Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for CD69 and provides a CD69-binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QK X21AFKX25X26LKD. The present disclosure also relates to the use of such a CD69-binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.

Abstract: A bike carrier that retains the wheels of a bike in a tray between pivoting retention arms with ratchets that hold the arms against the tires. In embodiments, a retention arm pivot lock acts on a stay between each wheel retention arm and the tray to which it is attached, wherein the pivot ratchet is configured to allow the wheel retention arm to pivot through a reflex angle to provide inward pivoting of the wheel retention arm and outward pivoting of the wheel retention arm to provide a frame for a ramp to allow the bike to roll onto first and second wheel trays. In embodiments, the carrier comprises a rotational pivot assembly configured to pivot the bike carrying tray assembly among a horizontal position, a first downward position and a second downward position.

Abstract: A preparation vessel, in particular for a food processor, has a vessel wall and a preparation area surrounded by the vessel wall. The vessel wall has a cooling device that contacts the vessel wall in a heat-conducting manner for cooling a preparation item present in the preparation area. The vessel wall in at least a partial area has a double-walled design, with an inner wall bordering the preparation area and an outer wall that is formed separately from the inner wall and spaced apart from the inner wall by a gap, wherein the gap has the cooling device and a phase change material located between the cooling device and the outer wall as viewed in a direction from the preparation area to the outer wall.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid ? (A?) peptides (in the following referred to as A?), comprising the amino acid sequence EX2X3YX5X6NLX9A X11QLCAX16IX18X19X20 ED (SEQ ID NO:632). The present disclosure also relates to the use of such A? peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

Abstract: A line dispensing device includes a housing, a rotatable shaft rotatably supported by the housing and defining a rotational axis, and a line drum disposed about the rotational axis and configured to extend and retract a line from the housing. The line dispensing device also includes a retraction assembly disposed about the rotational axis and configured to generate a retraction force and retract the line from the housing, and a braking assembly disposed about the rotational axis and configured to generate a braking force on the line and during extension of the line from the housing.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid ? (A?) peptides (in the following referred to as A?), comprising the amino acid sequence EX2X3YX5X6NLX9A X11QLCAX16IX18X19X20 ED (SEQ ID NO:632). The present disclosure also relates to the use of such A? peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

Abstract: An automatic descent control device includes a line configured to be attached to a load. A line system retracts slack from the line when the line is not loaded and extends the line when the line is loaded. At least one braking system provides a braking force when the line is loaded so as to control extension of the line and a descent rate of the load. The at least one braking system is operable in at least two configurations, a first configuration that the at least one braking system lowers the load at a first descent rate, and a second configuration that the at least one braking system lowers or locks the load at a second descent rate. The load being a constant and the first descent rate is greater than the second descent rate.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid ? (A?) peptides (in the following referred to as A?), comprising the amino acid sequence EX2X3YX5X6NLX9A X11QLCAX16IX18X19X20 ED (SEQ ID NO:632). The present disclosure also relates to the use of such A? peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

Abstract: A preparation vessel, in particular for a food processor, has a vessel wall and a preparation area surrounded by the vessel wall. The vessel wall has a cooling device that contacts the vessel wall in a heat-conducting manner for cooling a preparation item present in the preparation area. The vessel wall in at least a partial area has a double-walled design, with an inner wall bordering the preparation area and an outer wall that is formed separately from the inner wall and spaced apart from the inner wall by a gap, wherein the gap has the cooling device and a phase change material located between the cooling device and the outer wall as viewed in a direction from the preparation area to the outer wall.

Abstract: The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D, and ii) an amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for amyloid ? (A?) peptides (in the following referred to as A?), comprising the amino acid sequence EX2X3YX5X6NLX9AX11QLCAX16IX18X19X20 ED. The present disclosure also relates to the use of such A? peptide binding polypeptides as therapeutic, prognostic and/or diagnostic agents.

Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy. The disclosure provides an HER3 binding polypeptide comprising a HER3 binding motif, which motif consists of the amino acid sequence EKYX4AYX7EIW X11LPNLTX17X18QX20 AAFIGX26 LX28D (SEQ ID NO:110).

Abstract: A method for directly converting wind energy into electrical energy is provided. An air stream is ionized and then routed through the electrical field of a collection electrode providing an opposing field for the air ions. The ions are collected on a collection electrode. The electrical potential of the collection electrode is higher than the ionizer, and discharged. A counter-electrode in front of the collection electrode has an electrical potential higher than the collection electrode. Ionized air molecules overcome the electrical field emanating from the counter-electrode via wind power. An apparatus for carrying out the method is provided. An optional retaining electrode, located in front of the ionizer electrode, drives ionized air in the counter-electrode and collection electrode direction. The apparatus is expediently located in a flow channel, with inlet and outlet electrodes at respective ends. A plurality of flow channels combine to form a flow generation module.

Abstract: The invention relates to a device (1, 10) for the production of cooled coffee, comprising a brewing unit (4) for the production of coffee, a cooling assembly (11) and a coffee cooler (14) formed as a heat exchanger, wherein the coffee cooler (14) has at least one first and one second flow path that are connected thermally but not in a fluid-conducting manner, wherein a coolant can flow through the first flow path and the second flow path is connected in a fluid-conducting manner with a coffee outlet (5) of the brewing unit (4).

Abstract: The present disclosure relates to polypeptides which bind to human epidermal growth factor receptor 3 (HER3) and to use of such polypeptides in imaging and therapy.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.

Abstract: A device for the propulsion and eccentric braking of a vehicle having a pedal drive, which includes a first shaft, a drive mechanism including one or a plurality of chain wheels, belt pulleys or elements of a Cardan drive, a second hollow shaft arranged concentrically about the first shaft mounted into a rear wheel, a freewheel clutch mounted between the first shaft and the drive mechanism, and an optionally engageable reverse gear mechanism mounted between the first and the second shaft. The first and the second shafts are connected to each other in a torsionally rigid manner when the reverse gear mechanism is in the engaged and disengaged state. The freewheel clutch prevents a rotation of the drive mechanism relative to the first shaft in a clockwise direction and is in a freewheeling state when the drive mechanism rotates in a counter-clockwise direction relative to the first shaft.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis, diagnostics, and imaging.

Abstract: A method for directly converting wind energy into electrical energy is provided. An air stream is ionized and then routed through the electrical field of a collection electrode providing an opposing field for the air ions. The ions are collected on a collection electrode. The electrical potential of the collection electrode is higher than the ionizer, and discharged. A counter-electrode in front of the collection electrode has an electrical potential higher than the collection electrode. Ionized air molecules overcome the electrical field emanating from the counter-electrode via wind power. An apparatus for carrying out the method is provided. An optional retaining electrode, located in front of the ionizer electrode, drives ionized air in the counter-electrode and collection electrode direction. The apparatus is expediently located in a flow channel, with inlet and outlet electrodes at respective ends. A plurality of flow channels combine to form a flow generation module.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.