Patents by Inventor Stefan Mullner

Stefan Mullner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6036948
    Abstract: Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals.alpha.- or .beta.-linked polyaspartamide derivatives of the formula I ##STR1## in which R.sup.I, R.sup.II, R.sup.III, R.sup.IV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: March 14, 2000
    Inventors: Volker Krone, Axel Walch, Stefan Mullner, Ernold Granzer
  • Patent number: 6011051
    Abstract: Compounds of the formula I or II ##STR1## are suitable for the production of pharmaceuticals for the modulation of apoptosis. These compounds can be employed for the treatment of infarct, stroke, neurodegeneration or hypertrophic disorders.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: January 4, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Claudia Dax
  • Patent number: 5990103
    Abstract: A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca.sup.2+ content, is suitable for the treatment of immunological diseases.
    Type: Grant
    Filed: February 25, 1997
    Date of Patent: November 23, 1999
    Assignee: Hoechst Aktiengesllschaft
    Inventors: Martin Schonharting, Stefan Mullner, Peter Zabel
  • Patent number: 5981536
    Abstract: Compounds of the formula I ##STR1## where one of the radicals R.sup.1 and R.sup.3 is a radical of the formula II --(CH.sub.2).sub.n --A--CH.sub.3 (II) in which A is a covalent bond,--C(O)-- or --C(R.sup.4)(OH)--, are suitable for the production of pharmaceuticals for the modulation of apoptosis. A combination preparation comprising a compound of the formula I and a compound of the formula IV and/or V ##STR2## is suitable for the production of pharmaceuticals for the modulation of apoptosis.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Claudia Dax
  • Patent number: 5976811
    Abstract: Antibodies for the selective immunological determination of bile acids in biological matricesPolyclonal antibodies for the selective immunological determination of bile acids in biological matrices, a process for the preparation of these antibodies, and their use in immunoassays are described.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: November 2, 1999
    Assignee: Hoescht Aktiengesellschaft
    Inventors: Stefan Mullner, Axel Hoffmann
  • Patent number: 5977151
    Abstract: A compound of the formula ##STR1## where R.sup.1 is the radical of the formula II or III ##STR2## is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV ##STR3## is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Bernd Kirschbaum, Wilfried Schwab
  • Patent number: 5856330
    Abstract: Compounds of the formula I ##STR1## where one of the radicals R.sup.1 and R.sup.3 is a radical of the formula II --(CH.sub.2).sub.n --A--CH.sub.3 (II) in which A is a covalent bond, --C(O)-- or --C(R.sup.4)(OH)--, are suitable for the production of pharmaceuticals for the modulation of apoptosis. A combination preparation comprising a compound of the formula I and a compound of the formula IV and/or V ##STR2## is suitable for the production of pharmaceuticals for the modulation of apoptosis.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: January 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Claudia Dax
  • Patent number: 5780592
    Abstract: A composition comprising lipoproteins and a compound of the formula I ##STR1## stereoisomeric form or salt thereof, suitable for the treatment of immunological disorders, cancer or in transplantation.
    Type: Grant
    Filed: December 10, 1996
    Date of Patent: July 14, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Axel Hofmann, Karin Saar, Hans-Ulrich Schorlemmer, Robert Bartlett
  • Patent number: 5750679
    Abstract: A process for obtaining pharmacologically active compounds from complex mixtures of substancesFree organic acids, hydroxy acids, fatty alcohols, sugars and hydroxy-substituted steroids are obtained from complex mixtures of substances by mixing the material to be extracted with a polar solvent, drying the resulting mixture, subsequently silylating, esterifying or acylating, and extracting the resulting material with a supercritical fluid under a pressure of more than 200 bar.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: May 12, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Peter Haas, Heinz Engelhardt, Stefan Mullner
  • Patent number: 5728686
    Abstract: Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmaceuticalsA compound of the formula ##STR1## where R.sup.1 and R.sup.3 are identical or different and at least one of the radicals R.sup.1 and R.sup.3 is a radical of the formula XI ##STR2## in which E is a covalent bond or a (C.sub.1 -C.sub.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: March 17, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunter Billen, Ismahan Okyayuz-Baklouti, Hiristo Anagnostopulos, Stefan Mullner
  • Patent number: 5714138
    Abstract: Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals.alpha..sup.- or .beta.-linked polyaspartamide derivatives of the formula I ##STR1## in which R.sup.I R.sup.II, R.sup.III, R.sup.IV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: February 3, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Krone, Axel Walch, Stefan Mullner, Ernold Granzer
  • Patent number: 5624903
    Abstract: Phosphoinositol-glycan-peptide with insulin-like actionPhosphoinositol-glycan-peptides obtainable by cleavage of adenosine 3',5'-cyclic monophosphate-binding protein, which contain glucosamine, galactose, mannose, inositol, phosphoric acid, ethanolamine and a peptide with the sequence Asx-Cys-Tyr, the preparation and use thereof for the treatment of diabetes mellitus and non-insulin-dependent diabetes are described.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: April 29, 1997
    Assignee: Heochst Aktiengesellschaft
