Patents by Inventor Stefan Steinbacher

Stefan Steinbacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7076956
    Abstract: A combustion chamber suitable for a gas turbine engine is provided with at least one Helmholtz resonator having a resonator cavity and a damping tube in flow communication with the chamber interior. The damping tube is provided with at least one cooling hole extending through its wall for improved damping and cooling.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: July 18, 2006
    Assignees: Rolls-Royce PLC, Rolls-Royce Deutschland Ltd. & Co. KG
    Inventors: Kenneth James Young, Klaus Stefan Steinbach, Volker Herzog, Iain David Jeffrey Dupere, Alan Philip Geary, Miklos Gerendas
  • Publication number: 20040226502
    Abstract: This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 18, 2004
    Inventors: Adelbert Bacher, Stefan Hecht, Robert Huber, Johannes Kaiser, Felix Rohdich, Stefan Steinbacher
  • Patent number: 6262238
    Abstract: Process for the production of a functional immunoglobulin or functional derivative or fragment thereof with an improved stability in a eukaryotic or prokaryotic organism by transformation with an expression vector which contains a recombinant gene which codes for the said immunoglobulin derivative or fragment which is characterized in that a modified gene is used which contains at least one codon which is substituted compared to the unmodified gene and codes for a more frequent amino acid. In this way it is also possible to produce active antibodies free of disulfide bridges. In a modification of the process it is possible to selectively destabilize antibodies.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: July 17, 2001
    Assignee: Roche Diagnostic, GmbH
    Inventors: Boris Steipe, Stefan Steinbacher
  • Patent number: 5854027
    Abstract: A process for improving the stability of an antibody or fragment thereof is disclosed. A gene encoding for an amino acid sequence of a variable domain of an antibody or fragment thereof to be modified is provided, and the amino acid sequence of the gene is compared with one of consensus tables 1-6. At least one codon of each pair of codons in the gene, which pair together code for disulfide bridge-forming cysteines, are modified so that all disulfide bridges present in the antibody as produced in a eukaryotic cell are absent from the modified antibody as produced in the method. At least one additional codon in the gene which codes for an amino acid other than a disulfide bridge-forming cysteine is also modified. A prokaryotic microorganism is transformed with the modified gene and additional variable domain DNA, and the modified antibody or fragment thereof is expressed in the prokaryotic microorganism.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: December 29, 1998
    Assignee: Boehringer Mannheim GmbH
    Inventors: Boris Steipe, Stefan Steinbacher