Patents by Inventor Stefania Fasano

Stefania Fasano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosensors in human gut organoids
    Patent number: 11926849
    Abstract: Ex vivo monolayer models of human interstinal epithelia that express sensors, and methods of use thereof for evaluation of the effects of test compounds on the human gut.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: March 12, 2024
    Assignees: The General Hospital Corporation, Massachusetts Institute Of Technology
    Inventors: Alessio Fasano, Timothy K. Lu, Stefania Senger, Maria Eugenia Inda
  • NEUROPROTECTIVE PEPTIDE
    Publication number: 20230127694
    Abstract: Inhibitors of MAPK3 (ERK1 MAP kinase), in particular to polypeptides having the ability to stimulate the global ERK signalling pathway in the brain and their use as neuroprotective and/or cognitive enhancing agents, are disclosed. Related polynucleotides, vectors, host cells and pharmaceutical compositions able to inhibit MAPK3, causing the stimulation of the global ERK signalling pathway, are also disclosed. Additionally, use of the afore inhibitors or stimulators in the treatment of neurodegenerative or neuropsychiatric disorders and cognitive impairment is also disclosed.
    Type: Application
    Filed: September 13, 2022
    Publication date: April 27, 2023
    Inventors: Riccardo Brambilla, Stefania Fasano, Marzia Indrigo, Alessandro Papale
  • Neuroprotective peptide
    Patent number: 11471502
    Abstract: Inhibitors of MAPK3 (ERK1 MAP kinase), in particular polypeptides having the ability to stimulate the global ERK signalling pathway in the brain and their use as neuroprotective and/or cognitive enhancing agents, are disclosed. Related polynucleotides, vectors, host cells and pharmaceutical compositions able to inhibit MAPK3, causing the stimulation of the global ERK signalling pathway, are also disclosed. Additionally, use of the afore inhibitors or stimulators in the treatment of neurodegenerative or neuropsychiatric disorders and cognitive impairment is also disclosed.
    Type: Grant
    Filed: November 23, 2018
    Date of Patent: October 18, 2022
    Assignee: University College Cardiff Consultants Ltd
    Inventors: Riccardo Brambilla, Stefania Fasano, Marzia Indrigo, Alessandro Papale
  • NEUROPROTECTIVE PEPTIDE
    Publication number: 20200360460
    Abstract: The invention relates to inhibitors of MAPK3 (ERK1 MAP kinase), in particular to polypeptides having the ability to stimulate the global ERK signalling pathway in the brain and their use as neuroprotective and/or cognitive enhancing agents. The invention also concerns related polynucleotides, vectors, host cells and pharmaceutical compositions able to inhibit MAPK3, causing the stimulation of the global ERK signalling pathway. Additionally, use of the afore inhibitors or stimulators in the treatment of neurodegenerative or neuropsychiatric disorders and cognitive impairment is also disclosed.
    Type: Application
    Filed: November 23, 2018
    Publication date: November 19, 2020
    Inventors: Riccardo Brambilla, Stefania Fasano, Marzia Indrigo, Alessandro Papale