Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: A system and method are disclosed for monitoring rides in a vehicle in which a driver of the vehicle picks up a rider at a pickup location and drives the rider to a drop-off destination. The system includes at least one sensor arranged in the vehicle and configured to capture sensor data during the rides, a transceiver configured to communicate with a personal electronic device of a driver of the vehicle, a non-volatile memory configured to store data; and a processor. The system captures sensor data during a ride, receives a ride identifier from the personal electronic device that uniquely identifies the ride, and stores the sensor data captured during the ride with the ride identifier as metadata.

Abstract: A calibration circuit, including: a signal generator circuit configured to generate a modulated analog input signal, which is based on a digital input word that is modulated; an Analog-to-Digital Converter (ADC) configured to convert an analog reference signal to a digital calibration word, wherein the analog reference signal is a low-pass-filtered version of the analog input signal generated by the signal generator circuit; and a feedback circuit configured to output the digital input word by adjusting the digital calibration word depending on a digital feedback signal, which is based on a modulated version of the analog reference signal, wherein the signal generator circuit, the ADC, and the feedback circuit are provided on a same chip.

Abstract: A vehicle steering wheel system is provided. The system includes a steering wheel body with a hub region for attachment to a steering shaft of a vehicle steering system, a steering wheel rim and at least one spoke for attaching the steering wheel rim to the hub region; an electromechanical triggering device for triggering an acoustic output by means of an acoustic warning device of the vehicle, wherein the triggering device has an impact absorber cover and at least one force transducer wherein a force value threshold is predefined for each force transducer, and a wake-up signal is transmitted via the data connection to the evaluation unit if the force value threshold is exceeded by at least one force value, so that the latter changes from the energy-saving mode into the operating mode in which an actuating force value is determined by force value measured by the at least one force transducer.

Abstract: It is provided a vehicle seat arrangement for a motor vehicle, comprising a vehicle seat; an inflatable device which is arranged on the vehicle seat for protecting a vehicle occupant located on the vehicle seat; an inflating means for inflating the inflatable device, wherein the inflatable device has at least one inflatable chamber and is designed and arranged in such a manner that the vehicle occupant receives an impulse by the chamber expanding after the inflating means is triggered. The inflatable device is connected to the vehicle seat via at least two connecting regions of a connecting plane of the vehicle seat in such a manner that, after the triggering of the inflating means, the expansion of the chamber substantially takes place only in a single expansion direction obliquely or perpendicularly to the connecting plane.

Abstract: A vehicle seat arrangement for a motor vehicle is provided. The vehicle seat arrangement comprises a vehicle seat, a pre-crash control unit which generates a control signal in the case of an impending collision of the motor vehicle, at least one pivoting element which is arranged in or on a backrest of the vehicle seat in order to move a vehicle occupant who is situated on the vehicle seat, and an actuator which, upon a control signal of the pre-crash control unit, which control signal indicates an impending collision, acts on a lever arm of the pivoting element in such a way that the latter performs a pivoting movement which leads to at least one region of the torso of the vehicle occupant being moved away from a possible collision region of the vehicle.

Abstract: The present invention relates to the use of water soluble lanthanide compounds as stabilizer in electrolytes for electroless metal deposition, an electrolyte as well as a method for the electroless deposition of metals, particularly layers of nickel, copper, cobalt, boron, silver, palladium or gold, as well as layers of alloys comprising at least one of the aforementioned metals as alloying metal.

Abstract: The invention relates to a cyanide-free electrolyte composition for depositing a silver or silver alloy layer on a substrate as well as a method for depositing silver or silver alloy layers with a cyanide-free electrolyte composition. The electrolyte composition according to the invention comprises at least one silver ion source, a sulfonic acid and/or a sulfonic acid derivative, a wetting agent and a hydantoin. The silver or silver alloy layers deposited from the inventive electrolyte composition by the method according to the invention are dull and ductile.

Abstract: The invention relates to a cyanide-free electrolyte composition for depositing a silver or silver alloy layer on a substrate as well as a method for depositing such layers with the help of said cyanide-free electrolyte composition. The electrolyte composition according to the invention comprises at least one silver ion source, a sulfonic acid and/or a sulfonic acid derivative, a wetting agent and a hydantoin. The silver or silver alloy layers deposited from such an electrolyte composition by means of the method according to the invention are dull and ductile.

Abstract: The invention relates to a cyanide-free electrolyte composition for depositing a silver or silver alloy layer on a substrate as well as a method for depositing such layers with the help of said cyanide-free electrolyte composition. The electrolyte composition according to the invention comprises at least one silver ion source, a sulfonic acid and/or a sulfonic acid derivative, a wetting agent and a hydantoin. The silver or silver alloy layers deposited from such an electrolyte composition by means of the method according to the invention are dull and ductile.

