Abstract: In an embodiment an ionization detector includes a gate-insulator-substrate electron-emission structure (GIS-EE) configured to emit low-energy electrons, a sample chamber configured for at least one gas to be detected, the sample chamber being adjacent to the GIS-EE and a measuring unit configured to detect and/or select charged particles, wherein the charged particles are due to the emitted electrons and/or comprise the emitted electrons.

Abstract: A system includes a container and a security label. The container is divisible into a plurality of parts and has a container body and a removable container closure. The security label has a first label section and a second label section forming respective parts of a common material web and a severing element which is arranged between the first and second label section with respect to a longitudinal axis of the security label. The security label is applied to the container such that the first label section is attached to the container body and the second label section surrounds the container closure. The second label section is formed such that the security label is closed along an edge line above the container closure by gluing and/or welding such that the second label section encloses the removable container closure.

Abstract: A method for aligning a workpiece in a working space of a machine tool having a numerical control system uses a probe. 3D models of the working space, probe, and workpiece are virtually displayed. The workpiece is positioned in the working space and the virtual workpiece is positioned in the virtual working space so that there is an initial coincidence between positions thereof. The probe is manually positioned relative to the workpiece, wherein a planned probing point and probing direction are selected based on a minimum distance of the virtual probe from the virtual workpiece, and are displayed. Enabling of the probing is based on quality of the planned probing point, and, when enabled, a probing operation is triggered, and coordinates of a probing point are determined. The position of the workpiece is recalculated using these coordinates, and the position of the virtual workpiece is updated.

Abstract: Presented herein are systems and methods for analyzing images of target particles that are bound to a surface of a substrate. In certain embodiments, systems and method described herein utilize techniques that remove background noise from interferometric images of small particles, allowing for increased accuracy in detection and/or characterization of individual particles. Such techniques, as described herein, may allow individual particles having sizes below about 100 nm (e.g., below about 50 nm; e.g., down to 20 nm) to be accurately detected within images, and, among other things, their characteristic sizes measured utilizing, e.g., their contrast.

Abstract: Example methods and systems relate to the modeling of production processes to include intermediate products. An enterprise resource planning (ERP) system receives user input to define an intermediate product, and generates a master data record for the intermediate product. The ERP system further receives user input to include the intermediate product in a production model within the ERP system. The production model is associated with a real-world production process. The production model is updated based on the master data record to integrate the intermediate product into a sequence of activities. The sequence of activities comprises a first activity that produces the intermediate product and a second activity that consumes the intermediate product. The ERP system executes a production order based on the production model. Execution of the production order includes tracking state information of the intermediate product within the ERP system.

Abstract: The invention relates to a method for processing a liquid sample situated in a receptacle, wherein an attachment device is attached to the receptacle such that at least one fluid line protrudes into the liquid sample and a fluid is directly dispensed into the liquid sample through the fluid line and/or a portion of the liquid sample is aspirated into the fluid line.

Abstract: In an embodiment an ionization detector includes a gate-insulator-substrate electron-emission structure (GIS-EE) configured to emit low-energy electrons, a sample chamber configured for at least one gas to be detected, the sample chamber being adjacent to the GIS-EE and a measuring unit configured to detect and/or select charged particles, wherein the charged particles are due to the emitted electrons and/or comprise the emitted electrons.

Abstract: The invention relates to an ion mobility spectrometer (1) having an ionization chamber (13), with at least one ionization source (3) and at least one drift chamber (14) arranged downstream of the ionization chamber (13) in a desired drift direction (D) of the ions, wherein the ionization chamber (13) is connected to a feed duct (4) through which a sample gas to be analysed can be fed into the ionization chamber (13), characterized in that the ion mobility spectrometer (1) has a discharge duct (5) separate from the feed duct (4), which discharge duct is connected to the ionization chamber (13) and through which the sample gas can be discharged from the ionization chamber (13), wherein a) the ion mobility spectrometer (1) is configured to operate the ionization chamber (13) substantially field-free, at least during an ionization phase, and, in an injection phase, to move ions by means of an electric field out of the ionization chamber (13) into the drift chamber (14) and/or b) the ionization source (3) is desig

Abstract: The invention relates to an electrical circuit in the form of a transimpedance amplifier stage, and to a method for operating this circuit. The invention furthermore relates to a circuit containing at least one signal amplifier that has at least one output connection, at least one input connection or at least one pair of differential input connections and at least two voltage supply connections, one of which may also be an earth or ground connection, wherein the signal amplifier has at least one additional connection that is connected internally to at least one of the input connections or the input connection via at least one further component, for example a diode.

