Patents by Inventor Stefan Margraf
Stefan Margraf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11185827Abstract: A surface-modified filter membrane for filtering blood, in particular for separating blood plasma and blood serum, and a method for the production thereof, a filter provided therewith and the use thereof.Type: GrantFiled: July 16, 2018Date of Patent: November 30, 2021Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Christoph Weber, Heinz Schoeder, Jens Altrichter, Roland Kirchner, Stefan Margraf, Michael Scholl
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Patent number: 10406271Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.Type: GrantFiled: December 9, 2015Date of Patent: September 10, 2019Assignee: Leukocare AGInventors: Stefan Margraf, Martin Scholz
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Publication number: 20190046715Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Inventors: Stefan Margraf, Martin Scholz
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Publication number: 20190015790Abstract: A surface-modified filter membrane for filtering blood, in particular for separating blood plasma and blood serum, and a method for the production thereof, a filter provided therewith and the use thereof.Type: ApplicationFiled: July 16, 2018Publication date: January 17, 2019Applicant: Boehringer Ingelheim Vetmedica GmbHInventors: Christoph Weber, Heinz Ulrich Gerhard Schoeder, Jens Altrichter, Roland Kirchner, Stefan Margraf, Michael Scholl
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Publication number: 20180318471Abstract: The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced opening before use, comprising the application of a viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.Type: ApplicationFiled: July 13, 2018Publication date: November 8, 2018Applicant: Solvamed GmbHInventors: Stefan Margraf, Jan Stange
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Patent number: 10052414Abstract: The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced bodily opening before use, comprising the application of a preferably viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.Type: GrantFiled: January 22, 2013Date of Patent: August 21, 2018Assignee: Solvamed GmbHInventors: Stefan Margraf, Jan Stange
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Publication number: 20180204137Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the compositions according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: ApplicationFiled: October 18, 2017Publication date: July 19, 2018Inventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Patent number: 9926383Abstract: The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.Type: GrantFiled: May 7, 2007Date of Patent: March 27, 2018Assignee: LEUKOCARE AGInventors: Stefan Margraf, Martin Scholz
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Patent number: 9797895Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: GrantFiled: March 31, 2010Date of Patent: October 24, 2017Assignee: Leukocare AGInventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Publication number: 20160082174Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.Type: ApplicationFiled: December 9, 2015Publication date: March 24, 2016Inventors: Stefan Margraf, Martin Scholz
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Publication number: 20140370067Abstract: The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced bodily opening before use, comprising the application of a preferably viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.Type: ApplicationFiled: January 22, 2013Publication date: December 18, 2014Inventors: Stefan Margraf, Jan Stange
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Publication number: 20120118825Abstract: The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.Type: ApplicationFiled: June 17, 2010Publication date: May 17, 2012Applicant: Leukocare AGInventors: Stefan Margraf, Martin Scholz
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Publication number: 20120107829Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: ApplicationFiled: March 31, 2010Publication date: May 3, 2012Applicant: LEUKOCARE AGInventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Publication number: 20100291665Abstract: The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.Type: ApplicationFiled: November 7, 2008Publication date: November 18, 2010Applicant: LEUKOCARE AGInventors: Stefan Margraf, Martin Scholz, Jens Altrichter
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Publication number: 20100261223Abstract: A device and a method for detecting components in blood, in particular for determining the concentration of components in blood or water is provided. Moreover, a use of a device and/or a method for determining components in blood is provided and a kit including the device and a fluorescence standard.Type: ApplicationFiled: October 31, 2008Publication date: October 14, 2010Inventors: Stefan Margraf, Martin Scholz
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Publication number: 20090298078Abstract: The present invention relates to a method for the detection of an activation of the immune system, preferably in the sense of an NET formation, or the extent of cell death in a non-tumorous tissue or in a body fluid, wherein free DNA is measured in a sample from an individual. Furthermore, the invention relates to a method for the production of a kit for the detection of an activation of the immune system or the extent of cell death in an individual, comprising the packaging of a fluorescent dye and a DNA standard in at least one container.Type: ApplicationFiled: October 1, 2007Publication date: December 3, 2009Applicant: Leukocare AGInventor: Stefan Margraf
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Publication number: 20090269778Abstract: The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.Type: ApplicationFiled: May 7, 2007Publication date: October 29, 2009Applicant: LEUKOCARE AGInventors: Stefan Margraf, Martin Scholz