Abstract: A block piece for holding a spectacle lens blank has a basic body with a workpiece mounting face portion against which the workpiece can be blocked with a blocking material, and a clamping portion via which the blocked workpiece can be fixed in a machine/apparatus for processing it. The basic body is made substantially of a material having a defined low water absorption and/or is sealed to at least reduce outgassing of water moisture under vacuum conditions, so that the block piece can be used also in vacuum coating processes. Alternatively or in addition, the clamping portion is constructed to be clamped by forces directed essentially perpendicular to the radial direction to cancel out each other and not deform the basic body, and/or the workpiece mounting face portion is provided with a predetermined amount of prism.

Abstract: A cyanide-free electrolyte composition for the galvanic deposition of a copper layer on substrate surfaces and a method for the deposition of such layers. The electrolyte composition comprises at least copper(II) ions, a hydantoin and/or hydantoin derivative, a di- and/or tricarboxylic acid or salts thereof, and a metalate of an element of the group consisting of molybdenum, tungsten and vanadium and/or a cerium compound.

Abstract: A fitting for changing liquid paths, in particular for systems with a pressure exchanger, is provided. The pressure exchanger has pipes having alternating flow direction. The casing of the fitting includes an inlet piece, an outlet piece and a connection piece and at least one shut-off member connected to an actuator. The actuator is connected to a control device that controls the actuator to control a liquid flow between the inlet piece and the connection piece, or between the connection piece and the outlet piece. An actuator displaces a respective shut-off member arranged in each of the inlet piece and the outlet piece, with the shut-off members being axially displaceable to vary the size of flow openings that permit flow between the inlet piece and the connection piece or between the connection piece and the outlet piece.

Abstract: The invention as described in the following relates to an apparatus for the electrochemical deposition of a metal on a substrate, which apparatus is capable of refreshing an electrolyte used for the deposition in a continuous way. Furthermore, the invention as described relates to a method of refreshing an electrolyte for the electrochemical deposition of a metal on a substrate.

Abstract: The present invention relates to methods for determining the efficiency of an ion channel ligand comprising (a) contacting a cell expressing the ion channel with (i) plasma of an animal and (ii) the ion channel ligand and (b) determining the effect of the ion channel ligand on the cell.

Abstract: The present invention relates to methods for determining the in vivo efficiency of a sodium-proton-exchanger (NHE) ion channel ligand comprising the steps of: (a) contacting a cell expressing a sodium-proton-exchanger (NHE) ion channel in vitro with either (i) plasma of an animal and the ion channel ligand or (ii)) the plasma of an animal which has been administered the ion channel ligand; (b) determining the effect of the ion channel ligand on the cell; c) determining ion channel ligand availability by comparing the ligand concentration in the plasma to the concentration of ligand administered; and d) correlating the effect of the ion channel ligand on the cell with the ligand availability to determine the in vivo efficiency of the ligand.

Abstract: A membrane module for an immersed operation has a fiber bundle of hollow fiber membranes which are cast into a headpiece and in immersed operation are surrounded by a liquid to be filtered. The module has a permeate collection chamber connected to the headpiece with an outlet for permeate draining from the interior of the hollow fiber membranes, and a gas supply having a pipe guided by the headpiece. The pipe terminates in the interior of the fiber bundle and has a gas outlet for a gaseous medium, which after the transfer from the pipe to the liquid to be filtered rises as bubbles between the hollow fiber membranes. The fiber bundle is divided into sections and free spaces remain between the sections which extend from the pipe to the outer circumference of the headpiece and promote an inflow of the liquid into a foot area adjoining the headpiece.

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: An airbag device for a vehicle passenger-protecting system. According to one variant, the airbag device comprises a first airbag segment, which has at least two material blanks and a second airbag segment which has at least two material blanks, wherein the material blanks of the first airbag segment and the material blanks of the second airbag segment are connected to one another at the respective circumferential edge in a gas-tight manner. The first airbag segment has a first transitional section and the second airbag segment has a second transitional section, wherein the transitional sections form a transitional region in which the two airbag segments are connected to one another in a gas-tight manner. An opening can be formed in each of the two transitional sections.

Abstract: In one aspect, a device is provided. The device comprises at least one detection unit which generates an output signal in accordance with a status of a transmission path. Accordingly, switching of a telephone between two transmission paths is controlled in a simple manner in accordance with the output signal.