Patents by Inventor Stefan Zielonka

Stefan Zielonka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NKP30 BINDERS
    Publication number: 20230287082
    Abstract: B7-H6-based compounds disclosed herein have favorable characteristics. Pharmaceutical compositions containing such a compound, the use of such compounds, and treatment with such pharmaceutical compositions are also disclosed. Methods for preparing a compound with an increased affinity for NKp30 are provided.
    Type: Application
    Filed: August 31, 2021
    Publication date: September 14, 2023
    Applicant: Merck Patent GmbH
    Inventors: Stefan Zielonka, Lars Toleikis, Simon Krah, Lukas Pekar
  • Fusion protein comprising an FGF-18 moiety
    Patent number: 11572395
    Abstract: The present invention relates to new fusion proteins comprising an FGF-18 moiety fused to an anti-NGF moiety. Said fusion protein can be used for the treatment of a cartilage disorder such as osteoarthritis or cartilage injury.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: February 7, 2023
    Inventors: Anne Gigout, Christian Brenneis, Thomas Rysiok, Stefan Zielonka
  • Methods for generating bispecific shark variable antibody domains and use thereof
    Patent number: 11001640
    Abstract: The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: May 11, 2021
    Assignee: Merck Patent GmbH
    Inventors: Stefan Becker, Bjoern Hock, Stefan Zielonka, Harald Kolmar, Martin Empting
  • FUSION PROTEIN COMPRISING AN FGF-18 MOIETY
    Publication number: 20200299347
    Abstract: The present invention relates to new fusion proteins comprising an FGF-18 moiety fused to an anti-NGF moiety. Said fusion protein can be used for the treatment of a cartilage disorder such as osteoarthritis or cartilage injury.
    Type: Application
    Filed: September 20, 2018
    Publication date: September 24, 2020
    Inventors: ANNE GIGOUT, CHRISTIAN BRENNEIS, THOMAS RYSIOK, STEFAN ZIELONKA
  • METHODS FOR GENERATING BISPECIFIC SHARK VARIABLE ANTIBODY DOMAINS AND USE THEREOF
    Publication number: 20180171020
    Abstract: The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.
    Type: Application
    Filed: October 21, 2015
    Publication date: June 21, 2018
    Applicant: Merck Patent GmbH
    Inventors: Stefan Becker, Bjoern Hock, Stefan Zielonka, Harald Kolmar, Martin Empting