Patents by Inventor Stefan Lohmer
Stefan Lohmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10167281Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.Type: GrantFiled: June 18, 2017Date of Patent: January 1, 2019Assignee: Axxam S.P.A.Inventors: Paolo Pevarello, Stefan Lohmer, Chiara Llberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
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Publication number: 20170283409Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.Type: ApplicationFiled: June 18, 2017Publication date: October 5, 2017Applicant: Axxam S.P.A.Inventors: Paolo Pevarello, Stefan Lohmer, Chiara LIberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
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Patent number: 9718812Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.Type: GrantFiled: February 4, 2015Date of Patent: August 1, 2017Assignee: Axxam S.P.A.Inventors: Paolo Pevarello, Stefan Lohmer, Chiara Llberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
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Publication number: 20170008883Abstract: The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties. The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.Type: ApplicationFiled: February 4, 2015Publication date: January 12, 2017Applicant: Axxam S.P.A.Inventors: Paolo Pevarello, Stefan Lohmer, Chiara LIberati, Pierfausto Seneci, Cristina Pesenti, Adolfo Prandi
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Publication number: 20160198747Abstract: The present invention primarily relates to 1H-pyrrole-2,4-dicarbonyl- derivatives of Formula (I) wherein R1, R2, R3, Z. Z? and J are as defined in the description, to mixtures thereof and to the use thereof as flavoring agents. The compounds in accordance with the present invention are suitable for producing, imparting, or intensifying an umami flavor. The invention further relates to flavoring mixtures, compositions for oral consumption as well as ready-to-eat, ready-to-use and semifinished products, comprising an effective amount of the compound of Formula (I) or of a mixture of compounds of Formula (I) and to specific methods for producing, imparting, modifying and/or intensifying specific flavor impressions.Type: ApplicationFiled: July 15, 2014Publication date: July 14, 2016Inventors: Marcel Winning, Stefan Lohmer, Paolo Pevarello
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Publication number: 20090286695Abstract: It is described a stable recombinant stem cell able to express an apophotoprotein and produce a bioluminescent signal in the presence of a suitable chromophore as substrate in response to intracellular calcium concentration variation: methods for identifying agents modulating the differentiation of stem cells towards a specific cell lineage; methods for identifying a ligand able to stimulate a specific cell lineage target; methods for identifying an antagonist to ligand known to stimulate a specific cell lineage target uses of stable recombinant stem cells for in vitro testing of toxicity and/teratology of a substance.Type: ApplicationFiled: January 10, 2007Publication date: November 19, 2009Applicant: AXXAM S.P.A.Inventors: Silvia Cainarca, Cinzia Nucci, Sabrina Corazza, Stefan Lohmer
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Patent number: 7601805Abstract: Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.Type: GrantFiled: October 21, 2003Date of Patent: October 13, 2009Assignee: AXXAM S.R.L.Inventors: Maria Foti, Stefan Lohmer
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Publication number: 20070065818Abstract: Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.Type: ApplicationFiled: October 21, 2003Publication date: March 22, 2007Inventors: Maria Foti, Stefan Lohmer
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Publication number: 20020028940Abstract: The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.Type: ApplicationFiled: April 23, 2001Publication date: March 7, 2002Inventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 6235770Abstract: The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.Type: GrantFiled: November 8, 1999Date of Patent: May 22, 2001Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Müller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grützmann, Stefan Wohlfeil
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Patent number: 6200971Abstract: The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.Type: GrantFiled: October 18, 1999Date of Patent: March 13, 2001Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Müller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Gr{umlaut over (u )}tzmann, Stefan Wohlfeil
