Abstract: The present application relates to chemical compounds of Formula (A): and pharmaceutically acceptable salts thereof, wherein X, R1, and R2 are as defined herein. The chemical compounds of Formula (A) inhibit IRAK4 and consequently have potential utility in medicine.

Abstract: The present application relates to chemical compounds of Formula (I), and pharmaceutically acceptable salts thereof, that inhibit IRAK4 and consequently have potential utility in medicine.

Abstract: Composition comprising a heterophasic propylene copolymer with low melt flow rate and rather low amount of xylene cold solubles and a recycled polymer composition being rich in polypropylene.

Abstract: Injection molded article comprising at least 60 wt.-% of a heterophasic propylene copolymer, said polymer comprises a matrix being a polypropylene, said polypropylene comprises at least three polypropylene fractions, the three polypropylene fractions differ from each other by the melt flow rate and at least one of the three polypropylene fractions has a melt flow rate in the range of 1.0 to 20.0 g/10 min, and an elastomeric propylene copolymer dispersed in said matrix, wherein said heterophasic propylene copolymer has a melt flow rate of equal or more than 20.0 g/10 min and the amorphous phase of the xylene cold soluble fraction of the heterophasic propylene copolymer has an intrinsic viscosity of equal or higher than 2.0 dl/g.

Abstract: Fiber reinforced composition comprising a heterophasic propylene copolymer, a propylene homopolymer and/or a propylene copolymer, and fibers, wherein the propylene copolymer comprises not more than 2.0 wt.-% C2 to C10 ?-olefins other than propylene, the propylene homopolymer and the propylene copolymer have a melt flow rate MFR2 (230° C.) of at least 500 g/10 min, and the composition has a melt flow rate MFR2 (230° C.) of at least 10 g/10 min.

Abstract: The invention pertains to a polypropylene composition consisting of: 55 to 79 wt % base polymer mix; 18 to 44.5 wt % talc; and 0.5 to 3 wt % additives based on the total weight of the polypropylene composition, the base polymer mix containing a XCU fraction and a XCS fraction and the XCU fraction being present in an amount of 91 to 98 wt % and the XCS fraction being present in an amount of 2 to 9 wt %; the base polymer mix containing a comonomer content of less than 5 wt % with respect to the base polymer mix; the talc having a d50 median particle size of 1.0 to 3.0 ?m when measured according to ISO 13317-3 15 using a Sedigraph; and the composition having a MFR (230° C./2.16 kg; ISO 1133) of 1 to 10 g/10 min. a process for the production of such a polypropylene composition and article comprising said polypropylene composition.

Abstract: Injection molded article comprising at least 60 wt.-% of a heterophasic propylene copolymer, said polymer comprises a matrix being a polypropylene, said polypropylene comprises at least three polypropylene fractions, the three polypropylene fractions differ from each other by the melt flow rate and at least one of the three polypropylene fractions has a melt flow rate in the range of 1.0 to 20.0 g/10 min, and an elastomeric propylene copolymer dispersed in said matrix, wherein said heterophasic propylene copolymer has a melt flow rate of equal or more than 20.0 g/10 min and the amorphous phase of the xylene cold soluble fraction of the heterophasic propylene copolymer has an intrinsic viscosity of equal or higher than 2.0 dl/g.

Abstract: The invention pertains to a polypropylene composition consisting of: 55 to 79 wt % base polymer mix; 18 to 44.5 wt % talc; and 0.5 to 3 wt % additives based on the total weight of the polypropylene composition, the base polymer mix containing a XCU fraction and a XCS fraction and the XCU fraction being present in an amount of 91 to 98 wt % and the XCS fraction being present in an amount of 2 to 9 wt %; the base polymer mix containing a comonomer content of less than 5 wt % with respect to the base polymer mix; the talc having a d50 median particle size of 1.0 to 3.0 ?m when measured according to ISO 13317-3 15 using a Sedigraph; and the composition having a MFR (230° C./2.16 kg; ISO 1133) of 1 to 10 g/10 min a process for the production of such a polypropylene composition and article comprising said polypropylene composition.

Abstract: The invention relates to novel propylene polymers with improved properties especially with improved stiffness and impact strength comprising propylene homopolymers or propylene block copolymers with 90.0 to 99.9 wt % propylene and 0.1 to 10 wt % ?-olefins with 2 or 4 to 18 carbon atoms, or mixtures thereof, wherein the propylene homopolymers or propylene block copolymers are ?-nucleated propylene polymers, whereby the ?-nucleated propylene homopolymers have an Ir??0.98 and the values for tensile modulus and Charpy impact strength as specified herein. The ?-nucleated propylene block copolymers are polymers having an IR? of the propylene homopolymer block of ?0.98 and the values for tensile modulus and Charpy impact strength as also specified herein. The propylene polymers with an improved property spectrum are suitable for producing molded parts in a pipe system, such as pipes and fittings, inspection chambers, pipe ducting systems, extrusion or compression molded sheets and the like.

