Patents by Inventor Stefan Quint

Stefan Quint has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220246412
    Abstract: A method for checking a validity of a mass axis calibration of a mass spectrometer (MS) of an analyzer system, comprising obtaining a mass axis check sample spanning a predetermined m/z measurement range of the MS and automatically processing the sample, performing multiple full scan mode MS measurements of different types using the MS for the at least two mass axis points to obtain measurement data, wherein the different types include at least a first full scan MS measurement in a positive mode and a second measurement in a negative mode, or at least a first full scan measurement for a first mass filter and a second full scan measurement for a second mass filter; comparing the measurement data for each of the at least two mass axis points with respective reference data and determining if a condition is out of specification based on a result of the comparing steps.
    Type: Application
    Filed: March 4, 2022
    Publication date: August 4, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Florian Schweinberger
  • Publication number: 20220172940
    Abstract: A packaging for a needle-like component of a mass spectrometry (MS) system is provided. The packaging includes a receptacle configured for storing the needle-like component in a secured position inside the receptacle. The packaging further comprises an actuator configured to move the needle-like component from the secured position inside the receptacle to a mounting position in which the needle-like component projects out of the receptacle for mounting the needle-like component to the MS system.
    Type: Application
    Filed: November 2, 2021
    Publication date: June 2, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Florian Schweinberger
  • Publication number: 20220165557
    Abstract: A mass spectrometry (MS) apparatus is provided. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer, and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 26, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Robert Lang, Stefan Quint, Gabriele Punzmann
  • Publication number: 20220128531
    Abstract: A liquid chromatography-mass spectrometry (LC-MS) apparatus including an ionization source coupled to a mass spectrometer and a liquid chromatographic (LC) system coupled to the ionization source. The LC system comprises multiple fluidic streams alternately connectable to the ionization source, thereby assigning a detection time window to each fluidic stream from the multiple fluidic streams when connected to the ionization source. The LC-MS apparatus further comprises a controller configured to carry out steps of monitoring an ionization current of the ionization source for the multiple fluidic streams and identifying differences in flow conditions between the multiple fluidic streams based on the monitored ionization current.
    Type: Application
    Filed: September 20, 2021
    Publication date: April 28, 2022
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Benjamin Tiemann, Stefan Quint, Florian Schweinberger
  • Patent number: 11287402
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: March 29, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Patent number: 11249059
    Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: February 15, 2022
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
  • Publication number: 20210381987
    Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
    Type: Application
    Filed: August 18, 2021
    Publication date: December 9, 2021
    Inventors: Hans-Peter JOSEL, Herbert ANDRES, Michaela WINDFUHR, Oliver LARBOLETTE, Stefan QUINT
  • Patent number: 11125695
    Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 21, 2021
    Inventors: Hans-Peter Josel, Herbert Andres, Michaela Windfuhr, Oliver Larbolette, Stefan Quint
  • Publication number: 20210181166
    Abstract: An analytical system including a mass spectrometer (MS) coupled to liquid chromatography (LC) via an ionization source (IS), and an automated method of maintaining the analytical system in a QC-compliant status are described. The method comprises determining a deviation of the analytical system from a QC-compliant status by determining a deviation of one or more predetermined parameters in an m/z spectrum above one or more predetermined thresholds, triggering an IS and/or MS maintenance procedure upon determining a deviation from the QC-compliant status, determining a return or a failed return to the QC-compliant status during and/or after the IS and/or MS maintenance procedure by determining a return or a failed return respectively of the one or more predetermined parameters in an m/z spectrum below the one or more predetermined thresholds, triggering another IS and/or MS maintenance procedure upon determining a failed return to the QC-compliant status.
    Type: Application
    Filed: December 7, 2020
    Publication date: June 17, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Marian Roetzer, Florian Schweinberger, Benjamin Tiemann, Marius Wagner, Ralf Zimmermann
  • Publication number: 20210116290
    Abstract: An automated method for detecting and/or monitoring a state of a degasser of an analyzer is provided, the degasser including a container configured to be evacuated. The method includes obtaining a time series of values indicative of pressures inside the container. The time series spans a period during which the container is evacuated or pressurized. The method further includes determining a liquid level state of the degasser which is determined by an amount of liquid present in the container based on the time series.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 22, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Dieter Kempken
  • Publication number: 20210063361
    Abstract: An automated method of monitoring a state of an analyzer is provided including a mass spectrometer (MS) with an electrospray ionization (ESI) source coupled to a liquid chromatography (LC) stream, including monitoring an electrospray ionization current of the ESI source and identifying a condition of multiple conditions of the analyzer based on the monitored ionization current of the ESI source, one of the conditions being a presence of a dead volume in a liquid chromatography stream of the analyzer downstream of an LC column of the LC stream.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 4, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Benjamin Tiemann, Florian Schweinberger, Martin Stingl
  • Publication number: 20210063363
    Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.
    Type: Application
    Filed: August 18, 2020
    Publication date: March 4, 2021
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Marc Kaminski, Stefan Quint, Benjamin Tiemann
  • Publication number: 20180364175
    Abstract: The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.
    Type: Application
    Filed: August 24, 2018
    Publication date: December 20, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Hans-Peter Josel, Herbert Andres, Michaela Windfuhr, Oliver Larbolette, Stefan Quint
  • Publication number: 20180348140
    Abstract: Described is an electrochemiluminescence method of detecting an analyte in a liquid sample using a measuring cell having a working electrode for detecting the analyte using an electrochemiluminescence measurement cycle, involving a. carrying out the measurement cycle in a calibration process using a liquid sample without analyte and performing a first electrochemical impedance spectroscopy, EIS, at a given point of the measurement cycle, the first EIS being performed using the working electrode, b. carrying out the measurement cycle in an analysis process using the liquid sample containing the analyte and performing a second EIS at the given point of the measurement cycle, the second EIS being performed using the working electrode, c. comparing the result of the first EIS and the second EIS, providing an indication indicating if the comparison results show a deviation between the first EIS and the second EIS exceed a predefined threshold.
    Type: Application
    Filed: July 25, 2018
    Publication date: December 6, 2018
    Applicant: Roche Diagnostics Operations, Inc.
    Inventors: Stefan Quint, Klaus Bauer-Espindola