Patents by Inventor Stefano Turchetta

Stefano Turchetta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12129224
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl[4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: October 29, 2024
    Assignee: ITALFARMACO SPA
    Inventors: Stefano Turchetta, Maurizio Zenoni, Elio Ullucci, Stefania Cocciolo, Giorgio Berardi, Nakia Maulucci
  • Publication number: 20230348368
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Application
    Filed: June 21, 2023
    Publication date: November 2, 2023
    Inventors: Stefano TURCHETTA, Maurio ZENONI, Elio ULLUCCI, Stefania COCCIOLO, Giorgio Berardi, Nakia MAULUCCI
  • Publication number: 20220177421
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 9, 2022
    Inventors: Stefano TURCHETTA, Maurizio ZENONI, Elio ULLUCCI, Stefania COCCIOLO, Giorgio BERARDI, Nakia MAULUCCI
  • Patent number: 9504640
    Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: November 29, 2016
    Assignee: Valeant Pharmaceuticals Luxembourg S.Á.R.L.
    Inventors: Werner Oberegger, Fang Zhou, Paul Maes, Stefano Turchetta, Graham Jackson, Pietro Massardo, Mohammad Ashty Saleh
  • Patent number: 9308174
    Abstract: New formulations of bendamustine hydrochloride having HPLC purity higher than 99% obtained through the lyophilization of aqueous solutions without organic solvents, are described.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: April 12, 2016
    Assignee: CHEMI S.P.A.
    Inventors: Stefano Turchetta, Maurizio Zenoni, Paolo Brandi
  • Patent number: 9272982
    Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: March 1, 2016
    Assignee: CHEMI S.P.A.
    Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
  • Patent number: 9266863
    Abstract: Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: February 23, 2016
    Assignee: CHEMI SPA
    Inventors: Lorenzo De Ferra, Maurizio Zenoni, Stefano Turchetta, Mauro Anibaldi, Ettore Ammirati, Paolo Brandi, Giorgio Berardi
  • Patent number: 9206229
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: December 8, 2015
    Assignee: CHEMI S.P.A.
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • Publication number: 20150232508
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Application
    Filed: August 1, 2013
    Publication date: August 20, 2015
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • Patent number: 9096491
    Abstract: A process for the preparation of a prodrug of 5-aminosalicylic acid, namely 2-butanoyloxy-5-amino-benzoic acid, and solid forms of such compound are described.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: August 4, 2015
    Assignee: CHEMI S.P.A.
    Inventors: Maurizio Zenoni, Umberto Ciambecchini, Lorenzo De Ferra, Stefano Turchetta, Vincenzo De Sio
  • Publication number: 20150202147
    Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
    Type: Application
    Filed: September 2, 2014
    Publication date: July 23, 2015
    Applicant: VALEANT INTERNATIONAL BERMUDA
    Inventors: Werner OBEREGGER, Fang ZHOU, Paul MAES, Stefano TURCHETTA, Graham JACKSON, Pietro MASSARDO, Mohammad Ashty SALEH
  • Patent number: 8981090
    Abstract: The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solvent characterized in that the mixture is subjected to the following steps: a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: March 17, 2015
    Assignee: Chemi S.p.A.
    Inventors: Umberto Ciambecchini, Stefano Turchetta, Maurizio Zenoni, Lorenzo De Ferra, Paolo Brandi
  • Patent number: 8946456
    Abstract: The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: February 3, 2015
    Assignee: Chemi S.p.A.
    Inventors: Umberto Ciambecchini, Stefano Turchetta, Lorenzo De Ferra, Maurizio Zenoni
  • Publication number: 20140378518
    Abstract: New formulations of bendamustine hydrochloride having HPLC purity higher than 99% obtained through the lyophilization of aqueous solutions without organic solvents, are described.
    Type: Application
    Filed: June 17, 2014
    Publication date: December 25, 2014
    Inventors: Stefano Turchetta, Maurizio Zenoni, Paolo Brandi
  • Publication number: 20140303396
    Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
  • Publication number: 20140170216
    Abstract: Polymorphous and amorphous forms of bupropion hydrobromide are described.
    Type: Application
    Filed: September 4, 2013
    Publication date: June 19, 2014
    Applicant: VALEANT INTERNATIONAL BERMUDA
    Inventors: Stefano Turchetta, Maurizio Zenoni
  • Publication number: 20140163251
    Abstract: A process for the preparation of a prodrug of 5-aminosalicylic acid, namely 2-butanoyloxy-5-amino-benzoic acid,and solid forms of such compound are described.
    Type: Application
    Filed: July 9, 2012
    Publication date: June 12, 2014
    Applicant: CHEMI S.P.A.
    Inventors: Maurizio Zenoni, Umberto Ciambecchini, Lorenzo De Ferra, Stefano Turchetta, Vincenzo De Sio
  • Patent number: 8604085
    Abstract: Polymorphous and amorphous forms of bupropion hydrobromide are described.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: December 10, 2013
    Assignee: Valeant International Bermuda
    Inventors: Stefano Turchetta, Maurizio Zenoni
  • Patent number: 8518988
    Abstract: Herein described is a novel crystalline form of the hydrochloride of the (4-hydroxycarbamoyl-phenyl)-carbamic acid (6-dimethylamino methyl-2-naphtalenyl) ester. In particular, herein described is a polymorph of the hydrochloride of the (4-hydroxycarbamoyl-phenyl)-carbamic acid (6-dimethylamino methyl-2-naphtalenyl) ester, characterized by a Powder X Ray Diffraction spectrum as indicated in FIG. 1, and/or by a DSC profile as indicated in FIG. 2, and/or by a TGA profile as indicated in FIG. 3 and/or by an IR spectrum as indicated in FIG. 4.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: August 27, 2013
    Assignee: Chemi SPA
    Inventors: Stefano Turchetta, Maurizio Zenoni
  • Patent number: 8445716
    Abstract: A process is described for preparing fesoterodine and/or fesoterodine fumarate comprising the esterification of (R)-feso deacyl with isobutyric acid or a precursor thereof, such as an isobutyryl halide or the isobutyric acid anhydride to give fesoterodine, in a mixture of water at alkaline pH and/or at least one organic solvent. This process allows obtaining products with high yields and purities, and in particular a product having a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-isobutyroyloxymethyl-phenyl isobutyrate less than 1% by mole and a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol less than 0.05% by mole.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: May 21, 2013
    Assignee: Chemi S.p.A.
    Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni