Patents by Inventor Stefan Tasler

Stefan Tasler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
    Patent number: 11292788
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: April 5, 2022
    Assignee: Immunic AG
    Inventors: Jakob Felding, Hella Kohlhof, Manfred Groppel, Rolf Andreas Muhler, Daniel Vitt, Carine Chevrier, Mirko Zaja, Stefan Tasler
  • IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
    Publication number: 20210061796
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 4, 2021
    Applicant: Immunic AG
    Inventors: Jakob FELDING, Hella KOHLHOF, Manfred GROPPEL, Rolf Andreas MUHLER, Daniel VITT, Carine CHEVRIER, Mirko ZAJA, Stefan TASLER
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION
    Publication number: 20200377514
    Abstract: Disclosed are compounds within the scope of formula (II) or a salt or solvate thereof, medical uses involving them, and methods for their preparation
    Type: Application
    Filed: August 18, 2020
    Publication date: December 3, 2020
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN, Juergen KRAUS, Mirko ZAJA
  • KV1.3 inhibitors and their medical application
    Patent number: 10822345
    Abstract: Compounds of formula (II) or a pharmaceutically acceptable salt or solvate thereof, the medical uses thereof for diseases or medical conditions where the inhibition of the voltage-gated potassium channel Kv1.3 is beneficial, and methods for their preparation.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 3, 2020
    Assignee: 4SC AG
    Inventors: Stefan Tasler, Ilga Krimmelbein, Juergen Kraus, Mirko Zaja
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION
    Publication number: 20200339592
    Abstract: Compounds of formula (II) or a pharmaceutically acceptable salt or solvate thereof, the medical uses thereof for diseases or medical conditions where the inhibition of the voltage-gated potassium channel Kv1.3 is beneficial, and methods for their preparation.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN, Juergen KRAUS, Mirko ZAJA
  • Kv1.3 inhibitors and their medical application
    Patent number: 10723743
    Abstract: Compounds of formula (II) or a pharmaceutically acceptable salt or solvate thereof, the medical uses thereof for diseases or medical conditions where the inhibition of the voltage-gated potassium channel Kv1.3 is beneficial, and methods for their preparation.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: July 28, 2020
    Assignee: 4SC AG
    Inventors: Stefan Tasler, Ilga Krimmelbein, Juergen Kraus, Mirko Zaja
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATIONS
    Publication number: 20190352308
    Abstract: The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein A1, A2, A3, A4, A5, A6, Y, R2 and R7 are as defined herein, and methods for producing such compounds.
    Type: Application
    Filed: July 25, 2019
    Publication date: November 21, 2019
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN
  • Kv1.3 inhibitors and their medical applications
    Patent number: 10399991
    Abstract: The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein A1, A2, A3, A4, A5, A6, Y, R2 and R7 are as defined herein, and methods for producing such compounds.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: September 3, 2019
    Assignee: 4SC AG
    Inventors: Stefan Tasler, Ilga Krimmelbein
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION
    Publication number: 20190185483
    Abstract: Compounds of formula (II) or a pharmaceutically acceptable salt or solvate thereof, the medical uses thereof for diseases or medical conditions where the inhibition of the voltage-gated potassium channel Kv1.3 is beneficial, and methods for their preparation.
    Type: Application
    Filed: February 13, 2019
    Publication date: June 20, 2019
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN, Juergen KRAUS, Mirko ZAJA
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION
    Publication number: 20180051034
    Abstract: Disclosed are compounds within the scope of formula (II) or a salt or solvate thereof, medical uses involving them, and methods for their preparation
    Type: Application
    Filed: March 14, 2016
    Publication date: February 22, 2018
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN, Juergen KRAUS, Mirko ZAJA
  • KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATIONS
    Publication number: 20170369501
    Abstract: The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein A1, A2, A3, A4, A5, A6, Y, R2 and R7 are as defined herein, and methods for producing such compounds.
    Type: Application
    Filed: March 14, 2016
    Publication date: December 28, 2017
    Applicant: 4SC AG
    Inventors: Stefan TASLER, Ilga KRIMMELBEIN
  • IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation
    Patent number: 8592456
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: November 26, 2013
    Assignee: 4SC Discovery GmbH
    Inventors: Johann Leban, Stefan Tasler, Roland Baumgartner, Wael Saeb, Carine Chevrier
  • IL17 and IFN-gamma inhibition for the treatment of autoimmune inflammation
    Patent number: 8354436
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: January 15, 2013
    Assignee: 4SC Discovery GmbH
    Inventors: Johann Leban, Stefan Tasler, Wael Saeb, Carine Chevrier
  • IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION
    Publication number: 20120196862
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 2, 2012
    Applicant: 4SC Discovery GmbH
    Inventors: Johann LEBAN, Stefan TASLER, Wael SAEB, Carine CHEVRIER
  • IL17 AND IFN-GAMMA INHIBITION FOR THE TREATMENT OF AUTOIMMUNE INFLAMMATION
    Publication number: 20120196861
    Abstract: The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salt or solvate thereof, as anti-inflammatory and immunomodulatory agents.
    Type: Application
    Filed: January 27, 2012
    Publication date: August 2, 2012
    Applicant: 4SC Discovery GmbH
    Inventors: Johann LEBAN, Stefan TASLER, Roland BAUMGARTNER, Wael SAEB, Carine CHEVRIER
  • Aryloxypropanolamines, methods of preparation therof and use of aryloxypropanolamines as medicaments
    Patent number: 8207174
    Abstract: This invention relates to novel aryloxypropanolamines. The invention also relates to the pharmaceutically acceptable salts and solvates containing said compounds, methods for the preparation thereof and to respective synthetic intermediates. Said compounds have agonistic activity at ?3 adrenergic receptors and are useful for treatment of ailments influenced by activation of ?3 adrenergic receptors.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: June 26, 2012
    Assignee: 4SC AG
    Inventors: Stefan Tasler, Daniel Vitt, Kristina Wolf, Andrea Aschenbrenner, Peter Ney
  • Benzazole analogues and uses thereof
    Publication number: 20110172241
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents —Y are attached to the 5- or 6-position of the benzazole.
    Type: Application
    Filed: March 23, 2011
    Publication date: July 14, 2011
    Applicant: 4SC AG
    Inventors: Thomas HERZ, Rolf KRAUSS, Michael KUBBUTAT, Martin LANG, Christoph SCHAECHTELE, Stefan TASLER, Frank TOTZKE
  • BENZAZOLE ANALOGUES AND USES THEREOF
    Publication number: 20090270410
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents -Y are attached to the 5- or 6-position of the benzazole.
    Type: Application
    Filed: July 7, 2009
    Publication date: October 29, 2009
    Applicant: 4SC AG
    Inventors: Thomas HERZ, Rolf KRAUSS, Michael KUBBUTAT, Martin LANG, Christoph SCHAECHTELE, Stefan TASLER, Frank TOTZKE
  • Benzazole analogues and uses thereof
    Patent number: 7576090
    Abstract: The present invention relates to compounds of the general formulas (I), (Ia) and (II) and salts and physiologically functional derivatives thereof, wherein the substituents —Y are attached to the 5- or 6-position of the benzazole.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 18, 2009
    Assignee: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke
  • Benzazole analogues and uses thereof
    Patent number: 7514460
    Abstract: The present invention relates to N2-heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: April 7, 2009
    Assignee: 4SC AG
    Inventors: Thomas Herz, Rolf Krauss, Michael Kubbutat, Martin Lang, Christoph Schaechtele, Stefan Tasler, Frank Totzke