Publication number: 20040180902
Abstract: A compound forula (I) below or a pharmaceuticaly acceptable salt or solvate thereof: wherein R1 is H or alkyl; R2 is aryl or cycloalkyl or heteroaryl; R3 is H or alkyl, wherein the alkyl group may be optionally substituted by one or more fluorine atoms; R4 is H, hydroxyalkyl, dihydroxyalkyl or hydroxyalkoxyalkyl; R5 is branched or linear alkyl, cycloalkyl, cycloalkylalkyl, aryl, or a single or fused ring aromatic heterocyclic group; R6 represents H or up to three substituents independently selected from the list consisting of: alkyl, alkenyl, aryl, alkoxy, hydroxy, halo, nitro, cyano, carboxy, carboxamido, sulphonamido, trifluoromethyl, or amino or mono- or di-alkylamino; R7 is H or halo; R8=is H or ═O; and any of R2 and R5 may optionally be substituted one or more times by halo, hydroxy, amino, cyano, nitro, carboxy, oxo, alkyl, alkenyl, aryl, alkoxy, carboxamido, sulphonamido, trifluoromethyl, or mono- or di-alkylamino; with the proviso that said compound of formula (I) is not a compound selecte
Type:
Application
Filed:
April 26, 2004
Publication date:
September 16, 2004
Inventors:
Carlo Farina, Stefania Gagliardi, Giuseppe Giardina, Marisa Martinelli
Patent number: 6506758
Abstract: A compound of formula (I):
or a salt thereof, or a solvate thereof, wherein:
A represents an optionally substituted aryl group or an optionally substituted heterocyclyl group;
Ra represents —CO—NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heterocyclyl or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclyl group;
R1 and R2 each independently represents hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R1 and R2 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and
R3 represents hydrogen, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carbox
Type:
Grant
Filed:
October 11, 2001
Date of Patent:
January 14, 2003
Assignees:
SmithKline Beecham Laboratoires Pharmceutiques, SmithKline Beecham SpA
Inventors:
Stefania Gagliardi, Guy Marguerite Marie Gerard Nadler, Pietro A T Novella