Abstract: The invention concerns a spindle drive for a closing element (3) of a motor vehicle (4), wherein in a drive train (14) of the spindle drive (1), a drive unit (5) is provided together with a spindle-nut gear (11) located drivingly downstream of the drive unit (5), with geometric spindle axis (A) running in the axial direction (X), in order to generate linear drive movements of a spindle-side drive connection (12a) relative to a nut-side drive connection (12b) between a retracted position and an extended position of the spindle drive (1), wherein in the drive train (14) a nominal break point (17) is provided which separates the drive train (14) at a predetermined axial limit load acting on the spindle drive (1) via the drive connections (12a, 12b), in particular a tensile load in the direction of the extension position. It is proposed that the drive train (14) is separated via the nominal break point (17) between the drive unit (5) and the spindle-nut gear (11).

Abstract: An electrosurgical generator includes a control unit, an electrosurgical function unit, and a user interface unit, wherein the electrosurgical function unit is configured to provide an electrosurgical therapy signal to one or more electrosurgical devices, the control unit is configured to control operation of the electrosurgical function and user interface units, and the user interface unit is configured to receive status information data from the control unit and to output that information to a user and allow input of user input data and to communicate that data to the control unit; wherein the user interface unit includes a proximity sensor configured to detect the presence of a user within a predetermined proximity of the user interface unit and to output a detection signal to the control unit, and the control unit is configured to switch the electrosurgical generator between first and second operational modes in response to the signal.

Abstract: An arrangement of a separate functional element of a washing fluid reservoir on a corresponding fixing portion of a structural component of a motor vehicle, wherein the fixing portion is at least partially formed from a plastics material, and wherein an opening is formed in the fixing portion in such a manner that an insertion portion of the functional element can be brought into a final installation position by insertion and sliding and/or rotation in a direction transverse to the depth direction of the opening, wherein, in the final installation position, the functional element is positively fixed in relation to the structural component, as viewed in the depth direction of the opening. The invention also relates to a motor vehicle having such an arrangement, to a filling nozzle for a washing fluid reservoir, to a motor vehicle hood latch support with a fixing portion, and to a method for installing a functional element on a fixing portion.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: The invention relates to a combination therapy for the treatment of tumors and tumor metastases comprising administration of integrin ligands, preferably integrin antagonists, together with co-therapeutic agents or therapy forms that have synergistic efficacy when administered consecutively with said ligands, such as chemotherapeutic agents and or radiation therapy. The therapy results in a synergistic potential increase of the inhibition effect of each individual therapeutic on tumor cell proliferation, yielding more effective treatment than found by administering an individual component alone, concurrently or not in the dosage regime of the present invention.

Abstract: A plumbing fixture is provided that comprises substantially a housing, which has connections for a cold and hot water supply and an outlet for mixed water, and a water conduit module, which has a preformed hollow section and at least one inlet for cold, hot, or mixed water. The housing can be connected as a single piece and the water conduit module sealingly with the housing.