Abstract: Non-nucleoside reverse transcriptase inhibitors of formula (P-1) wherein: Ar1 is an unsaturated, optionally substituted, mono or bicyclic ring structure comprising 0 to 3 hetero atoms selected from S, O and N; Ar2 is an aromatic, optionally substituted, monocyclic ring structure comprising at least one nitrogen hetero atom and zero to two further hetero atoms selected from S, O and N; R4 and R5 are independently H or C3-C8 cycloalkyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C5 alkoxy, C1-C4 alkanoyloxy, C1-C4 alkylthio, amino, carboxy, carbamoyl, cyano, halo, hydroxy, aminomethyl, hydroxymethyl, carboxymethyl, or halo substituted C1-C6 alkyl mercapto, nitro; or R4 and RS join to form a 3-6 membered, optionally substituted ring structure; R6 is 0 or S; Rx is the residue of a natural or unnatural amino acid; and L* is a linker moiety which is ether-, carbonate- or ester-bound to the adjacent oxygen and ester linked to Rx; and pharmaceutically acceptable salts thereof are anti-HIV agents with favourable ph

Abstract: A hydromechanical chuck intended to be mounted, with one end thereof, in a machine, such as a drilling machine, milling machine, lathe machine etc. and, with the opposite end thereof to releasably hold a shaft tool like a drill, a milling tool, a rotary saw blade, or a rotary grinding roll. The hydromechanical chuck is formed as a cone coupling chuck comprising a inner sleeve which can change is radial dimensions and has a central bore for receiving the shaft of a shaft tool. The inner sleeve is adapted for being radially compressed against the tool shaft. The hydromechanical chuck has a solid outer sleeve which is axially displaceable on the inner sleeve. The inner sleeve and outer sleeve are formed with a matching cone surface, which, upon a displacement of the outer sleeve on the inner sleeve, provides a radial compression of the inner sleeve.

Abstract: A rotating holder for tools or work pieces includes a chuck in the form of a hydraulic clamp bushing. The clamp bushing comprises a thin inner sleeve or wall, a solid outer sleeve and a plastic or hydraulic pressure medium which is entrapped between the sleeves. The thin inner sleeve is arranged to both center and firmly clamp a rotating tool or work piece when the hydraulic pressure medium is being pressurized. The clamp bushing is integrated with a mounting cone or with a machine spindle by a welding or soldering joint. The clamp bushing is formed with a bore at the periphery thereof for providing an opening to some type of means for pressurizing the hydraulic pressure medium. A protection ring is formed around the periphery of the clamp bushing and is rotatable to at least two positions, in one position of which the protection ring covers the bore for the pressurization means and in another position of which a passageway is opened to the pressurization means.