Abstract: The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder.

Abstract: A system and method are disclosed for monitoring rides in a vehicle in which a driver of the vehicle picks up a rider at a pickup location and drives the rider to a drop-off destination. The system includes at least one sensor arranged in the vehicle and configured to capture sensor data during the rides, a transceiver configured to communicate with a personal electronic device of a driver of the vehicle, a non-volatile memory configured to store data; and a processor. The system captures sensor data during a ride, receives a ride identifier from the personal electronic device that uniquely identifies the ride, and stores the sensor data captured during the ride with the ride identifier as metadata.

Abstract: A method for producing a mammalian brain protein hydrolysate composition, by providing a mammalian brain protein hydrolysate, adding Zn ions to the mammalian brain protein hydrolysate to form a complex with the Zn ions and the mammalian brain protein hydrolysate, and obtaining the complex with the Zn ions and the mammalian brain protein hydrolysate in a mammalian brain protein hydrolysate composition. A composition with a mammalian brain protein hydrolysate. A nutritional supplement with a mammalian brain protein hydrolysate. A pharmaceutical composition with a mammalian brain protein hydrolysate.

Abstract: A medical device for treating an associated patient includes an electronic processing device configured to receive ventilation waveform data during mechanical ventilation of the associated patient and to perform a patient-ventilator asynchrony monitoring method including detecting initial patient-ventilator asynchrony events during a training period of the mechanical ventilation by analysis of measurements of the associated patient acquired during the training period; training a machine learning (ML) component to analyze ventilation waveform data to detect patient-ventilator asynchrony events using the ventilation waveform data received during the training period with labels indicating the initial patient-ventilator asynchrony events; applying the patient-specific ML component to the ventilation waveform data received after the training period to detect patient-ventilator asynchrony events occurring after the training period; and a display device configured to display an indication of patient-ventilator async

Abstract: A combustion chamber suitable in particular for use in an engine comprises a combustion space, a combustion space wall delimiting the combustion space, and a plurality of cooling channel webs extending from a surface of the combustion space wall which faces away from the combustion space and separating mutually adjacent cooling channels from one another. The cooling channel webs are each provided with a projection extending from an end face of the cooling channel webs which faces away from the combustion space. Furthermore, the combustion chamber comprises a plurality of cover elements, wherein each cover element extends along a longitudinal axis of a cooling channel delimited by two mutually adjacent cooling channel webs between the projections of the mutually adjacent cooling channel webs and is form-fittingly connected to the projections of the two mutually adjacent cooling channel webs in order to cover the cooling channel.

Abstract: A respiration monitoring device comprises an electronic controller configured to: receive an audio signal that is acoustically coupled with an airway of a patient receiving mechanical ventilation therapy from a mechanical ventilator; map the audio signal to one or more lung disease or injury condition categories; and at least one of: display the mapped one or more lung disease or injury condition categories on a display device; and determine a recommended adjustment to one or more parameters of the mechanical ventilation therapy delivered to the patient based at least on the mapped lung disease or injury condition categories and displaying the recommended adjustment on the display device.

Abstract: A mechanical ventilation device comprising at least one electronic controller is configured to receive images of lungs of a patient undergoing mechanical ventilation therapy with a mechanical ventilator, the images being acquired over time and having timestamps; process the images to generate timeline images at corresponding discrete time points; and display a timeline of the timeline images on a display device.

Abstract: A respiratory monitoring device includes an electronic controller configured to: analyze an audio signal triggered during inspiratory and expiratory phases of a patient receiving mechanical ventilation therapy from a mechanical ventilator, the audio signal being acoustically coupled into the airway of the patient, to determine resonant frequencies of the airway; determine a shift in the resonant frequencies between the inspiratory and expiratory phases to determine a presence of pendelluft inside of a lung of the patient; and output an indication of the presence of pendelluft.

Abstract: A sleep study system comprises a set of sensors for monitoring physiological parameters of a subject during sleep as part of a sleep study and for monitoring the sleep stage of the subject. It is determined if intervention to the subject is needed for maintenance or repair to the sleep study system. If so, a time to perform the intervention is also derived based on the sleep stage of the subject, in particular so as to be least disruptive to the subject.

Abstract: A combustion chamber suitable in particular for use in an engine comprises a combustion space, a combustion space wall delimiting the combustion space, and a plurality of cooling channel webs extending from a surface of the combustion space wall which faces away from the combustion space and separating mutually adjacent cooling channels from one another. The cooling channel webs are each provided with a projection extending from an end face of the cooling channel webs which faces away from the combustion space. Furthermore, the combustion chamber comprises a plurality of cover elements, wherein each cover element extends along a longitudinal axis of a cooling channel delimited by two mutually adjacent cooling channel webs between the projections of the mutually adjacent cooling channel webs and is form-fittingly connected to the projections of the two mutually adjacent cooling channel webs in order to cover the cooling channel.

