Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a pharmaceutical composition comprising such a compound.

Abstract: A computed radiography system including a stimulating light source such as a laser, a photostimulable glass imaging plate (PGIP) substantially transparent to the stimulating light positioned such that the stimulating light impinges the PGIP perpendicularly thereto producing photostimulated luminescence light (PLL), a light collector having a light reflecting inner surface proximate the PGIP for collecting PLL emitted from the PGIP and having a hole or slot therein for admitting stimulating light into the light collector and onto the PGIP. An optical filter in communication with the light collector for blocking stimulating light waves and passing PLL therethrough. A light detector receives PLL from the optical filter and the light collector, mechanism providing relative movement between the PGIP and the stimulating light source, and mechanism including an analog to digital converter for converting the collected and detected PLL to a diagnostic readout. The system is particularly useful in mammography.

Abstract: A solar cell and a method for producing a solar cell are described, comprising at least one photovoltaic layer region (1) which at least partially absorbs photons (6) incident therein, whose photon energy is greater than a minimum photon energy Emin, and releases electrical charge carriers in the form of electron-hole pairs, which are spatially separable within the photovoltaic layer region (1) and can be tapped via at least two electrodes (2), which are electrically connected to the photovoltaic layer region (1), to implement an electrical voltage, and comprising at least one interaction layer (3 and/or 4), which at least partially overlaps the photovoltaic layer region, in which at least a part of the incident photons (6) are subject to an interaction with emission of photons of higher or lower photon energy than that of the incident photons.

Abstract: A computed radiography system including a stimulating light source such as a laser, a photostimulable glass imaging plate (PGIP) substantially transparent to the stimulating light positioned such that the stimulating light impinges the PGIP perpendicularly thereto producing photostimulated luminescence light (PLL), a light collector having a light reflecting inner surface proximate the PGIP for collecting PLL emitted from the PGIP and having a hole or slot therein for admitting stimulating light into the light collector and onto the PGIP. An optical filter in communication with the light collector for blocking stimulating light waves and passing PLL therethrough. A light detector receives PLL from the optical filter and the light collector, mechanism providing relative movement between the PGIP and the stimulating light source, and mechanism including an analog to digital converter for converting the collected and detected PLL to a diagnostic readout. The system is particularly useful in mammography.

Abstract: A radiation detector having glass emitting photons by scintillation in response to incident neutrons and/or electromagnetic radiation of at least about 1 keV, and a system associated with the glass for detecting the presence of photons emitted by scintillation. The glass ceramic material is a fluoride glass matrix having nanocrystalline particles distributed therein substantially all of which are in a phase that scintillates with average diameters of less than about 100 nm in a fluorozirconate matrix. Various metals are disclosed for the ceramic particles and methods of manufacture are also disclosed.

Abstract: Reagents and a method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.

Abstract: A glass ceramic material for storing energy of X-rays and releasing said energy by photo-stimulation comprising a fluoride glass matrix containing micro-crystalline particles, said particles having an average particle size, d, so that d<2 &mgr;m and said glass ceramic shows in a XRD spectrum a continuous spectrum of said glass matrix and discrete peaks superimposed on said continuous spectrum. Said glass matrix contains preferably zirconium ions and ions selected from the group consisting of alkali ions and alkaline earth ions, at least 5 mole % of the fluoride ions is replaced by bromide and/or chloride ions and at least 0.01 mole % of cations selected from the group consisting of transition metal ions, rare earth metal ions, In+, Ga+, Tl+, and Pb2+ is present.