Patents by Inventor Stefano Gobbato

Stefano Gobbato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of the crystalline form III of tipiracil hydrochloride
    Patent number: 11344550
    Abstract: The present invention concerns a process for the preparation of the crystalline form III of Tipiracil hydrochloride having a content of residual solvents lower than the ICH limits. Said process is advantageous with respect to the known processes because it allows the production of the form III of Tipiracil hydrochloride suitable for use in the preparation of pharmaceutical finished products.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 31, 2022
    Assignee: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Lucia Cozzi, Jacopo Roletto, Paolo Paissoni
  • Process for the synthesis of 6-chloromethyluracil
    Patent number: 11028057
    Abstract: The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: June 8, 2021
    Assignee: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE SYNTHESIS OF 6-CHLOROMETHYLURACIL
    Publication number: 20200407330
    Abstract: The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
    Type: Application
    Filed: February 13, 2019
    Publication date: December 31, 2020
    Applicant: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Jacopo Roletto, Paolo Paissoni
  • PROCESS FOR THE PREPARATION OF THE CRYSTALLINE FORM III OF TIPIRACIL HYDROCHLORIDE
    Publication number: 20200330465
    Abstract: The present invention concerns a process for the preparation of the crystalline form III of Tipiracil hydrochloride having a content of residual solvents lower than the ICH limits. Said process is advantageous with respect to the known processes because it allows the production of the form III of Tipiracil hydrochloride suitable for use in the preparation of pharmaceutical finished products.
    Type: Application
    Filed: October 23, 2018
    Publication date: October 22, 2020
    Applicant: Procos S.P.A.
    Inventors: Fabio Morana, Stefano Gobbato, Lucia Cozzi, Jacopo Roletto, Paolo Paissoni
  • Process for the preparation of dimiracetam
    Patent number: 8476453
    Abstract: The invention relates to a method of manufacture of dimiracetam (2,5-dioxohexahydro-1 H-pyrrolo[1,2-a]imidazole), characterized in that a 4-oxo-butanoic acid ester is condensed with glycinamide in a one-pot reaction with a controlled pH. The reaction may be performed in aqueous solution or in an anhydrous lower alcohol solution.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: July 2, 2013
    Assignee: Neurotune AG
    Inventors: Carlo Farina, Jacopo Roletto, Stefano Gobbato
  • PROCESS FOR THE PREPARATION OF DIMIRACETAM
    Publication number: 20130123509
    Abstract: The invention relates to a method of manufacture of dimiracetam (2,5-dioxohexahydro-1 H-pyrrolo[1,2-a]imidazole), characterized in that a 4-oxo-butanoic acid ester is condensed with glycinamide in a one-pot reaction with a controlled pH. The reaction may be performed in aqueous solution or in an anhydrous lower alcohol solution.
    Type: Application
    Filed: July 25, 2011
    Publication date: May 16, 2013
    Applicant: NEUROTUNE AG
    Inventors: Carlo Farina, Jacopo Roletto, Stefano Gobbato