a laboratory scale, formed from a base body and an exchangeable lid having different functions. For exchange across the membrane, the system is placed vertically into an outer volume consisting of gas, liquid or solid constituents. The system consists of a dimensionally stable base body and a liquid-tight lid having a functional support going toward the base of the base body, the dimensionally stable base body forming at least one noncapillary reaction space as inner volume with at least one semipermeable membrane as lateral wall. The high flexibility in use results from the combination of variants of the base bodies with different lid variants for different areas of use.Type: GrantFiled: January 30, 2019Date of Patent: February 13, 2024Assignee: Scienova GmbHInventors: Stefan Kreusch, Thomas Richter, Raffael Rubick
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Publication number: 20210053055Abstract: The invention having functional vertical disposable reaction systems having a vertically mounted semipermeable membrane for sample preparation, chemical reactions, dialysis, enzymatic/microbiological fermentation, multistage processes, in vitro protein biosynthesis on a laboratory scale, formed from a base body and an exchangeable lid having different functions. For exchange across the membrane, the system is placed vertically into an outer volume consisting of gas, liquid or solid constituents. The system consists of a dimensionally stable base body and a liquid-tight lid having a functional support going toward the base of the base body, the dimensionally stable base body forming at least one noncapillary reaction space as inner volume with at least one semipermeable membrane as lateral wall. The high flexibility in use results from the combination of variants of the base bodies with different lid variants for different areas of use.Type: ApplicationFiled: January 30, 2019Publication date: February 25, 2021Inventors: Stefan KREUSCH, Thomas RICHTER, Raffael RUBICK
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Patent number: 10272433Abstract: A reaction vessel for a vertical operating position geometrically bits into a standard receiving vessel providing an outer volume, for example a centrifuge tube, microplates and deep well plates. The reaction vessel including at least one upper opening with a seal element for reversible sealing for typical liquid handling techniques for filling, emptying mixing and gassing; at least one upper opening for pressure balancing and overrun; and a form stable body which forms at least one non capillary reaction cavity as an inner volume with at least one semipermeable membrane as a side wall. The at least one upper opening with the seal element for reversible sealing for standard liquid handling for filling, emptying, mixing and gassing leads through at least one capillary channel in the form stable body vertically into a lower portion of the reaction vessel and forms an opening at this location.Type: GrantFiled: March 31, 2015Date of Patent: April 30, 2019Assignee: Scienova GmbHInventors: Stefan Kreusch, Raffael Rubick, Claudia Macha
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Publication number: 20160001285Abstract: A reaction vessel for a vertical operating position geometrically bits into a standard receiving vessel providing an outer volume, for example a centrifuge tube, microplates and deep well plates. The reaction vessel including at least one upper opening with a seal element for reversible sealing for typical liquid handling techniques for filling, emptying mixing and gassing; at least one upper opening for pressure balancing and overrun; and a form stable body which forms at least one non capillary reaction cavity as an inner volume with at least one semipermeable membrane as a side wall. The at least one upper opening with the seal element for reversible sealing for standard liquid handling for filling, emptying, mixing and gassing leads through at least one capillary channel in the form stable body vertically into a lower portion of the reaction vessel and forms an opening at this location.Type: ApplicationFiled: March 31, 2015Publication date: January 7, 2016Inventors: Stefan KREUSCH, Raffael RUBICK, Claudia MACHA
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Patent number: 8758706Abstract: A device is provided by means of which biomolecules in samples in a volume range from <1 ?l to 500 ?l can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane.Type: GrantFiled: March 7, 2008Date of Patent: June 24, 2014Assignee: SCIENOVA GmbHInventors: Heidrun Rhode, Stefan Kreusch, Helga Endmann, Michael Händel, Günther Sammler, Edith Zimmermann
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Publication number: 20110163023Abstract: The invention relates to a device for the equilibrium dialysis of fluids having small volumes. The object of the invention of creating a device for equilibrium dialysis , the device being designed as a simple as possible, being universally usable and reliable in the use thereof, with which a large ratio of the membrane surface to the sample volume is created and which facilitates very short diffusion paths inside the sample as well as low sample losses, even with small sample volumes, is achieved in that a device is proposed, which comprises corresponding capillaries (1, 1?), which are connected through a membrane (2) and each are open at the ends on both sides, said capillaries for dialysis purposes each comprising a preferably substantially U-shaped arched capillary portion, and the at least one opening (4, 4?) thereof being provided each with a sealing element for introducing and/or removing the liquid.Type: ApplicationFiled: April 1, 2009Publication date: July 7, 2011Applicant: SCIENOVA GMBHInventors: Stefan Kreusch, Robert Fleischhauer, Maximilian Bauer, Carlotta Werner
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Publication number: 20100136596Abstract: A device is provided by means of which biomolecules in samples in a volume range from <1 ?l to 500 ?l can be received, treated and stored in a quick, reproducible and loss-free manner as easily, effortlessly and practically as possible, and without any risk of damaging the device. The device includes sample vessels that are configured, in terms of size and shape, as dimensionally and positionally stable capillaries that are open at both ends, the longitudinal walls of which are completely or partially made of a semi-permeable membrane.Type: ApplicationFiled: March 7, 2008Publication date: June 3, 2010Inventors: Heidrun Rhode, Stefan Kreusch, Helga Endmann, Michael Haendel, Guenther Sammler, Edith Zimmermann
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Publication number: 20050019774Abstract: The invention elates to a device for the simultaneous dialysis of a number of fluid samples, comprising a vessel for the dialysis fluid, with an inlet and outlet, a fill-level regulation and a sample plate (3) with a number of similar sample vessels (5) of ?l range size, arranged in a raster (n×8×12), the upper ends of which are open and the lower ends of which are sealed by a semi-permeable membrane (7) lying in a plane. In the raster region of the sample vessels (5), the sample plate has no regions or elements which extend beyond the plane of the membrane (7), or which form or support gas barriers after dipping in the dialysis fluid (2). The sample plate (3) comprises elements in the boundary region thereof for the escape of air after dipping in the dialysis fluid. Both sample fluids and dialysis fluids are agitated.Type: ApplicationFiled: December 10, 2002Publication date: January 27, 2005Inventors: Anton Horn, Stefan Kreusch, Gunther Sammler, Renate Bublitz, Sina Schwedler
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Patent number: 6698470Abstract: An airbag cover is defined by a predetermined breaking line which is introduced into a shaped flat material in a recessed manner. The recesses are achieved by removing material by means of laser radiation. According to the invention, the flat material is provided with a barrier layer. The barrier layer, by reason of its material properties, has greater resistance to removal of material by laser action than the material of the rest of the flat material. The recesses made by removing material extend along the predetermined breaking line in the flat material up to the barrier layer. The barrier layer makes it possible to produce a predetermined breaking line by means of laser machining which allows an exact residual wall thickness of the airbag cover in the area of the predetermined breaking line, so that the tearing strength can be adjusted very accurately, which is critically important for a reliable deployment of an airbag.Type: GrantFiled: July 1, 2002Date of Patent: March 2, 2004Assignee: CyBio Instruments GmbHInventors: Anton Horn, Stefan Kreusch, Thomas Moore, Guenther Sammler, Guenter Ditze