Patents by Inventor Stefan Oscarson
Stefan Oscarson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12187762Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: GrantFiled: September 10, 2019Date of Patent: January 7, 2025Assignees: The Regents of the University of California, University College DublinInventors: Stefan Oscarson, John Vincent Fahy, Irina Gitlin, Wilfred Raymond
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Patent number: 11850334Abstract: There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.Type: GrantFiled: October 3, 2019Date of Patent: December 26, 2023Assignee: Carmeda ABInventors: Dagmar Pikas, Johan Riesenfeld, Karin Leontein, Eva Koch, Stefan Oscarson
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Patent number: 11707519Abstract: Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.Type: GrantFiled: May 11, 2018Date of Patent: July 25, 2023Assignees: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, NATIONAL RESEARCH COUNCIL OF CANADAInventors: Andrew Cox, Janelle Sauvageau, Stefan Oscarson, Lorenzo Guazzelli
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Publication number: 20230181607Abstract: Disclosed herein, inter alia, are methods of using thiosaccharide compounds for treating coronavirus infection.Type: ApplicationFiled: May 11, 2021Publication date: June 15, 2023Applicants: The University of the Regents of California, University College DublinInventors: John Vincent Fahy, Irina Gitlin, Wilfred Raymond, Stefan Oscarson
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Publication number: 20210379253Abstract: There is provided inter alia an anticoagulant surface which surface has covalently bound thereto a plurality of fragments of heparin, wherein said fragments consist of 5-18 saccharide units and at least some of said plurality of fragments comprise polysaccharide sequence A, which surface catalyses the inhibition of FIIa and FXa by AT.Type: ApplicationFiled: October 3, 2019Publication date: December 9, 2021Inventors: Dagmar Pikas, Johan Riesenfeld, Karin Leontein, Eva Koch, Stefan Oscarson
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Publication number: 20210230202Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: ApplicationFiled: September 10, 2019Publication date: July 29, 2021Inventors: Stefan Oscarson, John Vincent Fahy, Irina Gitlin, Wilfred Raymond
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Patent number: 11021506Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: GrantFiled: November 22, 2019Date of Patent: June 1, 2021Assignees: The Regents of the University of California, University College DublinInventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Publication number: 20200215186Abstract: Processes for the preparation of phosphorylated heptose compounds are provided. Embodiments of the invention relate to the chemical synthesis of heptopyranose phosphate compounds. Also, embodiments of the invention relate to the use of compounds according to the invention in modulating an immune response in a subject.Type: ApplicationFiled: May 11, 2018Publication date: July 9, 2020Applicants: NATIONAL RESEARCH COUNCIL OF CANADA, UNIVERSITY COLLEGE DUBLINInventors: Andrew COX, Janelle SAUVAGEAU, Stefan OSCARSON, Lorenzo GUAZZELLI
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Publication number: 20200102340Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: ApplicationFiled: November 22, 2019Publication date: April 2, 2020Inventors: Stefan OSCARSON, John Vincent FAHY, Shaopeng YUAN, Stephen CARRINGTON
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Patent number: 10526359Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: GrantFiled: November 27, 2017Date of Patent: January 7, 2020Assignees: The Regents of the University of California, University College DublinInventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Publication number: 20180326118Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicant: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Patent number: 10064978Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: GrantFiled: September 19, 2014Date of Patent: September 4, 2018Assignee: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20180111955Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: ApplicationFiled: November 27, 2017Publication date: April 26, 2018Inventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Patent number: 9856283Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: GrantFiled: September 8, 2015Date of Patent: January 2, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Publication number: 20160060284Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: ApplicationFiled: September 8, 2015Publication date: March 3, 2016Inventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Patent number: 8992963Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: GrantFiled: September 15, 2009Date of Patent: March 31, 2015Assignee: Carmeda ABInventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20150045508Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: September 19, 2014Publication date: February 12, 2015Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Patent number: 8062641Abstract: An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.Type: GrantFiled: May 8, 2006Date of Patent: November 22, 2011Assignees: Novartis AGInventors: Stefan Oscarson, Peter Teodorovic, Paolo Costantino
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Publication number: 20100074938Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.Type: ApplicationFiled: September 15, 2009Publication date: March 25, 2010Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
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Publication number: 20090304734Abstract: An oligosaccharide useful for a Meningitidis A vaccine contains a first mannose unit having a spacer in the alpha configuration at C-1, which spacer is capable of conjugating to a protein, and which is connected to a second mannose unit through a 1,6-linkage which connects C-6 of the first unit to C-1 of the second unit, wherein the 1,6-linkage comprises a phosphonate. Related methods of making such compounds, analogous compounds, or intermediates thereof are also disclosed.Type: ApplicationFiled: May 8, 2006Publication date: December 10, 2009Inventors: Stefan Oscarson, Peter Teodorovic, Paolo Costantino
