Abstract: A fitting for changing liquid paths, in particular for systems with a pressure exchanger, is provided. The pressure exchanger has pipes having alternating flow direction. The casing of the fitting includes an inlet piece, an outlet piece and a connection piece and at least one shut-off member connected to an actuator. The actuator is connected to a control device that controls the actuator to control a liquid flow between the inlet piece and the connection piece, or between the connection piece and the outlet piece. An actuator displaces a respective shut-off member arranged in each of the inlet piece and the outlet piece, with the shut-off members being axially displaceable to vary the size of flow openings that permit flow between the inlet piece and the connection piece or between the connection piece and the outlet piece.

Abstract: The present invention relates to methods for determining the efficiency of an ion channel ligand comprising (a) contacting a cell expressing the ion channel with (i) plasma of an animal and (ii) the ion channel ligand and (b) determining the effect of the ion channel ligand on the cell.

Abstract: The present invention relates to methods for determining the in vivo efficiency of a sodium-proton-exchanger (NHE) ion channel ligand comprising the steps of: (a) contacting a cell expressing a sodium-proton-exchanger (NHE) ion channel in vitro with either (i) plasma of an animal and the ion channel ligand or (ii)) the plasma of an animal which has been administered the ion channel ligand; (b) determining the effect of the ion channel ligand on the cell; c) determining ion channel ligand availability by comparing the ligand concentration in the plasma to the concentration of ligand administered; and d) correlating the effect of the ion channel ligand on the cell with the ligand availability to determine the in vivo efficiency of the ligand.

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: In one aspect, a device is provided. The device comprises at least one detection unit which generates an output signal in accordance with a status of a transmission path. Accordingly, switching of a telephone between two transmission paths is controlled in a simple manner in accordance with the output signal.

Abstract: A device for gassing a liquid, particularly for membrane facilities used in immersion operation, has a gas supply channel and at least one gas lance from which a gas flow exits in gassing operation. The gas lance is connected to the gas supply channel via at least one connection channel including a first mouth area on the side of the gas lance and a second mouth area on the side of the gas supply channel and generating as a throttle a flow pressure loss of the gas flow entering the gas lance. Below the first mouth area an extension section is provided, which adjoins the gas lance and has an opening below the first mouth area.

Abstract: The present invention relates to methods for determining the efficiency of an ion channel ligand comprising (a) contacting a cell expressing the ion channel with (i) plasma of an animal and (ii) the ion channel ligand and (b) determining the effect of the ion channel ligand on the cell.

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: A control element includes a switching element, an operating element for operating the switching element, a printed circuit board, and an electrically conductive sensor element of a capacitive proximity sensor integrated in the operating element. The electrically conductive sensor element is designed to be electrically conductively connected to the printed circuit board.

Abstract: The present invention relates to a device for gassing a liquid (1), particularly for membrane facilities used in immersion operation, having a gas supply channel (2) and at least one gas lance (3) from which a gas flow exits in gassing operation. According to the present invention the gas lance (3) is connected to the gas supply channel (2) by means of at least one connection channel (5) comprising a first mouth area (8) on the side of the gas lance (3) and a second mouth area (8?) on the side of the gas supply channel (2) and generating as a throttle a flow pressure loss of the gas flow entering the gas lance (3). Below the first mouth area (8) an extension section (6) is provided, which adjoins the gas lance (3) and has an opening (7) below the first mouth area (8).

Abstract: The invention describes the use of PPAR agonists of the formulae (I) or (II) for the treatment of congestive heart failure (CHF).

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: An operating element, in particular for a motor vehicle component, includes an actuating element that is movably supported in a carrier element and acts, in particular, on a switch element. To detect an approach of a user to the operating element, but at the same time to prevent a misdetection by a movable component, an electrically conductive sensor element of a capacitive proximity sensor and at least one shielding element are arranged in an interior space of the actuating element, the sensor element and the shielding element being connected to a printed circuit board in an electrically conducting fashion.

Abstract: The present invention is directed to a method identifying a risk for a thrombogenic disorder, to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism.

Abstract: In one aspect, a device is provided. The device comprises at least one detection unit which generates an output signal in accordance with a status of a transmission path. Accordingly, switching of a telephone between two transmission paths is controlled in a simple manner in accordance with the output signal.

Abstract: According to the invention, connection information (vcxIndex) representing each connection (AE1 . . . n) of the at least one communication device (KE1 . . . n) to a multiplexer device (MUX) is stored in the multiplexer device, the connection information (vcxIndex) is allocated to the at least one communication network specific address (IP) of the at least one communication device (KE1 . . . n) connected to the connector (AE1 . . . n). A message (ARP-REQUEST) sent to the multiplexer device (MUX) is detected and at least one target address (ZA) contained therein is compared with the stored communication network specific addresses (IP). On determination of an at least partial match of the compared pieces of information (IP, ZA) the message (ARP-REQUEST) or information or initiating the communication relationship device is forwarded to the at least one connector (AE1 . . . n) represented by the allocated connector information (vcxIndex).

Abstract: A measuring method for measuring currents with a large dynamic range by means of a magnetic measuring module has the steps of switching into a high-current mode when a current threshold value is exceeded, and switching into a low-current mode otherwise, wherein the low-current mode has the following steps:—Feeding a first current pulse to a compensation coil, which drives a magnetic core in a first direction until magnetic saturation occurs,—measuring a first primary current value I1 after the current pulse is disconnected,—feeding a second current pulse to the compensation coil, which drives the magnetic core in a counter second direction until magnetic saturation occurs,—measuring a second primary current value I2 after the second current pulse is disconnected,—determining the corrected primary current value subsequently as an average value I=(I1+I2)/2 from the first and the second primary current values.

Abstract: The invention describes the use of PPAR agonists of the formulae (I) or (II) for the treatment of congestive heart failure (CHF).

Abstract: An operating element, in particular for a motor vehicle component, includes an actuating element that is movably supported in a carrier element and acts, in particular, on a switch element. To detect an approach of a user to the operating element, but at the same time to prevent a misdetection by a movable component, an electrically conductive sensor element of a capacitive proximity sensor and at least one shielding element are arranged in an interior space of the actuating element, the sensor element and the shielding element being connected to a printed circuit board in an electrically conducting fashion.