Patents by Inventor Stefano Maria Santini

Stefano Maria Santini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for generating highly active human dendritic cells from peripheral blood mononuclear cells
    Patent number: 7566568
    Abstract: The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: July 28, 2009
    Assignee: Istituto Superiore di Sanita
    Inventors: Filippo Belardelli, Stefano Maria Santini, Stefania Parlato, Tiziana Di Pucchio, Mariantonia Logozzi, Caterina Lapenta, Maria Ferrantini, Laura Santodonato, Giuseppina D'Agostino
  • Dendritic cells, uses therefor, and vaccines and methods comprising the same
    Publication number: 20090041792
    Abstract: Provided is a method of cross-priming CD8+ T cells to antigens using Dendritic Cells cultured in the presence of a type I Interferon and GM-CSF, and vaccines and methods of vaccination comprising said Dendritic Cells.
    Type: Application
    Filed: July 19, 2007
    Publication date: February 12, 2009
    Applicant: Istituto Superiore di Sanita
    Inventors: Filippo Belardelli, Maria Ferrantini, Caterina Lapenta, Laura Lattanzi, Stefania Parlato, Stefano Maria Santini
  • Method for generating highly active human dendritic cells from monocytes
    Publication number: 20040219168
    Abstract: The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them.
    Type: Application
    Filed: May 6, 2004
    Publication date: November 4, 2004
    Inventors: Filippo Belardelli, Stefano Maria Santini, Stefania Parlato, Tiziana Di Pucchio, Mariantonia Logozzi, Caterina Lapenta, Maria Ferrantini, Laura Santodanato, Giuseppina D'Agostino
  • Method for generating highly active human dendritic cells from monocytes
    Publication number: 20030092177
    Abstract: The present invention relates to a process for deriving dendritic cells from mononuclear cells in culture comprising the step of putting in contact type I IFN with said mononuclear cells. Dendritic cells suitable as cellular adjuvants in prophylactic as well as therapeutic vaccination of animal and human beings, are obtainable thereby, after a single step treatment in a brief period of time. Dendritic cells obtainable thereby, pharmaceutical compositions including them, in particular a vaccine comprising said cells as active principle, and a method of treatment of a pathology associated with the presence of an antigen in human beings, are further objects of the invention, as well as a kit for deriving said dendritic cells and a method for the ex vivo expansion of T cells using them.
    Type: Application
    Filed: April 27, 2001
    Publication date: May 15, 2003
    Inventors: Filippo Belardelli, Stefano Maria Santini, Stefania Parlato, Tiziana Di Pucchio, Mariantonia Logozzi, Caterina Lapenta, Maria Ferrantini, Laura Santodonato, Giuseppina D'Agostino