Patents by Inventor Stefano Sguassero

Stefano Sguassero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 10738000
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: August 11, 2020
    Assignee: Bracco Imaging SpA
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20190225570
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: February 14, 2019
    Publication date: July 25, 2019
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 10246400
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 2, 2019
    Assignee: Bracco Imaging S.P.A.
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20180222840
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: April 5, 2018
    Publication date: August 9, 2018
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof
    Patent number: 9963416
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: May 8, 2018
    Assignee: Bracco Imaging S.P.A.
    Inventors: Roberta Fretta, Pietro Delogu, Fernanda Di Giorgio, Alfonso Nardelli, Stefano Sguassero, Carlo Felice Viscardi
  • Continuous process for the preparation of (S)-2-acetyloxypropionic acid chloride
    Patent number: 9926257
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: March 27, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Silvia Ceragioli, Pietro Delogu, Armando Mortillaro, Alfonso Nardelli, Stefano Sguassero, Rosario Velardi, Carlo Felice Viscardi
  • METHOD FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID AND DERIVATIVES THEREOF
    Publication number: 20170210692
    Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
    Type: Application
    Filed: June 10, 2015
    Publication date: July 27, 2017
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Roberta FRETTA, Pietro DELOGU, Fernanda DI GIORGIO, Alfonso NARDELLI, Stefano SGUASSERO, Carlo Felice VISCARDI
  • CONTINUOUS PROCESS FOR THE PREPARATION OF (S)-2-ACETYLOXYPROPIONIC ACID CHLORIDE
    Publication number: 20150329464
    Abstract: The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 19, 2015
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Silvia CERAGIOLI, Pietro DELOGU, Armando MORTILLARO, Alfonso NARDELLI, Stefano SGUASSERO, Rosario VELARDI, Carlo Felice VISCARDI
  • Process for producing an omega-functionalized aliphatic carboxylic acid and intermediate products of said process, including 2-oxepanone-7-substituted products
    Patent number: 5917067
    Abstract: A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized .alpha.-olefins or acrylic esters. The process comprises an addition step, an oxidation step, an isomerization step, and one or more hydrogenation steps. The process allows to use raw materials that are available at low cost and to achieve high selectivity and high yield with industrially simple steps. The process includes the production of new intermediate products, including 2-oxepanone-7-substituted products.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: June 29, 1999
    Assignee: Industrie Chimiche Caffaro S.P.A.
    Inventors: Livius Cotarca, Paolo Maggioni, Alfonso Nardelli, Stefano Sguassero