    Inventors: Gunter Muller, Dominique Tripier, Stefan Mullner
  • Patent number: 5514599
    Abstract: Antibodies against highly conserved amino acid sequences of immunogenic substances, a process for the preparation of these antibodies and the use thereof in immunoassays.The invention relates to antibodies which are obtained by immunization with a peptide fragment which represents a highly conserved amino acid sequence of a native protein. The antibodies according to the invention can be used for the preparation of immunoassays, in particular for the preparation of assays for the determination of genetically engineered products such as insulin which arise as sparingly soluble inclusion bodies in microorganisms. The invention particularly relates to a multispecies insulin assay in the form of an RIA.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: May 7, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Stefan Mullner
  • Patent number: 5461035
    Abstract: A method for the treatment of diabetes mellitus or non-insulin-dependent diabetes comprising at least one peptide selected from the group consisting of Tyr-Gln-Leu-Glu-Asn-Tar-Cys-Asn, Acetyl-Leu-Glu-Asn-Tar-Cys-Asn OH, Asn-Tar-Cys-Asn, or a peptide of the formulaX-Q-Cys-D (II)or the stereoisomeric forms of the peptide of formula II, or the physiologically tolerated salts of the peptide of the formula II.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: October 24, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Wolfgang Konig, Gunter Muller
  • Patent number: 5430116
    Abstract: Polymeric and oligomeric bile acids are described which can be prepared by polymerization of monomeric bile acids of the formula IG--X--A (I)in which G, X and A have the given meanings or by copolymerization with a monomer of the formula IV ##STR1## in which R.sup.9 and R.sup.10 have the given meanings, or by copolymerization with N-vinylpyrrolidone or its derivatives,and/or by copolymerization with ethylenically unsaturated dicarboxylic anhydrides and ethylenically unsaturated dicarboxylic acids each having 2 to 6 carbon atoms; their esters or half esters, alkyl esters having 1-6 carbon atoms, cycloalkyl esters having 5 to 8 carbon atoms, benzyl esters or phenyl esters being understood as esters. They can be used as pharmaceuticals, foodstuff additives, formulation auxiliaries and detergents.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: July 4, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Kramer, Stefan Mullner, Matthias Gutweiler, Matthias Kroggel
  • Patent number: 5430110
    Abstract: Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary.Polyvinylamine derivatives containing hydrophilic centers, of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X, w, x, y and z have the meanings given, and a process for their preparation, and the use of these compounds as medicaments, active compound carriers and foodstuff auxiliaries are described. Highly pure polyvinylamines having the recurring unit of the formula Ia ##STR2## the preparation of which is likewise described, are used in particular as starting substances for the preparation.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: July 4, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Susanne Grabley, Ernold Granzer, Stefan Mullner, Axel Walch, Guan-Yu Xu
  • Patent number: 5428112
    Abstract: Crosslinked, nitrogen-containing vinyl copolymers having units of the formula I ##STR1## and physiologically tolerated salts thereof, in which, in formula I, A1, A2, R, w, x, y and z have the meanings given, a process for their preparation and the use of the compounds as medicaments, active compound carriers and foodstuff auxiliaries are described.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Ahlers, Heiner Glombik, Stefan Mullner, Axel Walch
  • Patent number: 5401498
    Abstract: The invention relates to a pharmaceutical containing an effective amount of a polyhydroxymethylene containing grafted ethoxylated alcohols and/or ethoxylated carboxylic acids.The pharmaceutical is used for the treatment of dyslipoproteinemias.
    Type: Grant
    Filed: March 25, 1993
    Date of Patent: March 28, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Kurt Kesseler, Rudolf Schmidtberger, Stefan Mullner, Ernold Granzer
  • Patent number: 5268272
    Abstract: Complexes which contain at least one glycosyl-phosphatidylinositol protein and at least one cholanic acid derivative of the formula I ##STR1## are suitable, inter alia, in enzyme tests and as aids in chemical reactions; where R.sup.1 is --NH--CH.sub.2 --CH.sub.2 --SO.sub.3 or --NH--CH.sub.2 --COOH, R.sup.2 is NR.sup.3 R.sup.4 or --OR.sup.5 ; R.sup.3, R.sup.4 or R.sup.5 are a hydrogen atom, (C.sub.1 -C.sub.5)-alkyl, (C.sub.3 -C.sub.6)-cycloalkyl, substituted acetyl, halogen, succinyl, substituted benzyl or substituted benzoyl.
    Type: Grant
    Filed: February 25, 1993
    Date of Patent: December 7, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Gunter Muller
  • Patent number: 5250524
    Abstract: The invention relates to bile acid derivatives of the formula IG1--X--G2 (I)in whichG1 and G2 are bile acid radicals or modified bile acid radicals in the form of the free acids, the esters or amides, the salt forms and also the forms derivatized on the alcohol groups andX is a bridge group or a single covalent bond, it being possible for G1 and G2 to be optionally bonded via X.The compounds according to the invention have a high affinity for the specific bile acid transport system of the small intestine and inhibit bile acid absorption in a concentration-dependent and competitive manner.
    Type: Grant
    Filed: December 4, 1991
    Date of Patent: October 5, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Kramer, Gunther Wess, Stefan Mullner, Horst Neubauer