Patents by Inventor Stefan Mundlos

Stefan Mundlos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1
    Publication number: 20180105860
    Abstract: The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 19, 2018
    Inventors: BRUNO REVERSADE, Stefan Mundlos
  • Muteins of the pyrroline-5-carboxylate reductase 1
    Patent number: 9862986
    Abstract: The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: January 9, 2018
    Assignee: Agency for Science, Technology and Research
    Inventors: Bruno Reversade, Stefan Mundlos
  • MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1
    Publication number: 20150240285
    Abstract: The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1, and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
    Type: Application
    Filed: December 24, 2014
    Publication date: August 27, 2015
    Inventors: BRUNO REVERSADE, STEFAN MUNDLOS
  • Growth factor mutants with improved biological activity
    Patent number: 9012401
    Abstract: The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 21, 2015
    Assignees: Biopharm Gesellschaft zur biotechnolgischen Entwicklung von Pharmaka mbH, Charite-Universitatsmedizin Berlin, Freie Universitat Berlin
    Inventors: Stefan Mundlos, Petra Knaus, Jens Pohl, Michael Kruse, Frank Plöger
  • Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
    Patent number: 8828937
    Abstract: The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: September 9, 2014
    Assignee: Haase Investments UG
    Inventors: Petra Seemann, Stefan Mundlos, Carsten Reissner, Georg Duda, Julia Zimmer
  • MUTEINS OF THE PYRROLINE-5-CARBOXYLATE REDUCTASE 1
    Publication number: 20120144511
    Abstract: The invention relates to muteins of the pyrroline-5-carboxylate reductase 1 (PYCR1), to nucleic acid molecules comprising a nucleotide sequence encoding such muteins, to methods of determining in a subject a predisposition of having an age related disorder associated with PYCR1, to methods of identifying a compound capable of modifying the expression of PYCR1 and methods of treating a subject having an age-related disorder associated with PYCR1. The invention further relates to a genetically modified animal and a method of modifying the expression of the PYCR1 gene in an animal.
    Type: Application
    Filed: May 26, 2010
    Publication date: June 7, 2012
    Applicant: Agency for Science, Technology and Research
    Inventors: Bruno Reversade, Stefan Mundlos
  • BONE MORPHOGENETIC PROTEIN 2 (BMP2) VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY
    Publication number: 20120058944
    Abstract: The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
    Type: Application
    Filed: March 11, 2010
    Publication date: March 8, 2012
    Inventors: Petra Seemann, Stefan Mundlos, Carsten Reissner, Georg Duda, Julia Zimmer
  • Growth Factor Mutants With Improved Biological Activitiy
    Publication number: 20080260830
    Abstract: The invention relates to novel biosynthetic growth factor mutants which exhibit improved biological activity.
    Type: Application
    Filed: March 3, 2006
    Publication date: October 23, 2008
    Applicants: CHARITE- UNIVERSITAETSMEDIZIN BERLIN, FREIE UNIVERSITAET BERLIN, BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWI
    Inventors: Stefan Mundlos, Petra Knaus, Jens Pohl, Michael Kruse, Frank Ploger