Patents by Inventor Stefan Schiller
Stefan Schiller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11478459Abstract: The present invention relates to a solid pharmaceutical preparation of 3-Fluoro-4-[7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-benzonitrile, a method of making same, and medical uses thereof.Type: GrantFiled: August 8, 2018Date of Patent: October 25, 2022Assignee: Merck Patent GmbHInventors: Simon Geissler, Stefan Schiller, Meike Harms, Holger Kubas, Markus Weigandt, Michael Lange
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Publication number: 20220184223Abstract: The present invention relates to a process for the preparation of a conjugate, comprising a biological molecule, an enzymatic tag, a hydrophilic spacer, a linker and a lipophilic moiety using enzymatic coupling.Type: ApplicationFiled: March 10, 2020Publication date: June 16, 2022Applicant: MERCK PATENT GMBHInventors: Steffen WOELL, Stefan SCHILLER, Simon GEISSLER
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Publication number: 20220110830Abstract: The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Applicant: Merck Patent GmbHInventors: Stefan SCHILLER, Andrea HANEFELD, Gerhard JONSCHKER
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Publication number: 20220040917Abstract: The present invention is directed to a process for the preparation of a coated solid pharmaceutical dosage form using 3D printing technology.Type: ApplicationFiled: September 12, 2019Publication date: February 10, 2022Applicant: MERCK PATENT GMBHInventors: Malte BOGDAHN, Stefan SCHILLER, Andrea HANEFELD, Simon GEISSLER
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Patent number: 11229577Abstract: The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.Type: GrantFiled: September 8, 2017Date of Patent: January 25, 2022Assignee: Merck Patent GmbHInventors: Stefan Schiller, Andrea Hanefeld, Gerhard Jonschker
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Publication number: 20200237733Abstract: The present invention relates to a solid pharmaceutical preparation of 3-Fluoro-4-[7-methoxy-3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl]-benzonitrile, a method of making same, and medical uses thereof.Type: ApplicationFiled: August 8, 2018Publication date: July 30, 2020Applicant: Merck Patent GmbHInventors: Simon GEISSLER, Stefan SCHILLER, Meike HARMS, Holger KUBAS, Markus WEIGANDT, Michael LANGE
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Patent number: 10561622Abstract: The present invention is directed to a process for the preparation of enteric microparticles comprising nanoparticles, wherein the nanoparticles comprise a matrix and an active ingredient. The microparticles obtained by such process are usable various multiparticulate pharmaceutical formulations such as extemporaneous dosage forms (powder for reconstitution).Type: GrantFiled: October 15, 2015Date of Patent: February 18, 2020Assignee: Merck Patent GmbHInventors: Andrea Hanefeld, Markus Weigandt, Stefan Schiller, Marc Schneider, Michael C. Lehr
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Patent number: 10428137Abstract: The present invention relates to a method for assembling (monomeric or oligomeric) proteins and peptide structures to multimeric protein or peptide structures. The present invention also provides a method for preparing peptide based polymers by crosslinking such multimeric proteins or peptides obtainable according to the inventive method and their use as polymers, for amphiphilic applications, as protein based detergents, for forming artificial organelles, etc. Disclosed are furthermore novel protein or peptide structures, nucleic acids encoding same and cloning and expression vectors suitable for carrying out the inventive method for assembling multimeric proteins or peptides.Type: GrantFiled: May 28, 2013Date of Patent: October 1, 2019Assignee: ALBERT-LUDWIGS-UNIVERSITAT FREIBURGInventors: Stefan Schiller, Matthias Huber
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Publication number: 20190192383Abstract: The present invention relates to a process for the preparation of a solid pharmaceutical administration form using a 3D printing process as well. The process is a printing process that allows the production of solid pharmaceutical administration forms in a flexible manner and in conformity with the high quality standards required for the production of pharmaceuticals.Type: ApplicationFiled: September 8, 2017Publication date: June 27, 2019Applicant: Merck Patent GmbHInventors: Stefan SCHILLER, Andrea HANEFELD, Gerhard JONSCHKER
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Publication number: 20170312229Abstract: The present invention is directed to a process for the preparation of enteric microparticles comprising nanoparticles, wherein the nanoparticles comprise a matrix and an active ingredient. The microparticles obtained by such process are usable various multiparticulate pharmaceutical formulations such as extemporaneous dosage forms (powder for reconstitution).Type: ApplicationFiled: October 15, 2015Publication date: November 2, 2017Applicant: Merck Patent GmbHInventors: Andrea HANEFELD, Markus WEIGANDT, Stefan SCHILLER, Marc SCHNEIDER, Michael C. LEHR
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Publication number: 20150126452Abstract: The present invention relates to a method for assembling (monomeric or oligomeric) proteins and peptide structures to multimeric protein or peptide structures. The present invention also provides a method for preparing peptide based polymers by crosslinking such multimeric proteins or peptides obtainable according to the inventive method and their use as polymers, for amphiphilic applications, as protein based detergents, for forming artificial organelles, etc. Disclosed are furthermore novel protein or peptide structures, nucleic acids encoding same and cloning and expression vectors suitable for carrying out the inventive method for assembling multimeric proteins or peptides.Type: ApplicationFiled: May 28, 2013Publication date: May 7, 2015Inventors: Stefan Schiller, Matthias Huber
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Publication number: 20110076718Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids that comprise a 1,2 aminothiol group into polypeptides. The invention provides translation systems in which polypeptides comprising unnatural amino acids that comprise a 1,2 aminothiol group can be produced. The invention also provides methods for producing polypeptides containing unnatural amino acids that comprise a 1,2 aminothiol group. Also provided by the invention are compositions comprising orthogonal aminoacyl-tRNA synthetases that preferentially aminoacylate a cognate orthogonal tRNA with unnatural amino acids that comprise a 1,2 aminothiol group. The invention provides methods for the synthesis of the unnatural amino acid 2-amino-3-(4-(2-amino-3-mercaptopropan-amido)phenyl)-propanoic acid.Type: ApplicationFiled: February 27, 2009Publication date: March 31, 2011Inventors: Simon Ficht, Michael Jahnz, Jan Grunewald, Stefan Schiller, Peter G. Schultz
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Patent number: 7518010Abstract: The invention concerns lipids functionalized with a terminal C?C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.Type: GrantFiled: June 7, 2006Date of Patent: April 14, 2009Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.Inventors: Vladimir Atanasov, Ingo Köper, Wolfgang Knoll, Stefan Schiller
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Publication number: 20060292637Abstract: The invention concerns lipids functionalized with a terminal C?C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on substrates, in particular on silicon oxide substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. These membrane systems can be directly anchored on silicon microelectronic devices. After the optional incorporation of functional molecules such as membrane-associated proteins such systems can used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.Type: ApplicationFiled: June 7, 2006Publication date: December 28, 2006Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Vladimir Atanasov, Ingo Koper, Wolfgang Knoll, Stefan Schiller