Abstract: Methods for highly efficient and fast generation of transformed plants, highly efficient, mild and fast generation methods for introducing a biomolecule into an intact plant cell by a laser-assisted transfection method, and the regeneration of cell lines, whole tissues or organisms thereof.

Abstract: Methods for generating DNA free genome edited plants and the delivery of pre-assembled ribonucleoprotein complexes (RNP)—such as the Cas9/gRNA RNP complex—for highly efficient genome editing of cells, in particular of intact plant cells and tissues, selection of the transfected cells and regeneration of whole plants thereof.

Abstract: The technology provided herein pertains to methods for the modification of a target nucleic acid in vitro, ex vivo or in vivo in the genome of a cell by using a pre-assembled complex comprising a nucleic acid and a metal nanocluster and exposing the complex bound to a target nucleic acid to electromagnetic radiation.

Abstract: The technology provided herein pertains to methods for the modification of a target nucleic acid in vitro, ex vivo or in vivo in the genome of a cell by using a pre-assembled complex comprising a nucleic acid and a metal nanocluster and exposing the complex bound to a target nucleic acid to electromagnetic radiation.

Abstract: Method for producing an isoindole derivative, the isoindole derivative obtainable by the methods, a methods for stabilizing an isoindole derivative, and methods for detection and/or quantification of macromolecules.

Abstract: Resistive-sensors are provided wherein networks or nanoframeworks of conducting polymer nanowires are electrochemically grown from pre-polymer solutions in the junction gap located between electrode pairs.

Abstract: The present invention relates to a method for identifying compounds that affect a transport of a receptor of interest through a specific membrane trafficking pathway mediated by said receptor within the context of a generic membrane trafficking pathway, which generic pathway is not mediated by said receptor, characterised by the following steps: d) monitoring the transport of the receptor of interest in a cell in the presence of the compound, wherein the receptor is labelled with a first marker, e) monitoring the transport of a second marker through the generic membrane trafficking pathway in a cell in the presence of the compound, f) comparing the results obtained from steps a) and b) and thereby identifying a compound affecting the specific membrane trafficking pathway. Furthermore it relates to the generation of a compound database using the method according to the invention as well as to the compound database itself.