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Patent number: 6114341Abstract: The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.Type: GrantFiled: March 31, 1997Date of Patent: September 5, 2000Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Peter Eckenberg, Rudi Grutzmann, Hilmar Bischoff, Dirk Denzer, Stefan Wohlfeil, Stefan Lohmer, Ulrich Nielsch, Peter Kolkhof
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Patent number: 6034115Abstract: The indolyl-substituted phenylacetic acid derivatives are prepared by reacting the corresponding phenylacetic acids with the required amines. The indolyl-substituted phenylacetic acid derivatives are suitable as active compounds in medicaments, in particular in antiarteriosclerotic medicaments.Type: GrantFiled: December 9, 1996Date of Patent: March 7, 2000Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 6025378Abstract: The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.Type: GrantFiled: June 18, 1998Date of Patent: February 15, 2000Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5935983Abstract: The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.Type: GrantFiled: October 24, 1997Date of Patent: August 10, 1999Assignee: Bayer AktiengesellschaftInventors: Matthias Muller-Gliemann, Ulrich Muller, Martin Beuck, Siegfried Zaiss, Christoph Gerdes, Anke Domdey-Bette, Rudi Grutzmann, Stefan Lohmer, Stefan Wohlfeil, Ozkan Yalkinoglu, James Elting, Dirk Denzer
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Patent number: 5849751Abstract: Amides and sulphonamides of benzylamines having heterocyclic substituents are prepared by first converting the corresponding carboxylic acids into the corresponding amines and then substituting these on the amine nitrogen in a corresponding manner. The new amides and sulphonamides of benzylamines having heterocyclic substituents can be used as active compounds in medicaments, in particular in antiatherosclerotic medicaments.Type: GrantFiled: July 3, 1996Date of Patent: December 15, 1998Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Richard Connell, Hilmar Bischoff, Dirk Denzer, Stefan Lohmer, Stefan Wohlfeil, Rudi Grutzmann
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Patent number: 5811429Abstract: The bicyclic heterocyclic compounds are prepared by reaction of correspondingly substituted carboxylic acids with amines, in particular with phenylglycinolamine. The bicyclic heterocyclic compounds according to the invention are suitable as active compounds in medicaments, in particular in medicaments having an antiatherosclerotic action.Type: GrantFiled: December 9, 1996Date of Patent: September 22, 1998Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5714494Abstract: Substituted xanthines of formula ##STR1## in which A represents a radical of the formula ##STR2## in which R.sup.3, R.sup.4, R.sup.6 and R.sup.7 denote hydrogen, cycloalkyl, aryl having 6 to 10 carbon atoms, or denote straight-chain of branched alkyl or alkenyl, each of which is optionally substituted; T, V, X and Y are identical or different and denote an oxygen or sulphur atom; R.sup.5 and R.sup.8 are identical or different and denote hydrogen, halogen, cycloalkyl having 3 to 8 carbon atoms or straight-chain or branched alkyl or alkenyl in each case having up to 8 carbon atoms, optionally substituted or R.sup.5 and R.sup.8 denote aryl having 6 to 10 carbon atoms or a 5- to 7-membered aromatic, optionally benzo-fused heterocycle having up to 3 heteroatoms S, N and/or O, each of which is optionally substituted; L represents an oxygen or sulphur atom; R.sup.2 represents mercapto, hydroxyl, straight-chain or branched alkoxy having up to 8 carbon atoms or the group of the formula ##STR3## in which R.sup.Type: GrantFiled: September 18, 1996Date of Patent: February 3, 1998Assignee: Bayer AktiengesellschaftInventors: Richard Connell, Siegfried Goldmann, Ulrich Muller, Stefan Lohmer, Hilmar Bischoff, Dirk Denzer, Rudi Grutzmann, Stefan Wohlfeil
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Patent number: 5607962Abstract: Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and restenosis.Type: GrantFiled: January 25, 1996Date of Patent: March 4, 1997Assignee: Bayer AktiengesellschaftInventors: Matthias M uller-Gliemann, Ulrich M uller, Martin Beuck, Siegfried Zaiss, Christoph Gerdes, Anke Domdey-Bette, Rudi Gr utzmann, Stefan Lohmer, Stefan Wohlfeil, Ozkan Yalkinoglu, James Elting, Dirk Denzer