Abstract: The present disclosure provides a measurement application device comprising at least one signal acquisition interface configured to acquire an analog input signal and output a digital input signal, a first decimator for each signal acquisition interface, each one of the first decimators being configured to reduce the number of samples of the respective digital input signal and output a first decimated digital input signal, at least one second decimator for each signal acquisition interface, each one of the second decimators being configured to reduce the number of samples of the respective digital input signal and output a second decimated digital input signal, and at least one decoder for each one of the second decimators, each one of the decoders being configured to decode the respective second decimated digital input signal according to a respective protocol and provide a respective decoded input signal.

Abstract: The present invention relates to nicotinamide (niacinamide) or suitable precursors or metabolites thereof and compositions thereof for use for reducing the time to resolution of one or more symptoms in patients with COVID-19 or in patients with other viral infections.

Abstract: The invention provides a polypeptide dimer comprising two gp130-Fc fusion peptides for use in the treatment of ASCVD in human patients, preferably of high-risk ASCVD in human patients, more preferably of very-high-risk ASCVD in human patients.

Abstract: The present invention relates to microcapsules comprising a core containing vitamin B3, which are characterised by a coating layer system comprising two layers of shellac and a pH-modulating substance provided between the two layers of shellac.

Abstract: The present invention relates to microcapsules comprising a core containing an active substance, which are characterised by a coating layer system comprising two layers of shellac and a pH-modulating substance provided between the two layers of shellac.

Abstract: A method and an apparatus control a printing press having a plurality of printing units, a plurality of cylinders which are coupled mechanically to one another and a control computer for controlling at least one drive motor which drives the mechanically coupled cylinders. A torsion model is stored in the machine computer for describing the torsion state of the cylinders in the printing press which are rotatably coupled mechanically to one another, as a function of at least one measurable operating parameter or at least one variable of the printing press which is known to the machine computer. A control of the printing press is performed by the control computer on the basis of the values which are calculated by the torsion model.

Abstract: A method and a device for determining color register and lateral register deviations on printing material during production in multi-color printing presses, include a computing unit which takes into consideration the influence of ghosting effects when measuring the deviations on the printing material. The ghosting effects of at least one preceding and/or one succeeding printed image are recursively taken into consideration in the computing unit, when measuring on the printing material.

Abstract: A method of compensating for vibration-induced circumferential-register errors in a sheet-fed printing press includes compensating for at least one vibration-induced deviation of an actual angular position of a cylinder from a nominal angular position by adjusting the circumferential register of at least one printing unit, in particular of the cylinder. For this purpose, the current vibration state of the sheet-fed printing press is determined, the effect of the determined vibrations of an integer order on a position of color excerpts on a sheet of printing material is calculated, and the compensating circumferential-register adjustment required in accordance with the result of the calculation is carried out. A sheet-fed printing press for carrying out the method, is also provided.

Abstract: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.

Abstract: In a method for compensating an oscillation which has a frequency spectrum with a number of discrete frequency components in a printing press, at least one counter torque is introduced into the printing press in order to compensate for at least one discrete frequency component of the oscillation. A first group of one or more frequency components are compensated for by introducing one or more previously determined counter torques, and a second group of one or more frequency components is compensated for by introducing specific counter torques as a function of a measurement, carried out during the operation of the printing press, of at least one signal which contains at least the one or the plurality of frequency components.

Abstract: A method and a device for determining color register and lateral register deviations on printing material during production in multi-color printing presses, include a computing unit which takes into consideration the influence of ghosting effects when measuring the deviations on the printing material. The ghosting effects of at least one preceding and/or one succeeding printed image are recursively taken into consideration in the computing unit, when measuring on the printing material.

Abstract: The invention relates to an exonuclease 1 (EXO1) promoter polymorphism associated with exceptional life expectancy in humans. More specifically, the invention relates to the promoter region of EXO1 where the gene has been found to be mutated. Moreover, the invention relates to a gene regulation mechanism involving transcription factor E47 as a transcriptional repressor of EXO1.

Abstract: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.

Abstract: The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.

Abstract: The invention relates to an optical data carrier which combines a CD layer with at least one further format, such as a DVD layer for example. If a hybrid data carrier of this kind is to be produced in a thickness of less than 1.7 mm, and preferably in a thickness of 1.5 mm or less, then, seen from the surface which is to be read from, the CD layer will normally be situated at a depth of considerably less than 1.1 mm, and the CD substrate therefore has to be thinned down. The quality of the reading signals obtained is increased by increasing the length of the optically readable structures of the CD layer in comparison with the values which are usual in this case. Because of the difficulties which certain CD players have in focussing when the substrates are thin, the refractive index of the disc material used is reduced from the figure for polycarbonate, at least in the case of the CD substrate, the recommended range being between 1.40 and 1.55.

Abstract: The present invention relates to the ATG16l1 gene and genetic variants associated with Crohn's disease. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and/or their response to a particular drug or drugs.

Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.

Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.

Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.

Abstract: A method of compensating for vibration-induced circumferential-register errors in a sheet-fed printing press includes compensating for at least one vibration-induced deviation of an actual angular position of a cylinder from a nominal angular position by adjusting the circumferential register of at least one printing unit, in particular of the cylinder. For this purpose, the current vibration state of the sheet-fed printing press is determined, the effect of the determined vibrations of an integer order on a position of color excerpts on a sheet of printing material is calculated, and the compensating circumferential-register adjustment required in accordance with the result of the calculation is carried out. A sheet-fed printing press for carrying out the method, is also provided.