Abstract: The invention relates to novel propylene polymers with improved properties especially with improved stiffness and impact strength comprising propylene homopolymers or propylene block copolymers with 90.0 to 99.9 wt % propylene and 0.1 to 10 wt % ?-olefins with 2 or 4 to 18 carbon atoms, or mixtures thereof, wherein the propylene homopolymers or propylene block copolymers are ?-nucleated propylene polymers, whereby the ?-nucleated propylene homopolymers have an Ir??0.98 and the values for tensile modulus and Charpy impact strength as specified herein. The ?-nucleated propylene block copolymers are polymers having an IR? of the propylene homopolymer block of ?0.98 and the values for tensile modulus and Charpy impact strength as also specified herein. The propylene polymers with an improved property spectrum are suitable for producing molded parts in a pipe system, such as pipes and fittings, inspection chambers, pipe ducting systems, extrusion or compression molded sheets and the like.

Abstract: Polypropylene composition comprising a) an isotactic polypropylene (iPP) produced in the presence of a single-site catalyst and said isotactic polypropylene (iPP) has a mean isotactic block length between two structural chain defects, as a statistical average, greater than 70, and b) an atactic polypropylene (aPP) with an absorbance ratio of the absorption band at 998 cm?1 to the absorption band at 973 cm?1 [A998/A973] below 0.80 wherein the weight ratio of said atactic polypropylene to the sum of said atactic polypropylene and said isotactic polypropylene (aPP/(aPP+iPP)) is at least 0.50 wt.-%.

Abstract: Fiber reinforced composition comprising a heterophasic propylene copolymer, a propylene homopolymer and/or a propylene copolymer, and fibers, wherein the propylene copolymer comprises not more than 2.0 wt.-% C2 to C10 ?-olefins other than propylene, the propylene homopolymer and the propylene copolymer have a melt flow rate MFR2 (230° C.) of at least 500 g/10 min, and the composition has a melt flow rate MFR2 (230° C.) of at least 10 g/10 min.

Abstract: The invention relates to novel propylene polymers with improved properties especially with improved stiffness and impact strength comprising propylene homopolymers or propylene block copolymers with 90.0 to 99.9 wt % propylene and 0.1 to 10 wt % ?-olefins with 2 or 4 to 18 carbon atoms, or mixtures thereof, wherein the propylene homopolymers or propylene block copolymers are ?-nucleated propylene polymers, whereby the ?-nucleated propylene homopolymers have an IR??0.98, a tensile modulus ?1500 MPa at +23° C. and a Charpy impact strength, ?3 kJ/m2 at ?20° C. using notched test specimens, and the ?-nucleated propylene block copolymers are polymers having an IR? of the propylene homopolymer block of ?0.98, a tensile modulus ?1100 Mpa at +23° C. and a Charpy impact strength of ?6 kJ/m2 at ?20° C. using notched test specimens.

Abstract: Polypropylene composition comprising a) an isotactic polypropylene (iPP) produced in the presence of a single-site catalyst and said isotactic polypropylene (iPP) has a mean isotactic block length between two structural chain defects, as a statistical average, greater than 70, and b) an atactic polypropylene (aPP) with an absorbance ratio of the absorption band at 998 cm?1 to the absorption band at 973 cm?1 [A998/A973] below 0.80 wherein the weight ratio of said atactic polypropylene to the sum of said atactic polypropylene and said isotactic polypropylene (aPP/(aPP+iPP)) is at least 0.50 wt.-%.

Abstract: Inner liners of foam insulated refrigerators and freezers are made of mineral filled bimodal polyethylene.

Abstract: Inner liners of foam insulated refrigerators and freezers are made of mineral filled bimodal polyethylene.

Abstract: The invention relates to novel propylene polymers with improved properties especially with improved stiffness and impact strength comprising propylene homopolymers or propylene block copolymers with 90.0 to 99.9 wt % propylene and 0.1 to 10 wt % &agr;-olefins with 2 or 4 to 18 carbon atoms, or mixtures thereof, wherein the propylene homopolymers or propylene block copolymers are &bgr;-nucleated propylene polymers, whereby the &bgr;-nucleated propylene homopolymers have an IR&tgr;≧0.98, a tensile modulus ≧1500 MPa at +23° C. and a Charpy impact strength, ≧3 kJ/m2 at −20° C. using notched test specimens, and the &bgr;-nucleated propylene block copolymers are polymers having an IR&tgr; of the propylene homopolymer block of ≧0.98, a tensile modulus ≧1100 Mpa at +23° C. and a Charpy impact strength of ≧6 kJ/m2 at −20° C. using notched test specimens.

Abstract: The invention relates to a high resistance polypropylene tube especially with a high modulus of elasticity in extension, high impact strength, annular rigidity and resistance towards knocks. The inventive tube is made of polypropylene and has a modulus of elasticity in extension of 1300-2300 N/mm2 and an impact strength of 60-110 kJ/m2. The inventive tube is produced by extrusion of a plastic moulding material consisting of two constituents A and B of composition A) 80-98 mass parts of an isotactic polypropylene homopolymer as a coherent matrix constituent with a decade regularity of >95% and B) 2-20 mass parts of a copolymer, consisting of 50-70 mass parts of propylene and 30-50 mass parts of ethylene and/or other C4-C8-&agr;-olefins as a dispersedly distributed elastomer component. The intrinsic viscosity ratio of both components B/A is 0.9-1.5 and the melt flow index of the moulding material is 0.15-0.8 g/10 min.