Patents by Inventor Stefan ZAHLER

Stefan ZAHLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions
    Patent number: 9957273
    Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: May 1, 2018
    Assignee: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor Havlicek, Antonin Sturc, Vladimir Krystof, Radek Jorda, Tomas Pospisil, Stefan Zahler, Angelika Vollmar, Miroslav Strnad
  • 5-SUBSTITUTED 7-[4-(2-PYRIDYL)PHENYLMETHYLAMINO]-3-ISOPROPYLPYRAZOLO4,3-D]PYRIMIDINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS
    Publication number: 20180072736
    Abstract: 5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.
    Type: Application
    Filed: October 2, 2015
    Publication date: March 15, 2018
    Applicant: USTAV EXPERIMENTALNI BOTANIKY AV CR, V.V.I.
    Inventors: Libor HAVLICEK, Antonin STURC, Vladimir KRYSTOF, Radek JORDA, Tomas POSPISIL, Stefan ZAHLER, Angelika VOLLMAR, Miroslav STRNAD