Abstract: In a brewing system with a hot water layered storage tank (2) having a high-temperature area (2?) and a low-temperature area (2?), which has at least one high-temperature water inlet (20, 21, 22), at least one high-temperature water outlet (23), at least a low-temperature water inlet (24) and at least one low-temperature water outlet (25), with a mash vessel (3), a lauter tun (4) or mash filter fluidly connected to the mash vessel (3) via a mash line (34), a wort kettle (5), which has a lauter wort inlet (50), a wort outlet (51) and a vapor condenser (6) with a low-temperature water connection (60) and a high-temperature water connection (61), the lauter wort inlet (50) being connected via a lauter wort line (52).

Abstract: The present disclosure relates to a computer-implemented method for cancer diagnosis, comprising: a) selectively sequencing polymers of a biological sample according to at least one target gene site by translocating the polymers through nanopores of a nanopore sequencing system, including: (i) analyzing an initial nucleotide sequence of a first polymer of the biological sample while the first polymer is translocating through a nanopore of the nanopore sequencing system to determine whether the initial nucleotide sequence corresponds to the at least one target gene site; and (ii) continuing the sequencing of the first polymer to obtain measurement data of the first polymer only if the initial nucleotide sequence of the first polymer corresponds to the at least one target gene site: b) determining, based on the measurement data, a biological state of a nucleotide sequence of the first polymer corresponding to the at least one target gene site; and c) classifying a cancer using a classification algorithm based o

Abstract: A brewing plant, comprising: a hot water storage device, including a high temperature portion and a low temperature portion, at least one high temperature water inlet, at least one high temperature water outlet, at least one low temperature water inlet, at least one low temperature water outlet; a mash container; a lauter tun or a mash filter flow connected with the mash container by a mash conduit; a wort kettle including a lauter wort inlet, a wort outlet, and an exhaust vapor condenser including a low temperature water connection and a high temperature water connection, wherein the lauter wort inlet is directly or indirectly connected through a lauter wort conduit with the lauter tun or the mash filter, wherein the low temperature water outlet of the hot water storage device is connected with the low temperature water connection of the exhaust vapor condenser.

Abstract: The present invention pertains to methods for classifying tumorous diseases based on their specific genomic DNA methylation profile. The invention provides a method that allows for a classification of a tumor sample obtained from a patient by analysing a multitude, preferably genome wide, collection of CpG positions by comparison to a classification rule derived from a set of methylation data acquired from pre-classified tumor species. The invention is in particular useful for classifying brain tumor samples since brain tumors are characterized by a large variety of distinct tumor species which have different prognostic values and require in the clinic a for each species developed treatment regime.