Abstract: A measurement apparatus (10) for interferometrically measuring a shape of a surface (12) of a test object (14) in relation to a reference shape includes a diffractive optical element (30) generating a test wave (32) from measurement radiation (22), whereas a wavefront of the test wave is adapted to a target shape of the surface of the test object and the target shape is configured as a first non-spherical surface, and a reference element (38) with a reference surface (40) having the reference shape, the reference shape being configured as a further non-spherical surface and the reference element including a low thermal expansion material with a mean coefficient of thermal expansion having an absolute value of no more than 200×10?6 K?1 in the temperature range from 5° C. to 35° C.

Abstract: Provided is a package made of a composite material is represented and described, including a package base with two front base corners and with two rear base corners, a package gable with two front gable corners and with two rear gable corners, and a package base body with a front panel, a first side panel, a second side panel and a rear panel. The package base and the package gable are arranged on opposite sides of the package base body. The composite material has a polymer inner layer, a polymer outer layer and a fibrous support layer, which is arranged between the polymer outer layer and the polymer inner layer. In order to enable the manufacture of packages with even more complex geometries without impairing the rigidity of the package, it is proposed to provide a third sleeve fold line, which has a plurality of sections, which each adjoin a side panel and the rear panel, and of which at least one section is curved.

Abstract: A measurement apparatus (10) for interferometrically determining a surface shape of a test object (14). A radiation source provides an input wave (42), a multiply-encoded diffractive optical element (60), which is configured to produce by diffraction from the input wave a test wave (66) that is directed at the test object and has a wavefront in the form of a free-form surface and at least one calibration wave (70), and a capture device (46). The calibration wave has a wavefront with a non-rotationally symmetric shape (68f), wherein cross sections through the wavefront of the calibration wave along cross-sectional surfaces each aligned transversely to one another have a curved shape. The curved shapes in the different cross-sectional surfaces differ in terms of an opening parameter. The capture device (46) captures a calibration interferogram formed by superimposing a reference wave (40) with the calibration wave after interaction with a calibration object (74).

Abstract: A measurement apparatus (1) for measuring a shape of a surface (2) of a test object (3), in particular an optical surface (2) by interferometry, has: an illumination device (4) with an illumination source (5) for generating an illumination wave (6), an interferometer device (7) with a splitting element (8) for splitting the illumination wave into a test wave (9) directed at the surface (2) and into a reference wave (10), and for combining the returning test wave (9), having interacted with the surface to be measured, with the reference wave (10), a registration device (11) for registering and evaluating an interference pattern to determine a deviation of the measured surface shape from a target shape, and a control device (12) configured to split the surface (2) to be measured into a plurality of individual areas (13) to be measured.

Abstract: The invention pertains to a polypeptide comprising a truncated von Willebrand Factor (VWF) and a half-life extending moiety, for use in the treatment of a blood coagulation disorder, said treatment comprising administering the polypeptide to a subject having a blood coagulation disorder and having endogenous Factor VIII (FVIII), wherein the activity level of endogenous FVIII in said subject before treatment with said polypeptide is reduced relative to the activity level of FVIII in normal human plasma (NHP) provided that the activity level of endogenous FVIII in said subject is at least 0.5% of the activity level of endogenous FVIII in normal human plasma (NHP), wherein the polypeptide is capable of binding to endogenous FVIII and wherein the endogenous FVIII level is increased following administration of said polypeptide.

Abstract: A method for calibrating a measuring device (10) for interferometrically determining a shape of an optical surface (12) of an object under test (14). The measuring device includes a module plane (32) for arranging a diffractive optical test module (30) which is configured to generate a test wave (34) that is directed at the optical surface and that has a wavefront at least approximately adapted to a target shape (60) of the optical surface. The method includes: arranging a diffractive optical calibration module (44) in the module plane for generating a calibration wave (80), acquiring a calibration interferogram (88) generated using the calibration wave in a detector plane (43) of the measuring device, and determining a position assignment distribution (46) of points (52) in the module plane to corresponding points (54) in the detector plane from the acquired calibration interferogram.

Abstract: A system comprising a ground drilling device with a control device, the system including an input device functionally coupled to the control device for entering at least one parameter for operating the ground drilling device. The at least one parameter may include a parameter that causes the ground drilling device to start drilling. The input device may be configured as a remote control with a feedback device, which outputs a variable that a user can perceive i) tactilely, ii) visually, and/or iii) auditorily, and that depends on a) the operation of the ground drilling device, b) the operating state of the ground drilling device, and/or c) the signal of a detection device.

Abstract: A system comprising a ground drilling device with a control device, the system including an input device functionally coupled to the control device for entering at least one parameter for operating the ground drilling device. The at least one parameter may include a parameter that causes the ground drilling device to start drilling. The input device may be configured as a remote control with a feedback device, which outputs a variable that a user can perceive i) tactilely, ii) visually, and/or iii) auditorily, and that depends on a) the operation of the ground drilling device, b) the operating state of the ground drilling device, and/or c) the signal of a detection device.

Abstract: Systems and methods for verifying stopped traffic and/or fallen object alarms include an image sensor configured to capture a stream of images of a traffic scene, a stopped object component configured to identify a stopped object in the captured images, define an associated object location in the captured images, and classify the detected object. A background modeling system models at least two background images, a slow background image and a fast background image. A DNN is trained to receive the object information and background images to verify the alarm condition.

