Patents by Inventor Stefan Seeber

Stefan Seeber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PD1 ANTIBODIES AND METHODS OF USE
    Publication number: 20240294642
    Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.
    Type: Application
    Filed: September 13, 2023
    Publication date: September 5, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Laura CODARRI DEAK, Stefan DENGL, Sebastian FENN, Jens FISCHER, Guy GEORGES, Christian KLEIN, Viktor LEVITSKI, Valeria LIFKE, Oliver PLOETTNER, Stefan SEEBER, Barbara WEISER, Ildiko WUENSCHE, Adrian ZWICK
  • ANTI-TIM3 ANTIBODIES AND METHODS OF USE
    Publication number: 20240270844
    Abstract: The invention provides anti-TIM3 antibodies and methods of using the same.
    Type: Application
    Filed: March 8, 2024
    Publication date: August 15, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Valeria Lifke, Guy Georges, Victor Levitsky, Oliver Ploettner, Stefan Seeber, Barbara Weiser, Ildiko Wuensche, Adrian Zwick
  • TELESCOPE WITH AT LEAST ONE VIEWING CHANNEL
    Publication number: 20240259673
    Abstract: A telescope having at least one viewing channel comprises at least one camera.
    Type: Application
    Filed: September 13, 2023
    Publication date: August 1, 2024
    Inventors: Bernhard ANGERER, Georg BLATNIG, Matthias DAXNER, Mario DOHR, Klaus GRAVOGL, Stefan JÖRER, Thomas SALZBURGER, Marco SEEBER, Eva-Maria SONNWEBER, Sebastian WACHSMUTH
  • TELESCOPE WITH AT LEAST ONE VIEWING CHANNEL
    Publication number: 20240251153
    Abstract: A telescope having at least one viewing channel comprises at least one display visible in the at least one viewing channel, in particular overlayed, particularly preferred reflected, in the at least one viewing channel.
    Type: Application
    Filed: September 13, 2023
    Publication date: July 25, 2024
    Inventors: Bernhard ANGERER, Georg BLATNIG, Matthias DAXNER, Mario DOHR, Klaus GRAVOGL, Stefan JÖRER, Thomas SALZBURGER, Marco SEEBER, Eva-Maria SONNWEBER, Sebastian WACHSMUTH
  • Rapid method for cloning and expression of cognate antibody variable gene segments
    Patent number: 12024548
    Abstract: In the method as reported herein the isolation of nucleic acid segments encoding antibody variable domains and the insertion of the isolated nucleic acid segments in eukaryotic expression plasmids is performed without the intermediate isolation and analysis of clonal intermediate plasmids. Thus, in the method as reported herein the intermediate cloning, isolation and analysis of intermediate plasmids is not required, e.g. by analysis of isolated transformed E. coli cells.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: July 2, 2024
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Simone Dethloff, Erhard Kopetzki, Dominique Ostler, Stefan Seeber, Georg Tiefenthaler
  • Immunoconjugates
    Patent number: 12023368
    Abstract: The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Grant
    Filed: June 30, 2022
    Date of Patent: July 2, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Laura Codarri Deak, Christian Klein, Laura Lauener, Valeria G. Nicolini, Stefan Seeber, Pablo Umana, Inja Waldhauer
  • ANTI-LAG3 ANTIBODIES
    Publication number: 20240002506
    Abstract: The present invention relates to anti-LAG3 antibodies, to methods of producing these molecules and methods of using the same.
    Type: Application
    Filed: June 20, 2023
    Publication date: January 4, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Laura CODARRI DEAK, Stefan C. DENGL, Jens FISCHER, Christian KLEIN, Stefan SEEBER, Patrick Alexander Aaron WEBER, Adrian ZWICK
  • BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES
    Publication number: 20230399391
    Abstract: The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
    Type: Application
    Filed: January 5, 2023
    Publication date: December 14, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Monika Baehner, Ulrich Brinkmann, Guy Georges, Remko Albert Griep, Sabine lmhof-Jung, Anita Kavlie, Hubert Kettenberger, Christian Klein, Joerg Thomas Regula, Wolfgang Schaefer, Juergen Michael Schanzer, Werner Scheuer, Stefan Seeber, Markus Thomas
  • CD40L EXPRESSING MAMMALIAN CELLS AND THEIR USE
    Publication number: 20230399396
    Abstract: Herein is reported a co-cultivation system for co-cultivating a pool of rabbit B-cells or single deposited rabbit B-cells wherein cells CD40L expressing CHO cells are used as feeder in the presence of TL-2 and TL-21.
