Abstract: A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: a neutron source comprising a metallic target (1), and a Beryllium first reflector-moderator (4) peripheral to the neutron source and comprising a neutron activation area (10) configured to accommodate the neutron source and the material to be activated, the neutron activation area (10) of the first reflector-moderator (4) comprising a bore configured to accommodate the neutron source. FIG.

Abstract: A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: a neutron source comprising a metallic target (1), and a Beryllium first reflector-moderator (4) peripheral to the neutron source and comprising a neutron activation-area (10) configured to accommodate the neutron source and the material to be activated, the neutron activation area (10) of the first reflector-moderator (4) comprising a bore configured to accommodate the neutron source.

Abstract: The present invention relates to methods of treating cancers that over-express somatostatin receptors. More specifically, the invention provides a combined therapy in which a combination of Peptide Receptor Radionuclide Therapy (PRRT) and Immuno Oncology therapy (I-O therapy) are administered for the treatment of neuroendocrine tumors.

Abstract: The present invention relates to methods of treating cancers that overexpress somatostatin receptors, e.g. neuroendocrine tumors (NET). In particular, the invention provides novel therapies based on the combination of a peptide receptor radionuclide therapeutic (PRRT) agent and immuno-oncology (I-O) therapeutic agents, wherein said I-O therapeutic agents are selected from the group consisting of LAG-3 inhibitors, TIM-3 inhibitors, GITR angonists, TGF-? inhibitors, IL15/IL-15RA complex, and selected PD-1 inhibitors.

Abstract: A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: a neutron source comprising a metallic target (1), and a Beryllium first reflector-moderator (4) peripheral to the neutron source and comprising a neutron activation area (10) configured to accommodate the neutron source and the material to be activated, the neutron activation area (10) of the first reflector-moderator (4) comprising a bore configured to accommodate the neutron source.

Abstract: A neutron activator for neutron activation of a material, the neutron activator being configured to produce neutrons from an interaction with a proton beam (7), the neutron activator comprising: a neutron source comprising a metallic target (1), and a Beryllium first reflector-moderator (4) peripheral to the neutron source and comprising a neutron activation area (10) configured to accommodate the neutron source and the material to be activated, the neutron activation area (10) of the first reflector-moderator (4) comprising a bore configured to accommodate the neutron source.

Abstract: The present invention relates to methods of treating cancers that over-express somatostatin receptors. More specifically, the invention provides a combined therapy in which a combination of Peptide Receptor Radionuclide Therapy (PRRT) and Immuno Oncology therapy (I-O therapy) are administered for the treatment of neuroendocrine tumors.

Abstract: A method of detecting and/or analyzing a radioactive source emitting charged or neutral particles in a biological tissue, consisting essentially in using scintillating fibers having particular ratios of length or diameter to range of the particles emitted by the source; scanning the surface of the material with the detection rod; collecting by means of a SiPM, the scintillation light output generated by the particles having interacted with the scintillating fibers and emitted at the outlet end; optionally selecting signals corresponding to the particles entering the scintillating fibers in a substantially axial direction, that eliminates the particles from certain angles between the axis of the scintillating fiber and the direction of the particles entering the scintillating fiber, correlating the scintillation light output and the selected signals to the presence of a source of radiation located in the material to be analyzed; and optionally communicating these data to the user.

Abstract: The invention relates to detection of radiations by means of any appropriate devices, particularly those comprising small probes used e.g. in diagnostics or in surgery, or in biomedical or pharmacological research. The aim of the invention is to improve the performance of probes and their working methods in terms i.a of background, miniaturization sensitivity and selectivity.