Patents by Inventor Stefanie Leue

Stefanie Leue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6500953
    Abstract: The invention concerns the preparation of nothapodytine or camptothecin derivatives which consists in causing 4-ethyl 2methyl hepta-2,4-dienoic acid act on a 3-aminomethyl 2-bromo quinoline derivative (III) wherein R1 and R2 are H or R1 is a halogen atom or alkyl, R2 is a O—CO—X radical as defined for the camptothecin derivatives; or R1 and R2 are defined for the known camptothecin derivatives or represent protected radicals or radicals easily convertible into the radicals R1 and R2, to obtain the quinoline derivative (IV); adding to the resulting quinoline derivative (2-methoxy carbonyl vinyl) tributyltin in the presence of a complex of palladium and triphenylarsin to obtain the quinoline derivative (V); cyclizing the resulting quinoline derivative to obtain the tetracyclic derivative (VI); then in subjecting said derivative to an ozonolysis followed by treatment with dimethyl sulphide to obtain the tetracyclic derivative (VII); saponification followed by decarboxylation in oxidising conditions o
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 31, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Khalid Mekouar, Yves Genisson, Stefanie Leue, Andrew-Elliot Greene
  • Patent number: 6486320
    Abstract: The present invention relates to a novel process for preparation of camptothecin and of its derivatives by convergent synthesis starting from a 3-(aminomethyl)quinoline derivative and 5-hydroxy-5-ethyl-6-oxo-5,6-dihydropyrancarboxylic acid and to the intermediates obtained.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: November 26, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Stefanie Leue, Stéphanie Garçon, Andrew-Elliot Greene, Yves Génisson, Patrick Léon
  • Publication number: 20020045756
    Abstract: The present invention relates to a novel process for preparation of camptothecin and of its derivatives by convergent synthesis starting from a 3-(aminomethyl)quinoline derivative and 5-hydroxy-5-ethyl-6-oxo-5,6-dihydropyrancarboxylic acid and to the intermediates obtained.
    Type: Application
    Filed: September 14, 2001
    Publication date: April 18, 2002
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Stefanie Leue, Stephanie Garcon, Andrew-Elliot Greene, Yves Genisson, Patrick Leon