Abstract: An implant for planar connection of tissue to bone is proposed, wherein the implant including a clamping surface and at least three securing members connected to the clamping surface, and wherein the clamping surface comprises an outer edge and an inner edge, wherein the outer edge is connected at least partially to the inner edge at least partially by at least one connecting web, and/or the clamping surface comprises an outer edge and at least one opening arranged within the clamping surface, which opening is connected by at least one connecting web at least to a partial area of the outer edge of the clamping surface.

Abstract: The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-protein (AS160-protein) with a test substance, and identifying a test substance as a substance altering glucose uptake of a cell by detecting a signal indicative for altered glucose uptake of a cell; a test system comprising a gene coding for the AKT substrate 160 kDa-protein (AS160-protein) and an inducible promoter providing for controllable expression of the gene; the use of the test system for the identification of a substance improving glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell; and the use of AS 160-protein in a model for type 2 diabetes.

Abstract: The present invention relates to applications based on the findings of the interaction between NKp80 and its ligand AICL. A method of treating or preventing inflammatory diseases in a subject is disclosed, comprising administering a substance blocking the interaction between NKp80 and AICL, in particular for treating autoimmune diseases. Preferably, the substance is selected from the group comprising anti-NKp80-antibodies, anti-AICL-antibodies, soluble NKp80, soluble AICL, or functional fragments thereof.

Abstract: The invention describes a method for measuring a protein tyrosine phosphatase in biological material using 6,8-difluoro-4-methylumbelliferyl phosphate (“DiFMUP”).