Abstract: The present application relates to substituted indazoles, to the use thereof alone or in combinations for treatment and/or prophylaxis of autoimmune disorders, and to the use thereof for production of medicaments for treatment and/or prophylaxis of autoimmune disorders, especially for treatment and/or prophylaxis of arthritides (especially psoriatic arthritis, rheumatoid arthritis, Bekhterev's disease, reactive arthritis, systematic juvenile idiopathic arthritis), systematic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, allergic eczema and chronic-inflammatory bowel disorders (especially Crohn's disease and ulcerative colitis).

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.