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present disclosure relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising essentially the A1 domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing the Factor VIII molecule. The disclosure further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non-intravenous injection.

Abstract: A measurement apparatus for interferometric shape measurement of a test object surface. A test optical unit produces from measurement radiation a test wave for irradiating the surface. A reference element with an optically effective surface interacts with a reference wave also produced from the measurement radiation. An interferogram is produced by superimposing the test wave after interaction with the test object's surface. A holding device holds the reference element and moves the reference element relative to the reference wave in at least two rigid body degrees of freedom so that a peripheral point of the reference element's optically effective surface shifts by at least 0.1% of a diameter of the optically effective surface. The at least two degrees of freedom include a translational degree, directed transversely to a propagation direction of the reference wave and a rotational degree, whose rotational axis aligns substantially parallel to the reference wave's propagation direction.

Abstract: A measurement apparatus (10) for interferometrically determining a surface shape of a test object (14). A radiation source provides an input wave (42), a multiply-encoded diffractive optical element (60), which is configured to produce by diffraction from the input wave a test wave (66) that is directed at the test object and has a wavefront in the form of a free-form surface and at least one calibration wave (70), and a capture device (46). The calibration wave has a wavefront with a non-rotationally symmetric shape (68f), wherein cross sections through the wavefront of the calibration wave along cross-sectional surfaces each aligned transversely to one another have a curved shape. The curved shapes in the different cross-sectional surfaces differ in terms of an opening parameter. The capture device (46) captures a calibration interferogram formed by superimposing a reference wave (40) with the calibration wave after interaction with a calibration object (74).

Abstract: A method for calibrating a measuring device (10) for interferometrically determining a shape of an optical surface (12) of an object under test (14). The measuring device includes a module plane (32) for arranging a diffractive optical test module (30) which is configured to generate a test wave (34) that is directed at the optical surface and that has a wavefront at least approximately adapted to a target shape (60) of the optical surface. The method includes: arranging a diffractive optical calibration module (44) in the module plane for generating a calibration wave (80), acquiring a calibration interferogram (88) generated using the calibration wave in a detector plane (43) of the measuring device, and determining a position assignment distribution (46) of points (52) in the module plane to corresponding points (54) in the detector plane from the acquired calibration interferogram.

Abstract: A mirror having a mirror substrate (12, 32, 52), a reflection layer stack (21, 41, 61) reflecting electromagnetic radiation having an operating wavelength that is incident on the optical effective surface (11, 31, 51), and at least one piezoelectric layer (16, 36, 56), arranged between the substrate and the reflection layer stack and to which an electric field producing a locally variable deformation is applied. A first electrode arrangement (20, 40, 60) situated on the side of the piezoelectric layer faces the reflection layer stack, and a second electrode arrangement (14, 34, 54) is situated on the side of the piezoelectric layer facing the mirror substrate. Optionally, a bracing layer (98) is provided, which limits sinking of the piezoelectric layer (96) into the mirror substrate (92) when an electric field is applied, in comparison with an analogous construction lacking the bracing layer, thereby increasing the piezoelectric layer's effective deflection.

Abstract: A pump device, in particular for a fluid circuit in a motor vehicle, comprising a housing, a drive, a rotor, a stator and a radial bearing, wherein the housing has an inlet, wherein the rotor comprises an impeller wheel, wherein the drive is designed to set the rotor in rotation relative to the stator, wherein the inlet is fluidly connected to the impeller wheel, wherein the rotor has a rotor cavity, wherein a section of the stator projects into the rotor cavity, and wherein the radial bearing is situated in the rotor cavity between the section of the stator and the rotor.

Abstract: Systems and methods according to one or more embodiments are provided for classifying and counting objects that pass through monitored zones in a field of view of an imaging device. An imaging device receives a series of images of a target scene having at least one monitored zone. An image processor extracts a target line of image values from each image, and adds the target line to a first spatio-temporal image. An edge detector and a cluster analysis module analyzes the first spatio-temporal image to identify objects associated with the at least one zone. An object classifier classifies in object and stores tracking information.

Abstract: A compensation optical unit (30) for a measurement system (10) for determining a shape of an optical surface (12) of a test object (14) by interferometry generates a measuring wave (44), directed at the test object, with a wavefront that is at least partly adapted to a target shape of the optical surface from an input wave (18). The unit includes first (32) and second (34) optical elements disposed in a beam path of the input wave. The second optical element is a diffractive optical element configured to split the input wave into the measuring wave and a reference wave (42) following an interaction with the first optical element. At least 20% of a refractive power of the entire compensation optical unit is allotted to the first optical element, and this allotted refractive power has the same sign as the refractive power of the entire compensation optical unit.

Abstract: The invention relates to a modified VWF molecule for use in the treatment of a blood coagulation disorder.

Abstract: Systems and methods for controlling traffic signaling includes a wireless sensor operable to detect and receive wireless signals emitted from a vehicle, an image sensor operable to capture a stream of images of a field of view. A traffic control system is operable to extract geographic positioning information for the vehicle from the wireless signals, track the vehicle's movement using the extracted geographic positioning information, detect and track an object in the stream of images corresponding to the vehicle. The vehicle's geographic movement is further tracked using a pixel location of the object in steam of images and a traffic control action is executed based on the geographic movement to facilitate passage of the at least one vehicle through a monitored traffic control location.