Abstract: The invention relates to an ion transport device which is designed to transport ions by means of an electric field. The ion transport device has an ion transport channel in which an ion transport chamber is formed. In order to generate the electric field, the ion transport device has a plurality of field generating electrodes which are arranged one behind the other along the length of the ion transport channel in order to move ions through the ion transport chamber in a transport direction. The invention additionally relates to an ion mobility spectrometer and to a mass spectrometer.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein: —the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein:—the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein: —the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein: —the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an analysis device for analyzing substances using ion-mobility spectrometry.

Abstract: The invention relates to a method for operating an ion gate having a first, a second, and a third electrode which are arranged one after the other in an intended drifting direction of ions to be influenced by the ion gate, in such a way that the second electrode is arranged after the first electrode and the third electrode is arranged after the second electrode in the drift direction. The ion gate can be switched between a closed state, in which ions cannot drift through the ion gate in the intended drifting direction, and an open state, in which ions can drift through the ion gate in the intended drifting direction. This is accomplished by applying potentials that alternate over time to one or more of the electrodes. In a switching cycle of the ion gate, which comprises the open state and the closed state of the ion gate, two different closed states of the ion gate are produced. In a first closed state, the ion gate is closed by applying a first potential between the second and third electrodes.

Abstract: The invention relates to a device for processing a liquid sample, comprising a carrier that has at least one well for receiving the liquid sample, a processing unit for carrying out at least one processing step, and an actuating apparatus, which has an electrical control or regulating unit for controlling or regulating the processing step carried out by means of the processing unit, wherein the actuating apparatus, in particular the control or regulating unit, is mounted on the processing unit. The device is characterized in that the processing unit is mounted on the carrier.

Abstract: The invention relates to a method for processing a liquid sample situated in a receptacle, wherein an attachment device is attached to the receptacle such that at least one fluid line protrudes into the liquid sample and a fluid is directly dispensed into the liquid sample through the fluid line and/or a portion of the liquid sample is aspirated into the fluid line.

Abstract: The invention relates to a method for operating an ion gate having a first, a second, and a third electrode which are arranged one after the other in an intended drifting direction of ions to be influenced by the ion gate, in such a way that the second electrode is arranged after the first electrode and the third electrode is arranged after the second electrode in the drift direction. The ion gate can be switched between a closed state, in which ions cannot drift through the ion gate in the intended drifting direction, and an open state, in which ions can drift through the ion gate in the intended drifting direction. This is accomplished by applying potentials that alternate over time to one or more of the electrodes. In a switching cycle of the ion gate, which comprises the open state and the closed state of the ion gate, two different closed states of the ion gate are produced. In a first closed state, the ion gate is closed by applying a first potential between the second and third electrodes.

Abstract: A method and a system control a drug dosing device (1) for administering a drug to a patient (19). The quantity (c0) of the drug administered from the drug dosing device (1) is determined or calculated. The concentration of the drug in the gas exhaled by the patient (19) is measured as a first patient value (c1M). A simulation calculation is carried out, in which a second patient value (cp) is calculated from the administered quantity of the drug (I), taking into account a parameter (k10). A simulated first patient value (c1?) is calculated in the simulation calculation, taking into account the parameter (k10). A comparison of the simulated first patient value (c1?) to the measured first patient value (c1M) is carried out. The parameter (k10) is adapted on the basis of the comparison. The calculated second patient value (cp) is used to generate a control signal (S).