Abstract: The disclosure relates to medical devices and methods of manufacturing medical devices. An orthopedic screw includes an inner core member having a head having a first outer diameter, a tip having a second outer diameter, and a body extending between the head and the tip and having a third outer diameter that is less than the first outer diameter and the second outer diameter. An outer body member is disposed circumferentially around the body of the inner core member and defines an outer body member external thread. The tip of the inner core member can define an inner core member external thread that forms an interrupted thread with the outer body member external thread.

Abstract: A motor vehicle shell of a motor vehicle includes a frame structure that is formed by crossmembers and by longitudinal members. The frame structure is closed peripherally and protrudes downwardly in a vertical direction of the motor vehicle from a base element. A receiving chamber for receiving an electrical energy store is delimited by the frame structure. A cover is formed separately from the frame structure and is disposed opposite the base element. The receiving chamber is closed downwardly in the vertical direction of the motor vehicle by the cover. An annular and dimensionally stable intermediary element is formed separately from the frame structure and separately from the cover. The intermediary element is disposed between the frame structure and the cover and the intermediary element is fixed at least in a liquid-tight manner on the frame structure by a firmly bonded connection.

Abstract: A display device for representing information on a display includes at least one display module and at least one cover glass, wherein mechanical insulation is arranged between the display module and the cover glass, and at least one actuator is designed to induce a movement of the display.

Abstract: A display device for representing information on a display includes at least one display module and at least one cover glass, wherein mechanical insulation is arranged between the display module and the cover glass, and at least one actuator is designed to induce a movement of the display.

Abstract: The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the prevention and curative treatment of an inflammatory pulmonary disease.

Abstract: The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the prevention and curative treatment of an inflammatory pulmonary disease.

Abstract: The invention relates to the combination of a pulmonary surfactant and a TNF-derived peptide and its use for the treatment of respiratory disease.

Abstract: The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and protein engineering.

Abstract: Electrode milling cutter for machining spot welding electrodes, said electrode milling cutter having one or more milling edges, wherein at least one of the milling edges is interrupted by one or more cut-outs at one or more points. The invention also relates to a milling device and to an apparatus for subsequently machining spot welding electrodes.

Abstract: A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

Abstract: Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or analog thereof, and a modified sugar moiety that differs in structure from a sugar moiety of a naturally occurring nucleoside. In embodiments, the fNAs of the present disclosure are analogues of NA prodrugs used to treat viral disorders. Embodiments of the present disclosure also include methods of making the novel fNAs of the present disclosure.

Abstract: The invention relates to the combined use of a PDE4 inhibitor with a HMG-CoA reductase inhibitor for the preventive and curative treatment of an inflammatory pulmonary disease.

Abstract: A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

Abstract: A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

Abstract: A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

Abstract: The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and protein engineering.

Abstract: The invention relates to the combination of a pulmonary surfactant and a TNF-derived peptide and its use for the treatment of respiratory disease.

Abstract: The invention relates to the use of roflumilast for the prophylaxis of or the treatment of emphysema.

Abstract: The invention relates to the combined administration of a pulmonary surfactant and a PDE5 inhibitor for the treatment of a disease in which pulmonary surfactant malfunction and/or phosphodiesterase 5 (PDE5) activity is detrimental.