Abstract: An apparatus for the thermal treatment of samples within sample containers comprises: a sample block a receiving region for the sample containers; a first temperature-control device thermally coupled to the sample block designed to set a temperature of the sample block; a cover plate arranged in the receiving region of the sample block; a second temperature-control device thermally coupled to the cover plate and designed to set a temperature of the cover plate; and a control unit connected to the first and the second temperature-control devices and designed to control the first and the second temperature-control device as to control the temperature of the sample block and the temperature of the cover plate such that the temperatures are coordinated with one another. A method for the thermal treatment of samples contained in sample containers is also disclosed.

Abstract: The present invention relates to a method for determining in a subject's biological sample the relative proportions of papillary renal cell carcinoma (pRCC), clear cell renal cell carcinoma (ccRCC), and chromophobe renal cell carcinoma (chRCC), an array comprising capture molecules capable of specifically binding to RCC signature genes or coding sequences thereof or products encoded thereby, and the use of RCC signature genes for classifying a subject into a renal cell carcinoma (RCC) risk group and/or for determining in a subject's biological sample the relative proportions of pRCC, ccRCC, and chRCC.

Abstract: The present invention relates to systems and methods for characterizing at least one anatomical parameter of an upper airway of a patient by analysing spectral properties of an utterance, comprising: a mechanical coupler comprising means for restricting the jaw position of the patient; means for recording an utterance; and processing means for determining at least one anatomical parameter of the upper airway from the recorded utterance and comparing the recorded utterance to a threshold value. In addition the present invention relates to the use of the above mentioned systems as a diagnostics tool for assessing obstructive sleep apnea.

Abstract: An arrangement and method for polymerase chain reaction with multi-channel fluorescence measurement includes two heating elements, each including a sample receptacle for receiving a sample carrier, wherein the sample receptacles each have a plurality of cavities; two measuring heads, each movable relative to the heating elements, wherein each measuring head is configured such that excitation light is coupled into each of the cavities and fluorescence light can be coupled out from the cavities; a fluorescence unit including: a rotatable carrier; at least one optical module disposed on the carrier and configured to generate the excitation light having at least one wavelength; and a detection unit for detecting a fluorescence in the cavities; and a coupling module configured for guiding the excitation light from the fluorescence unit to the measuring heads and for guiding the fluorescence light from the measuring heads to the fluorescence unit.

Abstract: The present invention relates to a method for re-synchronizing a breathing pattern of a patient (16) suffering from ataxic breathing, the method including the steps of monitoring the breathing pattern of the patient (16) during sleep; detecting whether the monitored breathing pattern includes an ataxic breathing episode; and if an ataxic breathing episode is detected, ventilating the patient (16) and eliminating a spontaneous breathing of the patient (16) for a predetermined first period of time (?t1) by providing a flow of breathing gas (14) to an airway of the patient (16) with a volume of the breathing gas (14) provided per minute being above an individual-related threshold value of the patient (16).

Abstract: Disclosed is cerebrolysin for use in reducing mortality in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) patients.

Abstract: Telehealth was introduced as a promising service to support integrated care in management of chronic obstructive pulmonary disease (COPD). Implementation of telehealth is geared towards improving self-management and providing remote support for continuous disease management. However, it is currently not clear where telehealth services fit into existing pathways for COPD disease management. This exploratory study aims to identify the practices of clinical stakeholders along a Greek clinical care pathway for COPD, detail the challenges of those practices, and to identify where telehealth solutions may be implemented to reduce clinical resource utilization.

Abstract: The present disclosure relates to an air supply arrangement for a vehicle, the air supply arrangement comprising an air supply duct, an ionising member located in the air supply duct and a passive collecting member located in the air supply duct downstream of the ionising member, wherein a shortest path length of an air flow between the ionising member and the collecting member is in the range of from 20 to 70 centimeters (cm), preferably in the range of from 25 to 50 cm. The disclosure further relates to an external portion of such an air supply arrangement and a vehicle with such an air supply arrangement.

Abstract: A mandibular advancement device (102,302) includes a first brace member (104,304) structured to engage an upper dentition of a user, a second brace member (106,306) structured to engage a lower dentition of a user, and a number of coupling assemblies (108,308) each coupling the first brace member to the second brace member. Each of the number of coupling assemblies includes an actuating element (114,314) structured to automatically adjust a dimension (136,336) of the coupling assembly. The actuating element is selected from the group consisting of a biasing element (114) and a volume responsive material (314).

Abstract: A method for determining a personalized anti-snoring solution for a patient includes performing an analysis of a sleep period of the patient in which snoring by the patient is occurring; advising the patient of an anti-snoring solution based on information obtained in the analysis; tracking a further sleep period of the patient in which the patient is employing the anti-snoring solution; and advising the patient of changes to the anti-snoring solution based on a comparison of information obtained in the tracking with data obtained in the analysis.