    Type: Application
    Filed: August 11, 2022
    Publication date: December 14, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Josef Endl, Jens Fischer, Peter Kern, Sonja Offner, Josef Platzer, Stefan Seeber
  • COMPLEMENT FACTOR BASED AFFINITY CHROMATOGRAPHY
    Publication number: 20230331796
    Abstract: Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
    Type: Application
    Filed: June 27, 2022
    Publication date: October 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Alexander KNAUPP, Laurent LARIVIERE, Petra RUEGER, Tilman SCHLOTHAUER, Stefan SEEBER
  • ANTI-TIM3 ANTIBODIES AND METHODS OF USE
    Publication number: 20230279109
    Abstract: The invention provides anti-TIM3 antibodies and methods of using the same.
    Type: Application
    Filed: March 20, 2023
    Publication date: September 7, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Valeria Lifke, Guy Georges, Victor Levitsky, Oliver Ploettner, Stefan Seeber, Barbara Weiser, Ildiko Wuensche, Adrian Zwick
  • ANTI-PD1 ANTIBODIES AND METHODS OF USE
    Publication number: 20230183349
    Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.
    Type: Application
    Filed: March 3, 2023
    Publication date: June 15, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Laura CODARRI DEAK, Stefan DENGL, Sebastian FENN, Jens FISCHER, Guy GEORGES, Christian KLEIN, Viktor LEVITSKI, Valeria LIFKE, Oliver PLOETTNER, Stefan SEEBER, Barbara WEISER, Ildiko WUENSCHE, Adrian ZWICK
  • ANTI-PD1 ANTIBODIES AND METHODS OF USE
    Publication number: 20230143310
    Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.
    Type: Application
    Filed: June 30, 2022
    Publication date: May 11, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: JOERG BENZ, LAURA CODARRI DEAK, STEFAN DENGL, SEBASTIAN FENN, JENS FISCHER, GUY GEORGES, CHRISTIAN KLEIN, VIKTOR LEVITSKI, VALERIA LIFKE, OLIVER PLOETTNER, STEFAN SEEBER, BARBARA WEISER, ILDIKO WUENSCHE, ADRIAN ZWICK
  • Immunoconjugates
    Publication number: 20230134606
    Abstract: The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Application
    Filed: June 30, 2022
    Publication date: May 4, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Laura Codarri Deak, Christian Klein, Laura Lauener, Valeria G. Nicolini, Stefan Seeber, Pablo Umana, Inja Waldhauer
  • METHOD FOR PRODUCING MULTISPECIFIC ANTIBODIES
    Publication number: 20230129340
    Abstract: Herein are provided a method for producing a multispecific antibody comprising the steps of providing a mammalian cell expressing the antibody, transfecting said mammalian cell with an expression vector comprising an expression cassette encoding a polypeptide of the antibody that has a domain crossover, cultivating the transfected cell and recovering the antibody from the cell or the cultivation medium and thereby producing the multispecific antibody.
    Type: Application
    Filed: May 25, 2022
    Publication date: April 27, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Stefan SEEBER, Ulrich GOEPFERT, Andrea OSTERLEHNER, Hubert KETTENBERGER, Wolfgang PAUL
  • Antigen Binding Molecules comprising a TNF family ligand trimer and PD1 binding moiety
    Publication number: 20230123178
    Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules having at least one moiety capable of specific binding to PD1 and a first and a second polypeptide that are linked to each other by a disulfide bond, the first polypeptide having two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and the second polypeptide having a single ectodomain of the same TNF ligand family member or a fragment thereof.
    Type: Application
    Filed: January 28, 2022
    Publication date: April 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Claudia Ferrara Koller, Christina Claus, Christian Klein, Stefan Seeber, Maria Amann, Sandra Grau-Richards, Peter Bruenker, Pablo Umana, Viktor Levitski, Ekkehard Moessner
  • Immunoconjugates
    Publication number: 20230071733
    Abstract: The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Application
    Filed: June 7, 2022
    Publication date: March 9, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Laura Codarri Deak, Christian Klein, Laura Lauener, Stefan Seeber, Pablo Umana, Inja Waldhauer
  • BISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO PD1 AND LAG3
    Publication number: 20220387586
    Abstract: The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.
    Type: Application
    Filed: March 7, 2022
    Publication date: December 8, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Laura Codarri Deak, Jens Fischer, Sabine Imhof-Jung, Christian Klein, Stefan Seeber, Patrick Alexander Aaron Weber
  • ANTI-TIM3 ANTIBODIES AND METHODS OF USE
    Publication number: 20220363755
    Abstract: The invention provides anti-TIM3 antibodies and methods of using the same.
    Type: Application
    Filed: December 20, 2021
    Publication date: November 17, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Valeria Lifke, Guy Georges, Victor Levitsky, Oliver Ploettner, Stefan Seeber, Barbara Weiser, Ildiko Wuensche, Adrian Zwick
  • Complement factor based affinity chromatography
    Patent number: 11440942
    Abstract: Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: September 13, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Alexander Knaupp, Laurent Lariviere, Petra Rueger, Tilman Schlothauer, Stefan Seeber