Abstract: Herein is reported a circular fusion polypeptide comprising a first part of a binding domain, a second part of a binding domain and a spacer domain, wherein the spacer domain is a polypeptide and comprises at least 25 amino acid residues, the first part of the binding domain is a polypeptide and is fused via a first linker to the N-terminus of the spacer domain, the second part of the binding domain is a polypeptide and is fused via a second linker to the C-terminus of the spacer domain, the first part of the binding domain and the second part of the binding domain are associated with each other and form a binding site that specifically binds to a target.

Abstract: Device and method for welding a workpiece (2) having a welding torch (3) which can be mechanically coupled by a coupling element (4) to a hose bundle (5) for supplying the welding torch (3) at least with compressed air or with a protective gas, wherein compressed air applied to the coupling element (4) can be diverted by a diverting valve (10) provided in the coupling element (4) for actuating an actuator (7).

Abstract: The invention relates to a wire inlet nozzle (27) for fastening in a coupling (29) of a hose package (21), comprising a wire inlet element (32) and a fastening means (31) for a wire core (26) for guiding a welding wire (9), wherein a main body is formed between the wire inlet element (32) and the fastening means (31) and a cavity (56) is formed in the wire inlet element (32), in which cavity at least one sealing element (57) having an axial opening (59) for guiding the welding wire (9) is arranged. In order to prevent an escape of the protective gas in the wire inlet nozzle (27) in a direction opposite to the main conveying direction of the welding wire (9), the main body forms a first part (54) of the wire inlet element (32), and a second part (55) of the wire inlet element (32) can be detachably connected to the first part (54), and the main body is designed as a separating plane for independently fastening the wire core (26) and the sealing element (57).

Abstract: Device and method for welding a workpiece (2) having a welding torch (3) which can be mechanically coupled by a coupling element (4) to a hose bundle (5) for supplying the welding torch (3) at least with compressed air or with a protective gas, wherein compressed air applied to the coupling element (4) can be diverted by a diverting valve (10) provided in the coupling element (4) for actuating an actuator (7).

Abstract: The invention relates to a wire inlet nozzle (27) for fastening in a coupling (29) of a hose package (21), comprising a wire inlet element (32) and a fastening means (31) for a wire core (26) for guiding a welding wire (9), wherein a main body is formed between the wire inlet element (32) and the fastening means (31) and a cavity (56) is formed in the wire inlet element (32), in which cavity at least one sealing element (57) having an axial opening (59) for guiding the welding wire (9) is arranged. In order to prevent an escape of the protective gas in the wire inlet nozzle (27) in a direction opposite to the main conveying direction of the welding wire (9), the main body forms a first part (54) of the wire inlet element (32), and a second part (55) of the wire inlet element (32) can be detachably connected to the first part (54), and the main body is designed as a separating plane for independently fastening the wire core (26) and the sealing element (57).